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| 1 | The Arabidopsis DSO/ABCG 11 Transporter Affects Cutin Metabolism in Reproductive Organs and Suberin in Roots显示文摘除了它在对压力条件的保护的意义,表皮的盖子为在天线植物机关上形成的多样的表面结构的合适的开发是必要的。这层主要由一个角质矩阵组成,与表皮的蜡嵌入并且覆盖。在表皮的房间,角质和蜡跟随他们的生合成被建议被象 DSO/ABCG11 那样的 ABCG 类型 transporters 越过血浆膜出口到房间墙并且进一步到细胞外的矩阵。这里, DSO/ABCG11 功能的另外的方面被调查,主要在繁殖机关,它没在以前的报告被揭示。这被显示了相对微妙的词法、化学的显型的一根转基因的 DSO/ABCG11 silenced 线(dso-4 ) 的产生便于。这些包括的改变的花瓣和 silique 形态学,种子的熔化,和在在花和 siliques 的角质单体的层次的变化。dso-4 显型在胚胎外皮以及在发展中的种子的内乳纸巾对应于强壮的 DSO/ABCG11 基因表示。而且, DSO/ABCG11 蛋白质在胚胎 protoderm 显示了极的本地化。dso-4 异种叶子和茎的 Transcriptome 分析证明那项减少的 DSO/ABCG11 活动压制了很多联系表皮的基因的表示,暗示从血浆膜的表皮的类脂化合物的出口是在表皮新陈代谢的限制率的步。令人惊讶地, dso-4 的根软木脂作文被改变,以及二软木脂 biosynthetic 基因的根表示。一起拿,这研究在繁殖机关和根开发提供新卓见进角质和软木脂新陈代谢和他们的角色。 | David Panikashvili Jian Xin Shi Samuel Bocobza Rochus Benni Franke Lukas Schreiber Asaph Aharoni | 2010 | Molecular Plant2010，3，3： | 12 |
| 2 | Pharmacogenomics of EGFR-targeted therapies in non-small cell lung cancer:EGFR and beyond显示文摘Commonly observed aberrations in epidermal growth factor receptor(EGFR) signaling have led to the development of EGFR-targeted therapies for various cancers,including non-small cell lung cancer(NSCLC).EGFR mutations and overexpression have further been shown to modulate sensitivity to these EGFR-targeted therapies in NSCLC and several other types of cancers.However,it is clear that mutations and/or genetic variations in EGFR alone cannot explain all of the variability in the responses of patients with NSCLC to EGFR-targeted therapies.For instance,in addition to EGFR genotype,genetic variations in other members of the signaling pathway downstream of EGFR or variations in parallel receptor tyrosine kinase(RTK) pathways are now recognized to have a significant impact on the efficacy of certain EGFR-targeted therapies.In this review,we highlight the mutations and genetic variations in such genes downstream of EGFR and in parallel RTK pathways.Specifically,the directional effects of these pharmacogenetic factors are discussed with a focus on two commonly prescribed EGFR inhibitors:cetuximab and erlotinib.The results of this comprehensive review can be used to optimize the treatment of NSCLC with EGFR inhibitors.Furthermore,they may provide the rationale for the design of subsequent combination therapies that involve the inhibition of EGFR. | Christopher Delaney Samuel Frank R Stephanie Huang | 2015 | Chinese Journal of Cancer2015，34，4： | 6 |
| 3 | Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B显示文摘 | E. Jenny Heathcote Patrick Marcellin Maria Buti Edward Gane Robert A. De Man Zahary Krastev George Germanidis Samuel S. Lee Robert Flisiak Kelly Kaita Michael Manns Iskren Kotzev Konstantin Tchernev Peter Buggisch Frank Weilert Oya Ovunc Kurdas Mitchell L | 2011 | Gastroenterology2011，，1： | 5 |
