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| 1 | Phytochemical analysis and anticancer capacity of Shemamruthaa,a herbal formulation against DMBA-induced mammary carcinoma in rats显示文摘Objective:To investigate the bioactive-constituents of Shemamruthaa(SM),a herbal combination and its therapeutic effects on the mitochondrial functions with reference to lipid peroxidation(LPO),antioxidant status,citric acid cycle enzymes and electron transport chain enzymes in mammary tissues of 7,12-dimethylbenz(a)-anthracene(DMBA)induced mammary carcinoma in rat model.Methods:Adult Female Sprague-Dawley rats were used for the study and were divided into four groups.CroupⅠserved as control and CroupⅡrats were induced mammary carcinoma by administration of DMBA(25 mg/kg b.w.)orally.The normal and cancer-induced rats(GroupⅢ)were treated with SM(400 mg/kg b.w./day)orally by gastric incubation for 14days.CroupⅣrats served as SM-treated control animals.Results:Cancer-induced rats showed a considerably increased level of LPO with concomitant decreased levels of antioxidants,citric acid cycle enzymes,electron transport chain enzymes and cytochrome contents in the mammary tissue.Treatment with SM brought back the aforementioned biochemical parameters to near normal.Conclusions:From the results,it can be inferred that Shemamruthaa possesses significant anticancer effect through its role in attenuation of LPO,prevention of membrane damage and restoring membrane integrity. | Ayyakkannu Purushothaman Elumalai Nandhakumar Panchanatham Sachdanandam | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，12： | 6 |
| 2 | Ameliorating effect of Semecarpus anacardium Linn.nut milk extract on altered glucose metabolism in high fat diet STZ induced type 2 diabetic rats显示文摘Objective:To explore the protective effect of the drug Semecarpus anacardium(S.anacardium) on altered glucose metabolism in diabetic rats.Methods:Type 2 diabetes mellitus was induced by feeding rats with high fat diet followed by single intraperitoneal injection of streptozotocin (STZ)(35 mg/kg b.w.).Seven days after STZ induction,diabetic rats received nut milk extract of S.anacardium Linn.nut milk extract orally at a dosage of 200 mg/kg daily for 4 weeks.The effect of nut milk extract of S.anacardium on blood glucose,plasma insulin,glucose metabolising enzymes and GSK were studied.Results:Treatment with SA extract showed a significant reduction in blood glucose levels and increase in plasma insulin levels and also increase in HOMA-βand decrease in HOMA -IR.The drug significantly increased the activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase activity and increased the glycogen content in liver of diabetic rats while reducing the activities of gluconeogenic enzymes.The drug also effectively ameliorated the alterations in GSK-3 mRNA expression.Conclusions:Overall,the present study demonstrates the possible mechanism of glucose regulation of S.anacardium suggestive of its therapeutic potential for the management of diabetes mellitus. | Haseena Banu Hedayathullah Khan Kaladevi Siddhi Vinayagam Shanthi Palanivelu Sachdanandam Panchanadham | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，12： | 3 |
| 3 | Effect ofplumbagin on some glucose metabolising enzymes studied in rats in experimental hepatoma 显示文摘 | Parimala R Sachdanandam P | 1993 | Mol Cell Biochem1993，125，1： | 1 |
| 4 | Kalpaamruthaa modulates oxidative stress in cardiovascular complication associated with type 2 diabetes mellitus through PKC-β/Akt signaling显示文摘 | Latha R Shanthi P Sachdanandam P | 2013 | Can J Physiol Pharmacol2013，91，11： | 1 |
| 5 | Ameliorating effect of kalpaamruthaa, a siddha preparation in adjuvant induced arthritis in rats with reference to changes in proinflammatory cytokines and acute phase proteins 显示文摘 | Mythilypriya R Sachdanandam P S Sachdanandam P | 2009 | Chem Biol Interact2009，179，23： | 1 |
| 6 | Curative effect of Semecarpus aracardium Linn nut milk extract against adjuvant arthritis-with special reference to bone metabolism显示文摘 | Ramprasath V R Shanthi P Sachdanandam P | | 0，，： | 1 |
| 7 | Amel- iorating effect of Kalpamnruthaa, a Siddha preparation in adjuvant induced arthritis in rats with reference to changes in proinflammatory eytokines and acute phase proteins 显示文摘 | Mythilypriya R Sachdanandam PS Sachdanandam P | 2009 | Chem Biol Interact2009，179，23： | 1 |
| 8 | Augmented efficacy of tamoxifen in rat breast tumorigenesis when gavaged along with riboflavin, niacin, and CoQ10: effects on lipid peroxidation and antioxidants in mitochondria 显示文摘 | Perumal SS Shanthi P Sachdanandam P | 2005 | Chem Biol Interact2005，152，1： | 1 |
| 9 | Salubrious effect of Kalpaamruthaa, a modified indigenous preparation in adjuvantinduced arthritis in rats-A biochemical approach 显示文摘 | Mythilypfiya R Shanthi P Sachdanandam P | 2008 | Chem Biol Interact2008，173，： | 1 |
| 10 | Ameliorating effect of Kalpaamruthaa,a Siddha preparation in adjuvant induced arthritis in rats with reference to changes in proinflammatory cytokines and acute phase proteins显示文摘 | Mythilypriya R Sachdanandam P S Sachdanandam P | 2009 | Chem Biol Interact2009，179，23： | 1 |
| 11 | Kal Paamruthaa modulates oxidative stress in cardiovascular complication assoeiated with type2 dibaetes mellitus through PKC-β/Akt signaling显示文摘 | Latha R Shanthi P Sachdanandam P | 2013 | Can J Physiol Pharmaeol2013，91，11： | 1 |
| 12 | Immunomodulatory and anti-inflammatory effects of semecarpus anacardium LINN nut milk extract in experimental inflammatory conditions显示文摘 | Shanthi P Sachdanandam P | 2006 | Biol Pharm Bull2006，29，4： | 1 |
| 13 | Ameliorating effect of Kalpaamruthaa,a Siddha preparation in adjuvant induced arthritis in rats with reference to changes in proinflammatory cytokines and acute phase proteins显示文摘 | Mythilypriya R Sachdanandam PS Sachdanandam P | | 0，，2： | 1 |
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