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2篇 您的检索式：作者名="Sabina Coletti"

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		题名	作者	年代	出处	被引量
	1	Hemochromatosis in Italy in the last 30 years: Role of genetic and acquired factors显示文摘	Anna Ludovica Fracanzani Alberto Piperno Luca Valenti Mirella Fraquelli Sabina Coletti Alessandra Maraschi Dario Consonni Enzo Coviello Dario Conte Silvia Fargion	2010	Hepatology2010，，2：	1
	2	Revaluation of clinical and histological criteria for diagnosis of dysmetabolic iron overload syndrome显示文摘AIM: To re-evaluate the diagnostic criteria of insulin resistance hepatic iron overload based on clinical, biochemical and histopathological findings. METHODS: We studied 81 patients with hepatic iron overload not explained by known genetic and acquired causes. The metabolic syndrome (MS) was defined according to ATPⅢ criteria. Iron overload was assessed by liver biopsy. Liver histology was evaluated by Ishak's score and iron accumulation by Deugnier's score; steatosis was diagnosed when present in ≥ 5% of hepatocytes. RESULTS: According to transferrin saturation levels, we observed significant differences in the amount of hepatic iron overload and iron distribution, as well as the number of metabolic abnormalities. Using Receiving Operating Curve analysis, we found that the presence of two components of the MS differentiatedtwo groups with a statistically significant different hepatic iron overload (P < 0.0001). Patients with ≥ 2 metabolic alterations and steatosis had lower amount of hepatic iron, lower transferrin saturation and higher sinusoidal iron than patients with < 2 MS components and absence of steatosis. CONCLUSION: In our patients, the presence of ≥ 2 alterations of the MS and hepatic steatosis was associated with a moderate form of iron overload with a prevalent sinusoidal distribution and a normal transferrin saturation, suggesting the existence of a peculiar pathogenetic mechanism of iron accumulation. These patients may have the typical dysmetabolic iron overload syndrome. By contrast, patients with transferrin saturation ≥ 60% had more severe iron overload, few or no metabolic abnormalities and a hemochromatosis-like pattern of iron overload.	Alessia Riva Paola Trombini Raffaella Mariani Alessandra Salvioni Sabina Coletti Silvia Bonfadini Valentina Paolini Matteo Pozzi Rita Facchetti Giorgio Bovo Alberto Piperno	2008	World Journal of Gastroenterology2008，14，30：	0

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