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	题名	作者	年代	出处	被引量
1	Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C显示文摘Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin.Pancytopenia due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been described.We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011.Among 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of AA.Mean age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation.Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.Three patients had pre-treatment hematological abnormalities related to splenomegaly.In six patients,antiviral treatment was interrupted at the onset of hematological abnormalities.Two patients died due to septic complications and one patient due to acute alveolar hemorrhage.The remaining patients recovered.Severe pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver disease.Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications.	Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns	2015	World Journal of Gastroenterology2015，21，17：	4
2	Interferon-Free Regimens in the Liver-Transplant Setting显示文摘	Sabela Lens Martina Gambato María-Carlota Londo?o Xavier Forns	2014	Semin Liver Dis2014，，01：	2
3	显示文摘	Sabela R Paseka I	1990	J Appl Electrochem1990，20，：	1
4	Properties of Ni-Sx electrodes for hydrogen evolution from alkaline medium 显示文摘	Sabela R Paseka I	1990	J Appl Electrechem1990，，20：	1
5	Expression of the antiapoptosis gene, survivin, predicts death from recurrent colorectal carcinoma 显示文摘	SABELA A I MACADAM R C FARMERY S M	2000	Gut2000，46，5：	1
6	Properties of Ni?S x electrodes for hydrogen evolution from alkaline medium显示文摘	R. Sabela I. Paseka	1990	Journal of Applied Electrochemistry1990，，3：	1
7	Properties of Ni-Sx electrodes for hydrogen evolution from alkaline medium显示文摘	PASEKA I	1990	J Appl Electrochem1990，20，5：	1
8	Performance analysis of HPC applications in the cloud 显示文摘	Roberto R Exp6sito Guillermo L Taboada Sabela Ramos	2013	Future Generation Computer Systems2013，29，1：	1
9	Combinations of simple baseline variables accurately predict sustained virological response in patients with recurrent hepatitis C after liver transplantation显示文摘	Gonzalo Crespo José A. Carrión Mairene Coto-Llerena Zoe Mari?o Sabela Lens Sofía Pérez-del-Pulgar Montserrat García-Retortillo Rosa Miquel Jaime Bosch Miquel Navasa Xavier Forns	2013	Journal of Gastroenterology2013，，6：	1
10	Properties of Ni-Sx electrodes for hydrogen evolution from alkaline medium 显示文摘		1990	J Appl Electrochem1990，20，：	1
11	Properties of Ni?S x electrodes for hydrogen evolution from alkaline medium显示文摘	R. Sabela I. Paseka	1990	Journal of Applied Electrochemistry1990，，3：	1
12	Iron Ores Mix Prepara tion for Sintering Process 显示文摘	Sabela W Budzik R Stanicki S	1997	Metallurgy Metallurgical Engi neering News1997，，6：	1
13	Properties of Ni-Sx electrodes for hydrogen evolution from alkaline medium 显示文摘	Sabela R Paseka I	1990	J Appl Electrochem1990，20，5：	1
14	Efficacy of new direct acting antivirals in transplant recipients and patients with advanced disease显示文摘	Sabela Lens Zoe Mari?o Xavier Forns	2014	Digestive and Liver Disease2014，，：	1
15	The relationship between health-related quality-of life and disability in patients with controlled epilepsy a cross-sectional observational study显示文摘	Rui Quintas Ana Sabela Alvarez Eleni Koutsogeorgou	2012	American Journal of Physical Medicine and Rehabilitation2012，91，2：	1
16	Treatment options in patients with decompensated cirrhosis, pre- and post-transplantation显示文摘	Martina Gambato Sabela Lens Miquel Navasa Xavier Forns	2014	Journal of Hepatology2014，，1：	1
17	Properties of Ni?S x electrodes for hydrogen evolution from alkaline medium显示文摘	R. Sabela I. Paseka	1990	Journal of Applied Electrochemistry1990，，3：	1
18	Interferon free regimens for the “difficult-to-treat”: Are we there?显示文摘	Maria-Carlota Londo?o Sabela Lens Xavier Forns	2013	Journal of Hepatology2013，，4：	1
19	The Addition of a Protease Inhibitor Increases the Risk of Infections in Patients with Hepatitis C-Related Cirrhosis显示文摘	Maria-Carlota Londo?o Christie Perelló Joaquín Cabezas Nuria Ca?ete Sabela Lens Zoe Mari?o Martina Gambato Raquel Rodríguez Susana Menéndez José A. Carrión Javier Crespo José Luis Calleja Xavier Forns	2014	Journal of Hepatology2014，，：	1
20	Properties of Ni?S x electrodes for hydrogen evolution from alkaline medium显示文摘	R. Sabela I. Paseka	1990	Journal of Applied Electrochemistry1990，，3：	1

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