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| 1 | Liver Transplantation in Alcoholic Patients: Impact of an Alcohol Addiction Unit Within a Liver Transplant Center显示文摘 | Giovanni Addolorato Antonio Mirijello Lorenzo Leggio Anna Ferrulli Cristina D’Angelo Gabriele Vassallo Anthony Cossari Giovanni Gasbarrini Raffaele Landolfi Salvatore Agnes Antonio Gasbarrini | 2013 | Alcohol Clin Exp Res2013，，9： | 2 |
| 2 | Reverse time-dependent effect of alphafetoprotein and disease control on survival of patients with Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma显示文摘AIM To characterize the survival of cirrhotic patients with Barcelona Clinic Liver Cancer(BCLC) stage C hepatocellular carcinoma(HCC) and to ascertain the factors predicting the achievement of disease control(DC).METHODS The cirrhotic patients with BCLC stage C HCC evaluated by the Hepatocatt multidisciplinary group were subjected to the investigation. Demographic, clinical and tumor features, along with the best tumor response and overall survival were recorded. RESULTS One hundred and ten BCLC stage C patients were included in the analysis; the median overall survival was 13.4 mo(95%CI: 10.6-17.0). Only alphafetoprotein(AFP) serum level > 200 ng/m L and DC could independently predict survival but in a time dependent manner, the former was significantly associated with increased risk of mortality within the first 6 mo of follow-up(HR = 5.073, 95%CI: 2.159-11.916, P = 0.0002), whereas the latter showed a protective effect against death after one year(HR = 0.110, 95%CI: 0.038-0.314, P < 0.0001). Only patients showing microvascular invasion and/or extrahepatic spread recorded lower chances of achieving DC(OR = 0.263, 95%CI: 0.111-0.622, P = 0.002).CONCLUSION The BCLC stage C HCC includes a wide heterogeneous group of cirrhotic patients suitable for potentially curative treatments. The reverse and time dependent effect of AFP serum level and DC on patients' survival confers them as useful predictive tools for treatment management and clinical decisions. | Francesca Romana Ponziani Irene Spinelli Emanuele Rinninella Lucia Cerrito Antonio Saviano Alfonso Wolfango Avolio Michele Basso Luca Miele Laura Riccardi Maria Assunta Zocco Brigida Eleonora Annicchiarico Matteo Garcovich Marco Biolato Giuseppe Marrone Anna Maria De Gaetano Roberto Iezzi Felice Giuliante Fabio Maria Vecchio Salvatore Agnes Giovanni Addolorato Massimo Siciliano Gian Lodovico Rapaccini Antonio Grieco Antonio Gasbarrini Maurizio Pompili | 2017 | World Journal of Hepatology2017，9，36： | 1 |
| 3 | Recurrence of hepatocellular cancer after liver transplantation: The role of primary resection and salvage transplantation in East and West显示文摘 | Quirino Lai Alfonso W. Avolio Jan Lerut Gurusharan Singh See Ching Chan Pasquale B. Berloco Giuseppe Tisone Salvatore Agnes Kenneth S. Chok William Sharr Massimo Rossi Tommaso M. Manzia Chung Mau Lo | 2012 | Journal of Hepatology2012，，5： | 1 |
| 4 | Recurrence of hepatocellular cancer after liver transplantation: The role of primary resection and salvage transplantation in East and West显示文摘 | Quirino Lai Alfonso W. Avolio Jan Lerut Gurusharan Singh See Ching Chan Pasquale B. Berloco Giuseppe Tisone Salvatore Agnes Kenneth S. Chok William Sharr Massimo Rossi Tommaso M. Manzia Chung Mau Lo | 2012 | Journal of Hepatology2012，，5： | 1 |
| 5 | Liver Match, a prospective observational cohort study on liver transplantation in Italy: Study design and current practice of donor–recipient matching显示文摘 | Mario Angelico Umberto Cillo Stefano Fagiuoli Antonio Gasbarrini Caius Gavrila Tania Marianelli Alessandro Nanni Costa Alessandra Nardi Mario Strazzabosco Patrizia Burra Salvatore Agnes Umberto Baccarani Fulvio Calise Michele Colledan Oreste Cuomo Luciano | 2010 | Digestive and Liver Disease2010，，2： | 1 |
