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| 1 | Fast-tracking regenerative medicine for traumatic brain injury显示文摘Traumatic brain injury remains a global health crisis that spans all demographics,yet there exist limited treatment options that may effectively curtail its lingering symptoms.Traumatic brain injury pathology entails a progression from primary injury to inflammation-mediated secondary cell death.Sequestering this inflammation as a means of ameliorating the greater symptomology of traumatic brain injury has emerged as an attractive treatment prospect.In this review,we recapitulate and evaluate the important developments relating to regulating traumatic brain injury-induced neuroinflammation,edema,and blood-brain barrier disintegration through pharmacotherapy and stem cell transplants.Although these studies of stand-alone treatments have yielded some positive results,more therapeutic outcomes have been documented from the promising area of combined drug and stem cell therapy.Harnessing the facilitatory properties of certain pharmaceuticals with the anti-inflammatory and regenerative effects of stem cell transplants creates a synergistic effect greater than the sum of its parts.The burgeoning evidence in favor of combined drug and stem cell therapies warrants more elaborate preclinical studies on this topic in order to pave the way for later clinical trials. | Brooke Bonsack Matt Heyck Chase Kingsbury Blaise Cozene Nadia Sadanandan Jea-Young Lee Cesar V. Borlongan | 2020 | Neural Regeneration Research2020，15，7： | 5 |
| 2 | Development and validation of an HPLC-MS/MS analytical method for quantitative analysis of TCBA-TPQ,a novel anticancer makaluvamine analog,and application in a pharmacokinetic study in rats显示文摘We have recently designed and synthesized several novel iminoquinone anticancer agents that have entered preclinical development for the treatment of human cancers.Herein we developed and validated a quantitative HPLC-MS/MS analytical method for one of the lead novel anticancer makaluvamine analog,TCBA-TPQ,and conducted a pharmacokinetic study in laboratory rats.Our results indicated that the HPLC-MS/MS method was precise,accurate,and specific.Using this method,we carried out in vitro and in vivo evaluations of the pharmacological properties of TCBA-TPQ and plasma pharmacokinetics in rats.Our results provide a basis for future preclinical and clinical development of this promising anticancer marine analog. | YU Jun-Xian Sukesh Voruganti LI Dan-Dan Jiang-Jiang Qin Subhasree Nag Su Xu Sadanandan E.Velu Wei Wang Ruiwen ZHANG | 2015 | Chinese Journal of Natural Medicines2015，13，7： | 2 |
| 3 | Recent advances in isolation, synthesis, and evaluation of bioactivities of bispyrroloquinone alkaloids of marine origin显示文摘The ocean continues to provide a plethora of unique scaffolds capable of remarkable biological applications. A large number of pyrroloiminoquinone alkaloids, including discorhabdins, epinardins, batzellines, makaluvamines, and veiutamine, have been isolated from various marine organisms. A class of pyrroloiminoquinone-related alkaloids, known as bispyrroloquinones, is the focus of this review article. This family of marine alkaloids, which contain an aryl substituted bispyrroloquinone ring system, includes three subclasses of alkaloids namely, wakayin, tsitsikammamines A-B, and zyzzyanones A-D. Both wakayin and the tsitsikammamines contain a tetracyclic fused bispyrroloiminoquinone ring system, while zyzzyanones contain a fused tricyclic bispyrroloquinone ring system. The unique chemical structures of these marine natural products and their diverse biological properties, including antifungal and antimicrobial activity, as well as the potent, albeit generally nonspecific and universal cytotoxicities, have attracted great interest of synthetic chemists over the past three decades. Tsitsikammamines, wakayin, and several of their analogs show inhibition of topoisomerases. One additional possible mechanism of anticancer activity of tsitsikammamines analogs that has been discovered recently is through the inhibition of indoleamine 2, 3-dioxygenase, an enzyme involved in tumoral immune resistance. This review discusses the isolation, synthesis, and evaluation of bioactivities of bispyrroloquinone alkaloids and their analogs. | NIJAMPATNAM Bhavitavya DUTTA Shilpa VELU Sadanandan E. | 2015 | Chinese Journal of Natural Medicines2015，13，8： | 2 |
