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| 1 | SmMYB2 promotes salvianolic acid biosynthesis in the medicinal herb Salvia miltiorrhiza显示文摘MYB transcription factors play vital roles in plant growth and metabolism.The phytohormone methyl jasmonate(MeJA)promotes phenolic acid accumulation in the medicinal herb Salvia miltiorrhiza,but the regulatory mechanism is poorly understood.Here,we identified the MeJA-responsive R2R3-MYB transcription factor gene 5mMYB2 from a transcriptome library produced from MeJAtreated S.mi'/horr/ifza hairy roots.Sm/VIYB2 expression was tightly correlated with the expression of key salvianolic acid biosynthetic genes including CYP^8Ai^.5mMYB2 was highly expressed in the periderm of S.miltiorrhiza and SmMYB2 localized to the nucleus.Overexpressing Sml\AYB2 in S.miltiorrhiza hairy roots significantly increased the levels of salvianolic acids(including rosmarinic acid and salvianolic acid B)by upregulating salvianolic acid biosynthetic genes such as CYP98A14.SmMYB2 binds to the MYB-binding motifs in the promoter of CYP98A14,as confirmed by a dual-luciferase assay and electrophoretic mobility shift assays.Anthocyanin contents were significantly higher in Sm/ViyB2-overexpressing hairy root lines than the control,primarily due to the increased expression of CHI,DFR,and ANS.These findings reveal the novel regulatory role of SmMYB2 in MeJA-mediated phenolic acid biosynthesis,providing a useful target gene for metabolic engineering and shedding light on the salvianolic acid regulatory network. | Changping Deng Yao Wang Fenfen Huang Sunjie Lu Limei Zhao Xingyuan Ma Guoyin Kai | 2020 | Journal of Integrative Plant Biology2020，62，11： | 6 |
| 2 | Study on the Genetic Susceptibility of HLA-DRB1 Alleles in Esophageal Neoplasm of Hubei Hans Chinese显示文摘 | LinJun DengChang-sheng SunJie ZhouYan XiongPing WangYa-ping | 2000 | 胃肠病学2000，5，B08： | 3 |
| 3 | The methyl jasmonate-responsive transcription factor SmMYB1 promotes phenolic acid biosynthesis in Salvia miltiorrhiza显示文摘Water-soluble phenolic acids are major bioactive compounds in the medicinal plant species Salvia miltiorrhiza.Phenolic acid biosynthesis is induced by methyl jasmonate(MeJA)in this important Chinese herb.Here,we investigated the mechanism underlying this induction by analyzing a transcriptome library of S.miltiorrhiza in response to MeJA.Global transcriptome analysis identified the MeJA-responsive R2R3-MYB transcription factor-encoding gene SmMYB1.Overexpressing SmMYB1 significantly promoted phenolic acid accumulation and upregulated the expression of genes encoding key enzymes in the phenolic acid biosynthesis pathway,including cytochrome P450-dependent monooxygenase(CYP98A14).Dual-luciferase(dual-LUC)assays and/or an electrophoretic mobility shift assays(EMSAs)indicated that SmMYB1 activated the expression of CYP98A14,as well as the expression of genes encoding anthocyanin biosynthesis pathway enzymes,including chalcone isomerase(CHI)and anthocyanidin synthase(ANS).In addition,SmMYB1 was shown to interact with SmMYC2 to additively promote CYP98A14 expression compared to the action of SmMYB1 alone.Taken together,these results demonstrate that SmMYB1 is an activator that improves the accumulation of phenolic acids and anthocyanins in S.miltiorrhiza.These findings lay the foundation for in-depth studies of the molecular mechanism underlying MeJA-mediated phenolic acid biosynthesis and for the metabolic engineering of bioactive ingredients in S.miltiorrhiza. | Wei Zhou Min Shi Changping Deng Sunjie Lu Fenfen Huang Yao Wang Guoyin Kai | 2021 | Horticulture Research2021，8，1： | 3 |
| 4 | ChemicalconstituentsfromthepollenofPinusmassoniana显示文摘 | LIL SUNJ SUNJY etal | 2010 | 中草药2010，41，4： | 1 |