| 6 | Pediatric T-tube in adult liver transplantation:Technical refinements of insertion and removal显示文摘BACKGROUND With the increasing use of extended-criteria donor organs,the interest around Ttubes in liver transplantation(LT)was restored whilst concerns regarding T-tuberelated complications persist.AIM To describe insertion and removal protocols implemented at our institution to safely use pediatric rubber 5-French T-tubes and subsequent outcomes in a consecutive series of adult patients.METHODS Data of consecutive adult LT patients from brain-dead donors,treated from March 2017 to December 2019,were collected(i.e.,biliary complications,adverse events,treatment after T-Tube removal).Patients with upfront hepaticojejunostomy,endoscopically removed T-tubes,those who died or received retransplantation before T-tube removal were excluded.RESULTS Seventy-two patients were included in this study;T-tubes were removed 158 d(median;IQR 128-206 d)after LT.In four(5.6%)patients accidental T-tube removal occurred requiring monitoring only;in 68(94.4%)patients Nelaton drain insertion was performed according to our protocol,resulting in 18(25%)patients with a biliary output,subsequently removed after 2 d(median;IQR 1-4 d).Three(4%)patients required endoscopic retrograde cholangiopancreatography(ERCP)due to persistent Nelaton drain output.Three(4%)patients developed suspected biliary peritonitis,requiring ERCP with sphincterotomy and nasobiliary drain insertion(only one revealing contrast extravasation);no patient required percutaneous drainage or emergency surgery.CONCLUSION The use of pediatric rubber 5-French T-tubes in LT proved safe in our series after insertion and removal procedure refinements. | Gabriele Spoletini Giuseppe Bianco Antonio Franco Francesco Frongillo Erida Nure Francesco Giovinazzo Federica Galiandro Andrea Tringali Vincenzo Perri Guido Costamagna Alfonso Wolfango Avolio Salvatore Agnes | 2021 | World Journal of Gastrointestinal Surgery2021，13，12： | 0 |
| 7 | Development and validation of an artificial intelligence model for predicting post-transplant hepatocellular cancer recurrence显示文摘Dear Editor,In recent years,criteria based on the combinationof morphology and biology have been proposed forimproving the selection of hepatocellular cancer(HCC)patients waiting for liver transplantation(LT)[1,2].Since all the proposed models showed suboptimalresults in predicting the risk of postLT recurrence,aprediction model constructed using artificial intelligence(Al)could be an attractive way to surpass this limit[3,4].Therefore,the Time_Radiological-response_Alpha-fetoproteIN_Artificial-Intelligence(TRAIN-AI)modelwas developed,combining morphology and biology tumorvariables. | Quirino Lai Carmine De Stefano Jean Emond Prashant Bhangui Toru Ikegami Benedikt Schaefer Maria Hoppe-Lotichius Anna Mrzljak Takashi Ito Marco Vivarelli Giuseppe Tisone Salvatore Agnes Giuseppe Maria Ettorre Massimo Rossi Emmanuel Tsochatzis Chung Mau Lo Chao-Long Chen Umberto Cillo Matteo Ravaioli Jan Paul Lerut the EurHeCaLT and the West-East LT Study Group | 2023 | Cancer Communications2023，43，12： | 0 |
| 8 | Breast cancer liver metastasis:time to resection and criteria显示文摘A manuscript recently published by Grazi pools outcomes from data on patients undergoing surgical resection for breast cancer liver metastases(BCLMs).In the manuscript,Grazi shows no definitive proof of liver resections(LR)effectiveness for BCLM.However,the author suggests surgery may be possible in selected patients(1-3).Several retrospective case series have been published evaluating patients’survival following resection for BCLM,reporting results for 5-year overall and disease-free survivals.Grazi tries to make recommendations based on the data that show which patients have a good prognosis following liver surgery.However,the conclusion that surgical treatment is an option with a survival advantage for selected patients is not evident in the current literature as the criteria for surgery are not well established. | Francesco Giovinazzo Angela Bucaro Salvatore Agnes | 2022 | Hepatobiliary Surgery and Nutrition2022，11，5： | 0 |
| 9 | Transjugular portosystemic shunt for early-onset refractory ascites after liver transplantation显示文摘Liver transplantation(LT)is the most effective treatment for end-stage liver disease and complications of portal hypertension(PHT).However,PHT can relapse as a consequence of viral,alcoholic or metabolic chronic liver disease(CLD)recurrence,rejection,vascular abnormalities,small-for-size syndrome and technical complications(e.g.,portal or hepatic veins stenosis and/or thrombosis)[1].LT recipients with PHT may suffer from com plications similarly to non-transplanted cirrhotic patients(e.g.,refractory ascites,variceal hemorrhages and hydrothorax)although with higher morbidity and mortality due to their postoperative status and concomitant immunosuppressive therapy[2]. | Giuseppe Bianco Marco Maria Pascale Francesco Frongillo Erida Nure Salvatore Agnes Gabriele Spoletini | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，1： | 0 |
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