| 4 | 胸腺肿瘤预后因素的现状显示文摘当患者被诊断某种疾病后,患者最想知道的信息就是该疾病的预后。预后受多种因素的影响,而对于肿瘤而言,最重要的因素是肿瘤累及的解剖范围,这就是肿瘤分期。分期系统不应与预后相混淆,肿瘤分期仅为预后的一部分内容。预后还会受治疗、患者个体因素(如合并症)、肿瘤特异相关因素和其他因素的影响,这些都参与构成预后因素。目前,ITMIG联合IASLC在UICC和AJCC的领导下,正在着手制定一个实用的正式的分期系统。制定解剖学分期系统的一个必然而重要的环节是评估预后因素。通过回顾文献寻找有用的预后因素是这一过程的第一步。 | 付浩 中国胸腺瘤协作组全体成员 Frank Detterbeck Samuel Youssef Enrico Ruffini Meinoshin Okumura | 2014 | 中国肺癌杂志2014，17，2： | 3 |
| 5 | Anti-inflammatory and analgesic activities of Melanthera scandens显示文摘Objective:To evaluate the anti-inflammatory and analgesic activities of leaf extract of Melanthera scandens(M.scandens).Methods:The crude leaf extract(39-111 mg/kg)of M.scandens was investigated for anti-inflammatory and analgesic activities using various experimental models.The anti-inflammatory activity was investigated using carragenin,egg-albumin induced oedema models,while acetic acid,formalin-induced paw licking and thermal-induced pain models were used to evaluate the antinociceptive property.Results:The extract caused a significant(P<0.05-0.001)dose-dependent reduction of inflammation and pains induced by different agents used.Conclusions:The leaf extract possesses anti-inflammatory and analgesic effects which may be mediated through the phytochemical constituents of the plant. | Jude E Okokon Anwanga E Udoh Samuel G Frank Louis U Amazu | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，2： | 2 |
| 6 | Eosinophilic esophagitis in children: Immunopathological analysis and response to fluticasone propionate显示文摘 | Jonathan E. Teitelbaum Victor L. Fox Frank J. Twarog Samuel Nurko Don Antonioli Gerald Gleich Kamran Badizadegan Glenn T. Furuta | 2002 | Gastroenterology2002，，： | 1 |
| 7 | Is blood cardioplegia superior to crystalloid cardioplegia显示文摘 | Samuel Jacob Antonios Kallikourdis Frank Sellke | 2008 | Interact CardioVasc Thorac Surg2008，7，： | 1 |
| 8 | Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B显示文摘 | E. Jenny Heathcote Patrick Marcellin Maria Buti Edward Gane Robert A. De Man Zahary Krastev George Germanidis Samuel S. Lee Robert Flisiak Kelly Kaita Michael Manns Iskren Kotzev Konstantin Tchernev Peter Buggisch Frank Weilert Oya Ovunc Kurdas Mitchell L | 2011 | Gastroenterology2011，，1： | 1 |
| 9 | Synthesis of Optically Active Calanolides A and B显示文摘 | Prashant P Deshpande Frank Tagliaferri Samuel F Victory Shija Yan David C Baker | 1995 | J Org Chem1995，60，11： | 1 |
| 10 | Method development for the speciation of chromium in river and industrial wastewater using GFAAS显示文摘 | SAMUEL M RITA C FRANK V | 2005 | Microchimica Acta2005，150，34： | 1 |
| 11 | Variability in measurement of abdominal aortic aneurysms显示文摘 | Frank A. Lederle Samuel E. Wilson Gary R. Johnson Donovan B. Reinke Fred N. Littooy Charles W. Acher Louis M. Messina David J. Ballard Howard J. Ansel for the Abdominal Aortic Aneurysm Detection Management Veterans Administration Cooperative Study Group* | 1995 | Journal of Vascular Surgery1995，，： | 1 |