| 5 | Homogenous Asymmetric Hydrogenation显示文摘 | Caplar V Comisso G Sunji c V | 1981 | Synthesis1981，，2： | 1 |
| 6 | 显示文摘 | SUNJie CHENXi-lei SUNDao-xing(孙杰 陈希磊 孙道兴) | 2012 | 化学工程与装备2012，，3： | 1 |
| 7 | Distribution of Dugong dugonin Coastal Areas in China(儒艮在中国近海的分布)[J]显示文摘 | WANGPL(王丕烈) SUNJY(孙建运) | 1996 | 兽类学报1996，16，3： | 1 |
| 8 | CatalyticdegradationofX3Bbytitaniumdioxidenanotubeswithdifferentlightsource[J]显示文摘 | SunJie(孙杰) YanXin(闫欣) PanHuimin(潘慧敏) | | 中南民族大学学报自科版0，，： | 1 |
| 9 | Effects of NaC1 stress on soluble protein of Lycium barbarum L callus[J]显示文摘 | MAOGuilian(毛桂莲) HAXinfang(哈新芳) SUNJie(孙婕) etal | 2005 | 宁夏大学学自学版2005，26，1： | 1 |
| 10 | Perpyrrospirone A, an unprecedented hirsutellone peroxide from the marine-derived Penicillium citrinum显示文摘Perpyrrospirone A(1) characterized an unprecedented 6/5/6/8/5/13/6 oxahexacyclic scaffold with a unique peroxide-bridged 8,9-dioxa-2-azaspiro[4.7]dodecane core from marine-derived Penicillium citrinum. Compounds 2 and 3 possessed rare oxatetracyclic(6/5/6/5) skeleton fused with a 13-menberedring macrocyclic moiety. Their structure and absolute configurations were determined by comprehensive spectroscopic analyses, ECD data coupled with TD-DFT calculations and X-ray diffraction experiments. In addition, 7 showed cytotoxicity and induced apoptosis of Hela cells in a dose-dependent manner after a48 h treatment. | Yi Ding Yu Jiang Sunjie Xu Xiujuan Xin Faliang An | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
| 11 | Metformin promotes osteogenic differentiation and prevents hyperglycaemia-induced osteoporosis by suppressing PPARγ expression显示文摘Metformin can prevent hyperglycaemia-induced osteoporosis and decrease the bone fracture rate,but the mechanism has not been fully elucidated.To reveal the mechanism by which metformin affects hyperglycaemiainduced osteoporosis,we treat a mouse osteoporosis cell model with metformin and find that osteoblast mineralization increases and PPAR expression decreases.Single-cell mRNA sequencing analysis show that PPARγ is highly expressed in the bone tissue of osteoporosis patients,which highlights the role of PPARγ in osteoporosis.Furthermore,we find that PPARγ is the effector through which metformin prevents osteoporosis.We further examine the mechanism of PPARγ regulation and reveal that metformin regulates PPARγ expression through the AMPK pathway and that PPAR affects osteoblasts through the endoplasmic reticulum stress(ERS)pathway.Moreover,we verify the association between the effect of metformin on bone metabolism and the expression of PPARy in high-fat diet-induced diabetic rats.Thus,we identify and functionally validate that metformin prevents hyperglycaemia-induced osteoporosis by regulating the AMPK-PPARγ-ERS axis. | Lifeng Zheng Ximei Shen Yun Xie Hong Lian Sunjie Yan Shizhong Wang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，3： | 0 |
| 12 | Study of the Association of HLA-DRB1 Alleles with Clinic Features and Helicobacter pylori Infection in Hubei Hart Chinese Patients with Gastric Adenocarcinoma显示文摘 | LinJun DengChang-sheng SunJie XiongPing WangYa-ping XiaoJian-qun | 2000 | 胃肠病学2000，5，B08： | 0 |
| 13 | HLA-DRB1 Alleles Involved in the Genetic Susceptibility to Stomach Neoplasm in Hubei Hans显示文摘 | DengChang-sheng LinJun WangYa-ping SunJie XiongPing ZhouYan | 2000 | 胃肠病学2000，5，B08： | 0 |
| 14 | The Study of the Reference Values of 24 Hour Esophageal Monitoring in Chinese Healthy Adults and its Application in Esophageal Reflux Disease显示文摘 | LmJun DengChang-sheng SunJie | 2000 | 胃肠病学2000，5，B08： | 0 |
| 15 | HLA-DQB1 Alleles Involved in the Genetic Susceptibility to Gastric Neoplasm in Hubei Han显示文摘 | LinJun DengChang-sheng WangYa-ping SunJie XiongPing ZhouYan | 2000 | 胃肠病学2000，5，B08： | 0 |
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