|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 2 | Shear behavior of highstrength fiber reinforced concrete beams显示文摘 | SamirA Ashour Ghazi S | 1992 | ACI Structural Journal1992，89，2： | 1 |
| 3 | Lack of effect of antipsychotits on BNDF and NGF levels in hippocampus of Wistar rats显示文摘 | Samira S Valvassori Laura S | 2008 | Metab Brain Dis2008，23，： | 1 |
| 4 | Effects of lithium and valproate on oxidative stress and behavioral changes induced by administration of m-AMPH 显示文摘 | Dayane D da-Rosa Samira S Valvassori Amanda V Steckert | 2012 | Psychiatry Res2012，198，3： | 1 |
| 5 | Hemicellulose as a beater additive in papermaking显示文摘 | E1-Kalyoubi S F Samira F Heikal S O | 1983 | Cellulose Chem- istry and Technology1983，17，6： | 1 |
| 6 | Role of oxidative stress in the pathophysiology of bipolar disorder 显示文摘 | Amanda V Steckert Samira S Valvassori Morgana Moretti | 2010 | Neurochem Res2010，35，9： | 1 |
| 7 | Germination responses of Cymbopogon schoenanthus to salinity显示文摘 | Ayda K Mohamed N Samira S | 2011 | Acta Physiologiae Plan- tarum2011，33，： | 1 |
| 8 | Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in rats显示文摘 | Leda S B Garcia Clariss M Comim Samira S Valvassori | | 0，，03： | 1 |
| 9 | Fabrication of electrochemical theophylline sensor based on manganese oxide nanoparticles/ionic liquid/chitosan nanocomposite modified glassy carbon electrode显示文摘 | SAMIRA M HAZHIR T ABDOLLAH S | 2014 | Electrochim Acta2014，108，1： | 1 |
| 10 | Postharvest quality and shelf life of some hot pepper varieties显示文摘 | Awole Samira Kebede Woldetsadik Tilahun S Workneh | 2011 | Journal of Food Science and Technology2011，50，5： | 1 |
| 11 | Antibiotic resistance in Gram-negative bacteria isolated from fanned catWsh 显示文摘 | SAMIRA S HOANG N K LE THANH H J L | 2007 | Food Control2007，18，： | 1 |
| 12 | Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption显示文摘 | Samira S Marios C Mariko H | 2005 | Nature2005，434，： | 1 |
| 13 | Increased hexose transport in the roots of tomato plants submitted to prolonged hypoxia显示文摘 | IMINE G BIRINICE R SAMIRA S I | 2009 | Planta2009，230，2： | 1 |
| 14 | Tumor necrosis factor promotes human T-cell development in nonobese diabetic/severe combined immunodeficient mice显示文摘 | Samira S Ferrand C Peled A | 2004 | Stem Cells2004，22，6： | 1 |
| 15 | Immunogenicity,protective efficacy and mechanism of novel CCS adjuvanted influenza vaccine显示文摘 | Even-Or O Samira S Rochlin E | | 0，，39： | 1 |
| 16 | Lack of effect of antipsychotics on BNDF and NGF levels in hippocampus of wistar rats显示文摘 | Samira S Valvassor Laura S | 2008 | Metabolic Brain Disease2008，23，2： | 1 |
| 17 | The Use of Soya Bean,Sunflower and Lupin Seeds in the Preparation of Pro- tein Bases for Nutritious Beverages显示文摘 | Fakhriya S T Samira S M Ahmed S E | 1986 | Journal of the Science of Food and Agriculture1986，37，12： | 1 |
| 18 | Application of SWAT model to investigate nitrate leaching in Hamadan-Bahar Watershed, Iran显示文摘 | A Samira A K Jahangir S F Mousavi | 2010 | Agriculture Ecosystems and Environment2010，139，4： | 1 |
| 19 | A swot analysis of ttACCP imple- mentation in Madagascar 显示文摘 | Samira S Gilles S Patrick G | 2010 | Food Control2010，21，3： | 1 |
| 20 | Trends in the analysis of priority organic pollutants (POPs) in human blood 显示文摘 | Samira S Helena N Jessika H | 2013 | Trends in Analytical Chemistry2013，46，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员