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| 1 | Outcome of 1355 consecutive transabdominal chorionic villus samplings in 1351 patients显示文摘Background The true risk of choronic villus sampling (C VS) is poorly defined. The objective of this study was to review the clinical o utcome of transabdominal CVS performed in a university teaching unit, with an em phasis on the complication rate. Methods A comprehensive audit database was maintained for 1351 pregnant women, including 17 sets of twin pregnancies, who had a CVS. Details a nd outcome of all CVSs made in the unit between May 1996 and May 2004 were revie wed. All CVSs were performed by one of 5 operators using the identical techniqu es. Results All procedures were performed transabdominally. A tota l of 1355 CVSs were performed because there were 4 dichorionic twin pregnancies which required 2 punctures. The mean gestation at CVS was (11.8±0.7) weeks, and 97.3% of the procedures were performed between 11 and 13 completed weeks. The majority (96.2%) required only 1 puncture to achieve correct needle placeme nt. The procedure failed to obtain an adequate sample in 4 subjects (0.30%). A total of 1351 chromosomal studies were requested and there was 1 case (0.07%) of culture failure. The results of chromosomal studies were available within 1 4 days in 36.7% of the cases and within 21 days in 94.0%. Overall, 77 chromos omal abnormalities (5.7%) and 5 cases of thalassemia major were detected. Preg nancy outcome was unknown in only 13 singleton subjects (0.96%). In the remain ing 1355 fetuses, there were 76 pregnancy terminations (5.56%), 10 fetal losses with obvious obstetric causes (0.73%), and 21 potentially procedure-relat ed fetal losses (1.54%). In the last group, the majority had one or more co-e xisting obstetric complications. The background fetal loss rate for pregnancies at similar gestational age in the unit was about 0.8%. Therefore, the procedu re-related fetal loss rate was estimated to be at the maximum of 0.74%. Conclusions In experienced hands, first trimester transabdomina l CVS is an accurate and safe invasive prenatal diagnostic procedure. It should be one of the treatment options available to pregnant women who require prenata l genetic diagnosis. | LAU Tze Kin LEUNG Tak Yeung FUNG Tak Yuen Daljit S SAHOTA LEUNG Tse Ngong | 2005 | Chinese Medical Journal2005，，20： | 8 |
| 2 | 香港助产士完成的中孕期胎儿结构畸形超声筛查——回顾及评价显示文摘目的确定由经过训练的助产士执行的针对低危人群的中孕期胎儿结构畸形超声筛查的效能。方法回顾1所大学附属医院妇产科中由助产士执行的常规中孕期超声筛查结果,共13882例单胎孕妇,分析需转介至母胎医学专家进一步确诊的病例的原因。结果最终分析前排除了189例未知妊娠结局的孕妇。总共有617例(4.51%)转介到母胎医学专家进行进一步确诊,其中470例(70.2%)是因超声软标志,147例(23.8%)是因可疑的胎儿畸形。在这13693个已知妊娠结局的胎儿中,畸形胎儿有185个,发生率1.35%。其中115个在中孕期筛查中被检出,2个在晚孕期检查中被检出。剩下的68例畸形胎儿,大多数是生后发现的微小畸形。中孕期检查畸形胎儿的检出率为62.2%(115/185)(95%CI55.2~69.2)。有4例假阳性,33例误报。结论经过适当训练的有经验的助产士可以检出大多数的胎儿结构畸形。持续的审核及质量控制对优化胎儿结构畸形的检查有明显的作用。 | 陈敏 陈立斌 梁德杨 Sahota Daljit Singh 冯德源 陈连伟 罗丽华 周慕贞 劳子禧 刘子建 | 2010 | 中国产前诊断杂志(电子版)2010，2，2： | 2 |
| 3 | Organizational culture as a knowledge repository for increased innovative capacity显示文摘 | M. Lemon P.S. Sahota | 2003 | Technovation2003，，6： | 1 |
| 4 | An audit of current clinical practice in the management of osteoporosis in Nottingham 显示文摘 | Sahota O Worley A Hosking DJ | 2000 | J Public Health Med2000，22，4： | 1 |
| 5 | Effect of comorbidities and ostoperative complications on mortality after hip fracture in elder- ly people:Prospective observational cohort study 显示文摘 | Roche JJW Wenn RT Sahota O | 2005 | Br Med J2005，331，： | 1 |
| 6 | Shell ETAP high pressure and temperature pipe-in-pipe pipeline design and fabrications显示文摘 | Trout S Sahota B | 1998 | OMAE1998，，： | 1 |
| 7 | Theories of personal income distribution: A survey 显示文摘 | Gian Singh Sahota | 1978 | Journal of Econometric Literature1978，，16： | 1 |
| 8 | Trends in maternal o- besity and assoeiated risks of adverse pregnancy outcomes in a population of Chinese women 显示文摘 | Leung TY Leung TN Sahota DS | 2008 | BJOG2008，115，12： | 1 |
| 9 | Effect of comorbidities and postoperative complications on mortality after hip fracture in elderly people: prospective observational cohort study显示文摘 | ROCHE J J WENN R T SAHOTA O | 2005 | BMJ2005，331，7529： | 1 |
| 10 | Effect of comorbidities and postoperative complications on mortality after hip fracture in elderly People: prospective observational cohort study显示文摘 | ROCHE J J WENN RT SAHOTA O | 2005 | BMJ2005，331，7529： | 1 |
| 11 | Vintamin D insufficiency increases bone turnover markers and enhances bone loss at the hip in patients with established vertebral osteoporosis显示文摘 | Sahota O Masud T San P | 1999 | Cin Endocrinol1999，51，： | 1 |
| 12 | Threatened abortion:prediction of viability based on signs and symptoms显示文摘 | Chung TK Sahota DS Lau TK | 1999 | The Australian & New Zealand Journal of Obstetrics & Gyneacology1999，39，4： | 1 |
| 13 | Postpartum urinary retention显示文摘 | Yip SK Sahota D Pang MW | 2004 | Acta Obstet Gynecol Scand2004，83，： | 1 |
| 14 | Approaches to im- prove angiogenesis in tissue-engineered Skin显示文摘 | Sahota PS Bunr JL Brown N J | 2004 | Wound Re- pair Regen2004，12，6： | 1 |
| 15 | Organizational culture as a knowledge repository for increased innovative capacity显示文摘 | Lemon M Sahota P S | 2004 | Technovation2004，24，6： | 1 |
| 16 | Comparison of fristt- rimester contingent screening strategies for Down syndrome 显示文摘 | Sahota DS Leueg TY Chan LW | 2010 | UItrasound Obstet Gynecol2010，35，3： | 1 |
| 17 | Sleep disorders in pregnancy显示文摘 | Sahota P K Jain S S Dhand R | 2003 | Curr Opin Pulm Med2003，9，6： | 1 |
| 18 | Development of a reconstructed human skin model for angiogenesis 显示文摘 | Sahota PS Burn JL Heaton M | 2003 | Wound Repair Regen2003，11，4： | 1 |
| 19 | An in vivo investigation on the wound-healing effect of two medicinal herbs using an animal model with foot ulcer显示文摘 | Lau TW Sahota DS Lau CH | 2008 | Eur Surg Res2008，41，1： | 1 |
| 20 | Investigational therapies for ischemic stroke:neuroprotection and neurorecovery显示文摘 | Sahota P Savitz SI | | 0，，03： | 1 |
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