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| 1 | Relationships between the North Pacific Oscillation and the typhoon/hurricane frequencies显示文摘Relationships between the North Pacific Oscillation (NPO) and the typhoon as well as hurricane fre-quencies are documented. The correlation between NPO index in June-July-August-September and the annual typhoon number in the western North Pacific is 0.37 for the period of 1949―1998. The NPO is correlated with the annual hurricane number in the tropical Atlantic at -0.28 for the same period. The variability of NPO is found to be concurrent with the changes of the magnitude of vertical zonal wind shear, sea-level pressure patterns, as well as the sea surface temperature, which are physically asso- ciated with the typhoons and hurricanes genesis. The NPO associated atmospheric circulation vari- ability is analyzed to explain how NPO is linked with variability of the tropical atmospheric circulation in the western Pacific and the tropical Atlantic, via the atmospheric teleconnection. | WANG HuiJun SUN JianQi FAN Ke | 2007 | Science China Earth Sciences2007，50，9： | 37 |
| 2 | “Volume-point” heat conduction constructal optimization based on entransy dissipation rate minimization with three-dimensional cylindrical element and rectangular and triangular elements on microscale and nanoscale显示文摘Based on constructal theory,the constructs of three 'volume-point' heat conduction models with three-dimensional cylindrical element and rectangular and triangular elements on microscale and nanoscale are optimized by taking minimum entransy dissipation rate as optimization objective.The optimal constructs of the three 'volume-point' heat conduction models with minimum dimensionless equivalent thermal resistance are obtained.The results show that the optimal constructs of the three-dimensional cylindrical assembly based on the minimizations of dimensionless equivalent thermal resistance and dimensionless maximum thermal resistance are different,which is obviously different from the comparison between those of the corresponding two-dimensional rectangular assembly based on the minimizations of these two objectives.The optimal constructs based on rectangular and triangular elements on microscale and nanoscale when the size effect takes effect are obviously different from those when the size effect does not take effect.Because the thermal current density in the high conductivity channel of the rectangular and triangular second order assemblies are not linear with the length,the optimal constructs of these assemblies based on the minimization of entransy dissipation rate are different from those based on the minimization of maximum temperature difference.The dimensionless equivalent thermal resistance defined based on entransy dissipation rate reflects the average heat transfer performance of the construct.The studies on 'volume-point' heat conduction constructal problems at three-dimensional conditions and microscale and nanoscale by taking minimum entransy dissipation rate as optimization objective extend the application range of the entransy dissipation extremum principle. | FENG HuiJun CHEN LinGen SUN FengRui | 2012 | Science China(Technological Sciences)2012，55，3： | 20 |
| 3 | A Review of Seasonal Climate Prediction Research in China显示文摘The ultimate goal of climate research is to produce climate predictions on various time scales. In China, efforts to predict the climate started in the 1930 s. Experimental operational climate forecasts have been performed since the late 1950 s,based on historical analog circulation patterns. However, due to the inherent complexity of climate variability, the forecasts produced at that time were fairly inaccurate. Only from the late 1980 s has seasonal climate prediction experienced substantial progress, when the Tropical Ocean and Global Atmosphere project of the World Climate Research program(WCRP) was launched. This paper, following a brief description of the history of seasonal climate prediction research, provides an overview of these studies in China. Processes and factors associated with the climate variability and predictability are discussed based on the literature published by Chinese scientists. These studies in China mirror aspects of the climate research effort made in other parts of the world over the past several decades, and are particularly associated with monsoon research in East Asia. As the climate warms, climate extremes, their frequency, and intensity are projected to change, with a large possibility that they will increase. Thus, seasonal climate prediction is even more important for China in order to effectively mitigate disasters produced by climate extremes, such as frequent floods, droughts, and the heavy frozen rain events of South China. | WANG Huijun FAN Ke SUN Jianqi LI Shuanglin LIN Zhaohui ZHOU Guangqing CHEN Lijuan LANG Xianmei LI Fang ZHU Yali CHEN Hong ZHENG Fei | 2015 | Advances in Atmospheric Sciences2015，32，2： | 20 |
| 4 | Relationship between Arctic Oscillation and Pacific Decadal Oscillation on decadal timescale显示文摘The relationship between the Pacific Decadal Oscillation (PDO) and the Arctic Oscillation (AO) on decadal timescale in the extended winter (November-March) is investigated in this study. The results indicate that AO plays an important role in the low frequency variability of PDO. When AO leads PDO by 7-8 years, the lagging correlation between them becomes the strongest with correlation coeffi- cient 0.77. The leading decadal variability of AO pro- vides a valuably precursory signal for predicting the variability of PDO. The results of regression and lag- ging correlation reveal the possible mechanism for the AO-PDO coupling: A strong AO would lead to an enhanced Aleutian Low that is linked to PDO by ocean-atmosphere interaction in the North Pacific, and vice versa. | SUN Jianqi WANG Huijun | 2006 | Chinese Science Bulletin2006，51，1： | 19 |
