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您的检索式：作者名="Samuel M.Waititu"
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| 1 | Dose-response effects of in-feed antibiotics on growth performance and nutrient utilization in weaned pigs fed diets supplemented with yeast-based nucleotides显示文摘Dietary nucleotides are bioactive compounds with the potential to mitigate weaning-associated challenges in piglets. An experiment was conducted to determine the interaction effect of antimicrobial growth promoters(AGP) and a nucleotide-rich yeast extract(NRYE) on growth performance and apparent total tract digestibility(ATTD) of dry matter(DM), crude protein(CP) and gross energy(GE),and to establish whether NRYE supplementation may completely or partially replace AGP in diets for weaned pigs. In phase 1 and 2, corn, wheat, canola meal and soybean meal based diets, which were formulated to contain 0.0 or 0.1% NRYE with 0, 25, 50, 75 or 100% of the recommended AGP dosage, were fed to 108 twenty-one day old piglets(initial body weight 7.11 ± 0.9 kg; mean ±SD) from d 1 to 14 and15 to 28, respectively. Overall, increasing AGP level in NRYE supplemented diets linearly decreased average daily gain(ADG)(P = 0.002) and gain-to-feed ratio(G:F)(P = 0.007); and quadratically decreased ATTD of DM(P = 0.001), CP(P =0.003) and G:F(P = 0.017) during phase 2. Compared with control and pigs fed NRYE with 100% of recommended AGP dosage, pigs fed 0.1% NRYE without AGP had greater(P < 0.05) ADG and G:F in phase 2 and overall. In conclusion, supplementing 0.1% NRYE improved growth performance of pigs but this beneficial effect was reduced by increasing dietary AGP dosage. | Samuel M.Waititu Jung M.Heo Rob Patterson Charles M.Nyachoti | 2015 | Animal Nutrition2015，，3： | 2 |
| 2 | Short-term effect of supplemental yeast extract without or with feed enzymes on growth performance, immune status and gut structure of weaned pigs challenged with Escherichia coli lipopolysaccharide显示文摘Background: This study investigated the response of piglets receiving a yeast extract without or with a multi-enzyme mixture compared with an antimicrobial growth promoter(AGP) on performance, immune status and gut structure after an E. coli lipopolysaccharide(LPS) challenge. Thirty-six pigs were allotted to six treatments including: a non-challenged control(NCC); LPS-challenged control(CC); CC + AGP; CC + yeast extract; CC + enzymes; and CC + enzymes + yeast extract. On d 7, pigs were bled and thereafter injected with LPS or sterile saline. Blood samples were collected at 6, 48, and 96 h post-challenge. After 96 h post-challenge, pigs were euthanized to obtain duodenal, jejunal and ileal samples.Results: Overall(d 1 to 11), compared with CC pigs, AGP attenuated the LPS-induced reduction in ADG(P = 0.004),ADFI(P = 0.03) and gain/feed ratio(P = 0.01). At 6 h post-challenge, AGP pigs had lower plasma urea N(PUN; P = 0.02)and serum TNF-α concentration(P = 0.07), and higher platelet count(P = 0.04) and serum IL-10 concentration(P = 0.02) than CC pigs. At 48 h post-challenge, AGP pigs had lower PUN(P = 0.02) than CC pigs, whereas enzymes + yeast extract interacted non-additively(P = 0.001) to reduce PUN. At 96 h post-challenge, AGP pigs had lower PUN(P = 0.02)and higher duodenal(P = 0.03), jejunal(P = 0.01) and ileal(P = 0.07) villus height than CC pigs. In addition, enzymes +yeast extract interacted additively and non-additively to reduce ileal IFN-γ(P < 0.0001) and IL-10(P = 0.012) expression,respectively. Generally, no differences(P > 0.10) were observed between AGP and enzymes + yeast extract pigs on other measured parameters except for the downregulation of ileal IFN-γ(P < 0.0001) and TNF-α(P = 0.003) in enzymes + yeast extract pigs at 96 h post-challenge.Conclusions: The LPS challenged piglets receiving enzymes + yeast extract showed beneficial responses in gut structure and immunity commensurate with those receiving antibiotics, though the latter had better overall growth performance. | Samuel M.Waititu Fugui Yin Rob Patterson Juan C.Rodriguez-Lecompte Charles M.Nyachoti | 2017 | Journal of Animal Science and Biotechnology2017，8，2： | 1 |
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