| 12 | Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B显示文摘 | E. Jenny Heathcote Patrick Marcellin Maria Buti Edward Gane Robert A. De Man Zahary Krastev George Germanidis Samuel S. Lee Robert Flisiak Kelly Kaita Michael Manns Iskren Kotzev Konstantin Tchernev Peter Buggisch Frank Weilert Oya Ovunc Kurdas Mitchell L | 2011 | Gastroenterology2011，，1： | 1 |
| 13 | Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B显示文摘 | E. Jenny Heathcote Patrick Marcellin Maria Buti Edward Gane Robert A. De Man Zahary Krastev George Germanidis Samuel S. Lee Robert Flisiak Kelly Kaita Michael Manns Iskren Kotzev Konstantin Tchernev Peter Buggisch Frank Weilert Oya Ovunc Kurdas Mitchell L | 2011 | Gastroenterology2011，，1： | 1 |
| 14 | Improved silicone rubbers for the use as housing material in composite insulators 显示文摘 | Samuel A Frank S Konstantin O P | 2012 | IEEE Transactions on Dielectrics and Electrical Insulation2012，19，1： | 1 |
| 15 | 汞使用和污染的社会经济后果显示文摘过去,人类活动经常导致汞释放到生物圈中,而没有考虑其对人类和野生动物健康的负面后果。本文概述了人类和野生动物暴露于汞的途径。食用鱼类是甲基汞暴露的主要途径。人类也可以通过吸入较高浓度的气态元素汞而接收到毒性剂量的汞。我们提出任何降低汞暴露的有效途径都需要对汞的整个生命史进行研究。本文从全球观点研究了汞的生命史,然后比较了几个测定汞暴露降低的收益的方法、降低汞释放的政策选择、降低暴露的可能机制以及与汞风险评估以及不同人群交流的相关事宜。 | Edward B.Swain Paul M.Jakus Glenn Rice Frank Lupi Peter A.Maxson Jozef M.Pacyna Alan Penn Samuel J.Spiegel Marcello M.Veiga | 2007 | AMBIO-人类环境杂志2007，36，1： | 1 |
| 16 | Categorical induction as hypothesis assessment显示文摘 | MCDONALD J FRANK D M SAMUELS M | 2003 | The psychological record2003，53，： | 1 |
| 17 | Endovascular interventions training and credentialing for vascular surgeons显示文摘 | Rodney A. White Kim J. Hodgson Samuel S. Ahn Robert W. Hobson II Frank J. Veith | 1999 | Journal of Vascular Surgery1999，，： | 1 |
| 18 | Evidence for a critical role of gene occlusion in cell fate restriction显示文摘尽管有它的普遍存在,细胞命运的进步限制在系区别期间是糟糕理解的现象。我们最近使用了房间熔化试金定义我们称为的 epigenetic silencing 的一个模式 “ occlusion”,不管交易的 transcriptional 使活跃之物是否是在场的,在那里影响了基因,是由行动 cis 染色质机制的 silenced。我们假设了系不恰当的基因的那吸藏能贡献房间命运限制。这里,我们由介绍细菌的人工的染色体(用绳子拖的平底渡船) 测试这个假设,它缺乏为吸藏必要的染色质修正,进老鼠成纤维细胞。我们发现相应于堵塞内长的基因的用绳子拖的平底渡船 transgenes 在大多数情况中被表示,而相应于沉默却非堵塞的内长的基因的用绳子拖的平底渡船 transgenes 没被表示。这显示在 trans 的细胞的周围在成纤维细胞支持大多数堵塞基因的表示,并且这些基因的沉默状态是完全在 cis 的吸藏的后果。为相应于堵塞 myogenic 主人管理者 Myf5 的 BAC, BAC 上的 Myf5 transgene 的表示触发了成纤维细胞获得像肌肉的显型。这些结果在房间命运限制为基因吸藏的一个关键角色提供引人注目的证据。 | Jedidiah Gaetz Kayla L Clift Croydon J Femandes Frank Fuxiang Mao Jae Hyun Lee Li Zhang Samuel W Baker Timothy J Looney Kara M Foshay Wei-Hua Yu Andy Peng Xiang Bruce T Lahn | 2012 | Cell Research2012，22，5： | 1 |
| 19 | Abdominal aortic aneurysm in women显示文摘 | Frank A. Lederle Gary R. Johnson Samuel E. Wilson | 2001 | Journal of Vascular Surgery2001，，： | 1 |
| 20 | Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B显示文摘 | E. Jenny Heathcote Patrick Marcellin Maria Buti Edward Gane Robert A. De Man Zahary Krastev George Germanidis Samuel S. Lee Robert Flisiak Kelly Kaita Michael Manns Iskren Kotzev Konstantin Tchernev Peter Buggisch Frank Weilert Oya Ovunc Kurdas Mitchell L | 2011 | Gastroenterology2011，，1： | 1 |
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