| 4 | Association of elevated B--type natriuretic peptide levels with anglographic lindings among patients with unstable angina and non-ST-segment elevation myocardial infarction 显示文摘 | Sadanandan S Cannon CP Chekuri | 2004 | J Am Coll Cardioh 20042004，，： | 1 |
| 5 | Th late open artery hopothesis-a decade late显示文摘 | Buller C Menon V | 2001 | Am Heart J2001，142，3： | 1 |
| 6 | β-adrenoceptor and in-sulin receptor expression in the skeletal muscle of streptozotocin induced diabetic rats:antagonism by vitamin D and curcumin显示文摘 | Xavier S Sadanandan J George N | | 0，，： | 1 |
| 7 | The late open artery hypothesis--a decade later显示文摘 | Sadanandan S Buller C Menon V | 2001 | Am Heart J2001，142，3： | 1 |
| 8 | Association of ele- vated B-type natriuretic peptide levels with angiographic findings among patients with unstable angina and non-ST-segment elevationmyocardial infarction 显示文摘 | Sadanandan S Cannon CP Chekuri K | 2004 | J Am Coll Cardiol2004，44，3： | 1 |
| 9 | Impact assessment of wind generation on the operations of a power system 显示文摘 | SADANANDAN N D NEEDHAM M E HILSON D W | 1983 | IEEE Transactions on Power Apparatus and Systems1983，102，9： | 1 |
| 10 | Association of elevated B-type natriuretic pepfide levels with angiographic findings among pa- tients with unstable angina and non-ST-segment elevation myocardial infarction显示文摘 | Sadanandan S cannon CP Chekuri K | 2004 | J Am Coil Cardio12004，44，3： | 1 |
| 11 | Association of elevated b - type natriuretie peptide levels with angiographic findings among pa- tients with unstable angina and non -- ST segment elevation myocardial infarction显示文摘 | Sadanandan S Cannon CP Cheruri K | 2004 | J Am Coil Cardiol2004，44，3： | 1 |
| 12 | Clinical and angiographic characteristics of patients with combined anterior and inferior ST-segment elevation on the initial electrocardiogram during acute myocardial infarction显示文摘 | Sadanandan S Hochman JS Kolodziej A | 2003 | Am Heart J2003，146，4： | 1 |
| 13 | Multiwalled carbon nanotubes activate NF-kappaB and AP-1 signaling pathways to induce apoptosis in rat lung epithelial cells显示文摘 | RAVICHANDRAN P BALUCHAMY S SADANANDAN B | | 0，，： | 1 |
| 14 | Low dose intravenous immunoglobulins and steroids in toxic epidermal neerolysis: a prospective comparative open-labelled study of 36 eases显示文摘 | Jagadeesan S Sobhanakumari K Sadanandan SM | 2013 | Indian J Dermatol Venereol Leprol2013，79，4： | 1 |
| 15 | Association of elevated B type natriuretic peptide levels with angiographic findings among patients with unstable angina and non-ST segment elevation myocardial infarction显示文摘 | SADANANDAN S CANNON C P CHEKURIK | 2004 | J Am Coll Card2004，44，3： | 1 |
| 16 | Investigation of the syngas flame characteristics at elevated pressures u- sing optical and laser diagnostic methods 显示文摘 | Rajesh Sadanandan Peter Kutne Adam Steinberg | 2011 | flow turbulence and combustion2011，89，2： | 1 |
| 17 | Characterization of ceramic/steel and ceramic/aluminium armors subjected to oblique impact显示文摘 | Sadanandan S Hetherington J G | 1997 | Int J Impact Eng1997，19，6： | 1 |
| 18 | Multiwalled carbon nanotubes activate NF-κB and AP-1 signaling pathways to induce apoptosis in rat lung epithelial cells显示文摘 | Ravichandran P Baluchamy S Sadanandan B | 2010 | Apoptosis2010，15，： | 1 |
| 19 | Laboratory & field evaluation of controlled release formulation of the insect repellents N,N-diethyl-m-toluamide (DEET) & N,N-diethyl phenylacetamide (DEPA) against mosquito vectors 显示文摘 | Sadanandane C Mathew N Jambulingam P | 2001 | Indian J Med Res2001，113，： | 1 |
| 20 | Clinical and angiographic characteristics of patientswith combined anterior and inferior ST-segment ele-vation on the initial electrocardiogram during acutemyocardial infarction 显示文摘 | Sadanandan S Hochman J S Kolodziej A | 2003 | Am Heart J2003，，146： | 1 |
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