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| 1 | The relevance of serum albumin among elderly patients with acute decompensated heart failure显示文摘Objective To assess the prognostic utility of serum albumin among elderly patients admitted for acute decompensated heart failure(ADHF)in terms of all-cause mortality and also to identify the predictors of hypoalbuminemia.Methods Retrospective cohort study of 119 elderly patients admitted for ADHF.Elderly patients were defined as patients over the age of 65 years.The patients were followed up for approximately 11 years.Patients with advanced renal failure,liver disease not due to HF,cancer and other causes of low life expectancy were excluded.Hypoalbuminemia was defined as serum albumin≤2.9 g/dL.Results The study was made up of 65 females and 54 males with age ranging from 65 to 96 years.Of the 119 elderly patients with ADHF,there were 26 deaths.A significantly higher proportion of patients in the mortality group had an admission serum albumin level of≤2.9 g/dL than those surviving(P=0.011).After Cox’s logistic regression,low albumin(P=0.016),elevated direct bilirubin(P=0.03),age greater than 85(P=0.008),lack of use of beta blockers(P=0.0001)and left ventricular ejection fraction less than 35%(P=0.005)increased the risk of death.Elevated serum creatinine(P=0.0357)was the only predictor of hypoalbuminemia following multiple linear regression.Conclusions Hypoalbuminemia may be an unrecognized marker of death in elderly patients with ADHF. | Tuoyo O Mene-Afejuku Ela-Anamaria Moisa Adedoyin Akinlonu Carissa Dumancas Shushan Veranyan Jose A Perez Peggy Salazar Shobhana Chaudhari Gerald Pekler Savi Mushiyev Ferdinand Visco | 2019 | Journal of Geriatric Cardiology2019，16，7： | 10 |
| 2 | Rare functioning pancreaticendocrine tumors显示文摘 | O′Toole D Salazar R Falconi M | | 0，，03： | 1 |
| 3 | Thermostabilization of a cytochrome P450 peroxygenase显示文摘 | Salazar O Cirino P C Arnold FH | 2003 | Chem Biochem2003，4，9： | 1 |
| 4 | Cyclooxygenase-2 inhibition with celecoxib enhances antitumor efficacy and reduces diarrhea side effect of CPT-11显示文摘 | Trifan O C Durham W F Salazar V S | 2002 | Cancer Res2002，62，20： | 1 |
| 5 | Shortterm lipopolysaccharide stimulation induces differentiation of murine bone marrow-derived dendritic cells into a tolerogenic phenotype 显示文摘 | Salazar L Aravena O Contreras-Levicoy J | 2007 | Eur Cytokine Netw2007，18，2： | 1 |
| 6 | A bearingless method for induction machines显示文摘 | Salazar A O Stephan R M | 1993 | IEEE Transactions on Magnetics1993，29，6： | 1 |
| 7 | Evaluation of DRAINMOD U sing Saturated Hydraulic Conductivity Estimated by a Pedo transfer Function Model 显示文摘 | Salazar O Wesstrom I Joel A | 2008 | Agricultural Water Manage ment2008，95，10： | 1 |
| 8 | Short-term lipopolysaccharide stimulation induces differentiation of murine bone marrow-derived dendritic cells into a tolerogenic phenotype显示文摘 | Salazar L Aravena O Contreras-Levicoy J | 2007 | Eur Cytokine Netw2007，18，2： | 1 |
| 9 | Enzymatic lysis of microbial cells 显示文摘 | Salazar O Asenjo JA | 2007 | Biotechnol Lett2007，29，： | 1 |
| 10 | HP0953-hypothetical virulence factor overexpresion and localization during Helicobacter pylori infection of gastric epithelium显示文摘BACKGROUND The high prevalence and persistence of Helicobacter pylori(H. pylori) infection, as well as the diversity of pathologies related to it, suggest that the virulence factors used by this microorganism are varied. Moreover, as its proteome contains 340hypothetical proteins, it is important to investigate them to completely understand the mechanisms of its virulence and survival. We have previously reported that the hypothetical protein HP0953 is overexpressed during the first hours of adhesion to inert surfaces, under stress conditions, suggesting its role in the environmental survival of this bacterium and perhaps as a virulence factor.AIM To investigate the expression and localization of HP0953 during adhesion to an inert surface and against gastric(AGS) cells.METHODS