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| 1 | Intrahepatic distribution of hepatitis B virus antigens in patients with and without hepatocellular carcinoma显示文摘AIM: To study the intrahepatic expression of hepatitis B surface antigen(HBs Ag) and hepatitis B core antigen(HBc Ag) in chronic hepatitis B patients with and without hepatocellular carcinoma. METHODS: A total of 33 chronic hepatitis B patients(mean age of 40.3 ± 2.5 years), comprising of 14 HBe Ag positive and 19 HBe Ag negative patients; and 13 patients with hepatitis B virus related hepatocellular carcinoma(mean age of 49.6 ± 4.7 years), were included in our study. Immunohistochemical staining for HBc Ag and HBs Ag was done using standard streptavidin-biotin-immunoperoxidase technique on paraffin-embedded liver biopsies. The HBc Agand HBs Ag staining distributions and patterns were described according to a modified classification system. RESULTS: Compared to the HBe Ag negative patients, the HBe Ag positive patients were younger, had higher mean HBV DNA and alanine transaminases levels. All the HBe Ag positive patients had intrahepatic HBc Ag staining; predominantly with 'diffuse' distribution(79%) and 'mixed cytoplasmic/nuclear ' pattern(79%). In comparison, only 5% of the HBe Ag-negative patients had intrahepatic HBc Ag staining. However, the intrahepatic HBs Ag staining has wider distribution among the HBe Ag negative patients, namely; majority of the HBe Ag negative cases had 'patchy' HBs Ag distribution compared to 'rare' distribution among the HBe Ag positive cases. All but one patient with HCC were HBe Ag negative with either undetectable HBV DNA or very low level of viremia. Intrahepatic HBc Ag and HBs Ag were seen in 13(100%) and 10(77%) of the HCC patients respectively. Interestingly, among the 9 HCC patients on anti-viral therapy with suppressed HBV DNA, HBc Ag and HBs Ag were detected in tumor tissues but not the adjacent liver in 4(44%) and 1(11%) patient respectively. CONCLUSION: Isolated intrahepatic HBc Ag and HBs Ag can be present in tumors of patients with suppressed HBV DNA on antiviral therapy; that may predispose them to cancer development. | Parham Safaie Mugilan Poongkunran Ping-Ping Kuang Asad Javaid Carl Jacobs Rebecca Pohlmann Imad Nasser Daryl TY Lau | 2016 | World Journal of Gastroenterology2016，22，12： | 5 |
| 2 | The Crohn’s disease activity index (CDAI) is similarly elevated in patients with Crohn’s disease and in patients with irritable bowel syndrome显示文摘 | C. Lahiff P. Safaie A. Awais M. Akbari L. Gashin S. Sheth A. Lembo D. Leffler A. C. Moss A. S. Cheifetz | 2013 | Aliment Pharmacol Ther2013，，8： | 2 |
| 3 | Prevalence of inhibitors in a population of 1 280 hemophilia a patients in Iran 显示文摘 | Sharifian R Hoseini M Safai R | 2003 | Acta Medica Iranica2003，41，1： | 1 |
| 4 | Cutaneous malignancies of keratinocytic origin显示文摘 | Bagheri M M Safai B | 2001 | Clin Dermatol2001，19，3： | 1 |
| 5 | Podocytopenia and disease severity in IgA nephropathy 显示文摘 | Lemley KV Lafayette RA Safai M | 2002 | Kidney Int2002，61，4： | 1 |
| 6 | Microstructural Investigation of Plasma-Sprayed Aluminum Coatings显示文摘 | Safai S Herman H | | 0，，02： | 1 |
| 7 | Depression in coronary artery disease 显示文摘 | N Safaie AR Jodati M Raooii | 2012 | Journal of Cardiovascular & Thoracic Research2012，4，3： | 1 |
| 8 | Microstructural investigation of plasma-sprayed aluminum coatings 显示文摘 | Safai S Herman H | 1977 | Thin Solid Films1977，45，： | 1 |
| 9 | Podocytopenia and disease severity in IgA nephropathy显示文摘 | Lemley KV Lafayette RA Safai M | 2002 | Kidney Int2002，61，4： | 1 |
| 10 | Proton radiotherapy for childhood ependymoma: initial clinical outcomes and dose compari- sons 显示文摘 | MacDonald SM Safai S Trofimov A | 2008 | Int J Radiat Oncol Biol Phys2008，71，4： | 1 |
| 11 | Proton radiotherapy for pediatric central nervous system germ cell tumors: early clinical outcomes 显示文摘 | Macdonald SM Trofimov A Safai S | 2011 | Int J Radiat Oncol Biol Phys2011，79，1： | 1 |
| 12 | Podocytopenia and disease severity in IgA nephropathy显示文摘 | Lemley KV Lafayette RA Safai M | 2002 | Kidney Int2002，61，： | 1 |
| 13 | Aerosol characteristics during winter fog at Agra,North India显示文摘 | SAFAI P D KEWAT S PANDITHURAI G | 2009 | Journal of Atmospheric Chemistry2009，61，2： | 1 |
| 14 | Source char- acterization for aerosol constituents and changing roles of calcium and ammonium aerosols in the neutralization of aerosol acidity at a semi-urban site in SW India 显示文摘 | SAFAI P D BUDHAVANT K B RAO P S P | 2010 | Atmospheric Research2010，，98： | 1 |
| 15 | Podoeytopenia and disease severity in IgA nephropathy显示文摘 | Lemley KV Lafayette RA Safai M | 2002 | Kidney Int2002，61，4： | 1 |
| 16 | Podocytepenia and disease severity in IgA nephropathy显示文摘 | Lemley KV Lafayette RA Safai M | 2002 | Kidney Int2002，61，： | 1 |
| 17 | Genetic diversity of Iranian AG1-IA isolates of Rhizoctonia solani, the cause of rice sheath blight, using morphological and molecular markers显示文摘 | Khodayari M Safaie N Shamsbakhsh M | 2009 | Journal of Phytopathology2009，157，： | 1 |
| 18 | The effect of Achillea millefolium extract on spermatogenesis of male Wistar rats显示文摘 | Takzare Nasrin Hosseini Mir-Jamal Hamideh Mortazavi Seyedeh Safaie Sahar Moradi Rayhaneh | 2011 | Human and Experimental Toxicology2011，，4： | 1 |
| 19 | Podocytopenia and disease severity in lgA nephropathy 显示文摘 | LEMLEY KV LAFAYETTE RA SAFAI M | 2002 | Kindney lnt2002，61，： | 1 |
| 20 | Podocytopenia and disease severity in IgA nephropathy显示文摘 | Lemley KV Lafayette RA Safai M eta| | 2002 | Kidney Int2002，61，4： | 1 |
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