Expression analysis was performed for HP0953 during H. pylori adhesion. HP0953 expression at 0,3, 12, 24, and 48 h was evaluated and compared using the Kruskal-Wallis equality-of-populations rank test. Recombinant protein was produced and used to obtain polyclonal antibodies for immunolocalization. Immunogold technique was performed on bacterial sections during adherence to inert surfaces and AGS cells, which was analyzed by transmission electron microscopy. HP0953 protein sequence was analyzed to predict the presence of a signal peptide and transmembrane helices, both provided by the ExPASy platform, and using the GLYCOPP platform for glycosylation sites. Different programs, via, I-TASSER, RaptorX, and HHalign-Kbest, were used to perform three-dimensional modeling.RESULTS HP0953 exhibited its maximum expression at 12 h of infection in gastric epithelium cells.Immunogold technique revealed HP0953 localization in the cytoplasm and accumulation in some peripheral areas of the bacterial body, with greater expression when it is close to AGS cells.Bioinformatics analysis revealed the presence of a signal peptide that interacts with the transmembrane region and then allows the release of the protein to the external environment. The programs also showed a similarity with the Tip-alpha protein of H. pylori. Tip-alpha is an exotoxin that penetrates cells and induces tumor necrosis factor alpha production, and HP0953 could have a similar function as posttranslational modification sites were found;modifications in turn require enzymes located in eukaryotic cells. Thus, to be functional, HP0953 may necessarily need to be translocated inside the cell where it can trigger different mechanisms producing cellular damage.CONCLUSION The location of HP0953 around infected cells, the probable posttranslational modifications, and its similarity to an exotoxin suggest that this protein is a virulence factor. | Nancy K Arteaga-Resendiz Gerardo E Rodea Rosa María Ribas-Aparicio Alma L Olivares-Cervantes Juan Arturo Castelán-Vega Joséde Jesús Olivares-Trejo Sandra Mendoza-Elizalde Edgar O López-Villegas Christian Colín Pamela Aguilar-Rodea Alfonso Reyes-López Marcela Salazar García Norma Velázquez-Guadarrama | 2022 | World Journal of Gastroenterology2022，28，29： | 1 |
| 11 | Phylogenetic study of Hypoxylon and related genera based on ribosomal ITS sequences显示文摘 | SANCHEZ-BALLESTEROS J GONZALEZ V SALAZAR O | 2000 | Mycologia2000，92，： | 1 |
| 12 | DSP utilization in radial positioning control of bearingless machine显示文摘 | Ferreira J M S De Paiva J A Salazar A O | 2003 | IEEE International Symposium on Industrial Electronics2003，，1： | 1 |
| 13 | Evaluation of the DRAINMOD-N II model for predicting nitrogen losses in a loamy sand under cultivation in southeast Sweden显示文摘 | SALAZAR O WESSTROM I YOUSSEF M A | 2009 | Agricultural Water Management2009，96，2： | 1 |
| 14 | New designs for radiation oncology research in clinical trials显示文摘 | Rubin P Keys H Salazar O | 1981 | Semin Oncol1981，8，4： | 1 |
| 15 | Enzymatic lysis of microbial cells 显示文摘 | SALAZAR O ASENJO J A | 2007 | Biotechnol Lett2007，29，7： | 1 |
| 16 | Enzymatic lysis of microbial cells显示文摘 | Salazar O Asenjo JA | 2007 | Biotechnol Lett2007，29，7： | 1 |
| 17 | Enzymatic lysis of microbial cells 显示文摘 | SALAZAR O ASENJO J A | 2007 | Biotechnology Letters2007，29，7： | 1 |
| 18 | Modelling discharge from a coastal watershed in southeast Sweden using an integrated framework显示文摘 | Salazar O Joel A Wesstrom I | 2010 | Hydrological Processes2010，24，26： | 1 |
| 19 | A magnetic bearing system using capacitive sensors for position measurement显示文摘 | Salazar A O Dunford W Stephan R | 1990 | IEEE Transactions on Magnetics1990，26，5： | 1 |
| 20 | Periocular Triamcinolone for Prevention of Macular Edema after Plaque Radiotherapy of Uveal Melanoma显示文摘 | Noel Horgan Carol L. Shields Arman Mashayekhi Pedro F. Salazar Miguel A. Materin Myra O’Regan Jerry A. Shields | 2009 | Ophthalmology2009，，7： | 1 |
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