| 5 | Constructal entransy dissipation rate minimization for leaf-like fins显示文摘Based on constructal theory,the constructs of the leaf-like fins are optimized by taking minimum entransy dissipation rate(for the fixed total thermal current,i.e.,the equivalent thermal resistance) as optimization objective.The optimal constructs of the leaf-like fins with minimum dimensionless equivalent thermal resistance are obtained.The results show that there exists an optimal elemental leaf-like fin number,which leads to an optimal global heat conduction performance of the first order leaf-like fin.The Biot number has little effects on the optimal elemental fin number,optimal ratios of length and width of the elemental and first order leaf-like fins;with the increase of the thermal conductivity ratio of the vein and blade,the optimal elemental fin number and optimal ratio of the length and width of the elemental leaf-like fin increase,and the optimal shape of the first order leaf-like fin becomes tubbier.The optimal construct based on entransy dissipation rate minimization is obviously different from that based on maximum temperature difference minimization.The dimensionless equivalent thermal resistance based on entransy dissipation rate minimization is reduced by 11.54% compared to that based on maximum temperature difference minimization,and the global heat conduction performance of the leaf-like fin is effectively improved.For the same volumes of the elemental and first order leaf-like fins,the minimum dimensionless equivalent thermal resistance of the first order of the leaf-like fin is reduced by 30.10% compared to that of the elemental leaf-like fin,and the global heat conduction performance of the first order leaf-like fin is obviously better than that of the elemental leaf-like fin.Essentially,this is because the temperature gradient field of the first order leaf-like fin based on entransy dissipation rate minimization is more homogenous than that of the elemental leaf-like fin.The dimensionless equivalent thermal resistance defined based on entransy dissipation rate reflects the average heat transfer performance of the leaf-like fin,and can provide some guidelines for the thermal design of the fins from the viewpoint of heat transfer optimization. | FENG HuiJun CHEN LinGen SUN FengRui | 2012 | Science China(Technological Sciences)2012，55，2： | 19 |
| 6 | Constructal entransy optimizations for insulation layer of steel rolling reheating furnace wall with convective and radiative boundary conditions显示文摘Based on the entransy dissipation extremum principle for thermal insulation process,the constructal optimizations for a plane insulation layer of the steel rolling reheating furnace wall with convective and radiative boundary conditions are carried out by taking the minimization of entransy dissipation rate as optimization objective.The optimal construct of the plane insulation layer is obtained.The results show that for the convective heat transfer boundary condition,the optimal constructs of the insulation layer obtained based on the minimizations of the entransy dissipation rate and heat loss rate are obviously different.Comparing the optimal construct obtained based on the minimization of the entransy dissipation rate with that based on the minimization of the heat loss rate,the entransy dissipation rate is reduced by 5.98%,which makes the global thermal insulation performance of the insulation layer improve.For the combined convective and radiative heat transfer boundary condition,compared the insulation layer having an increasing thickness with that having constant thickness and a decreasing thickness,the entransy dissipation rates are reduced by 16.59%and39.72%,respectively,and the global thermal insulation performance of the insulation layer is greatly improved.There exits an optimal constant coefficient a2;optwhich leads to the minimum dimensionless entransy dissipation rate of the insulation layer.The difference between the optimal constant coefficients a2;optobtained based on the minimizations of the entransy dissipation rate and the maximum temperature gradient of the insulation layer is small.This makes the corresponding thermal stress obtained based on the minimum dimensionless entransy dissipation rate also be small,and the global thermal insulation performance and thermal safety of the insulation layer are improved simultaneously.The results obtained can provide some guidelines for the optimal designs of the insulation layers. | Huijun Feng Lingen Chen Zhihui Xie Fengrui Sun | 2014 | Chinese Science Bulletin2014，59，20： | 19 |
| 7 | LncRNA SNHG5/miR-26a/SOX2 signal axis enhances proliferation of chondrocyte in osteoarthritis显示文摘Chondrocyte 在骨关节炎(OA ) 涉及关节的破坏病人。这研究的目的是探索小核仁的 RNA 主机基因 5 的表达式水平(SNHG5 ) 并且在 chondrocyte 评估它的函数。在我们的当前的学习, SNHG5 的表示层次, miR-26a,和在 17 关节的软骨纸巾并且在 non-OA 的 SOX2,组被即时量的反向抄写的聚合酶链反应估计。结果证明 SNHG5 和 SOX2 的层次是显著地在 OA 纸巾的 downregulated,当 miR-26a 的水平是 upregulated 时。MTT,殖民地形成和房间 transwell 试金被执行在 CHON-001 房间在房间生存能力,生长能力,和迁居能力上估计 SNHG5 的功能。SNHG5 能支持 chondrocyte 房间增长和移植,这被发现。在 SNHG5 和 miR-26a 之间的关系被证实由裂开并且酶记者试金。SOX2 被酶记者试金作为 miR-26a 的目标基因识别。营救试金被使用在 SNHG5, miR-26a,和 SOX2 之中验证关系。我们的当前的学习证明 SNHG5 通过作为 ceRNA 工作因此,竞争地擦掉 miR-26a 调整 SOX2 的表示涉及 OA 的机制。 | Huijun Shen Yue Wang Wudan Shi Guoxun Sun Luojia Hong Ying Zhang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 18 |
| 8 | Constructal optimization for H-shaped multi-scale heat exchanger based on entransy theory显示文摘Analogizing with the definition of thermal efficiency of a heat exchanger,the entransy dissipation efficiency of a heat exchanger is defined as the ratio of dimensionless entransy dissipation rate to dimensionless pumping power of the heat exchanger.For the constraints of the total tube volume and total tube surface area of the heat exchanger,the constructal optimization of an H-shaped multi-scale heat exchanger is carried out by taking entransy dissipation efficiency maximization as optimization objective,and the optimal construct of the H-shaped multi-scale heat exchanger with maximum entransy dissipation efficiency is obtained.The results show that for the specified total tube volume of the heat exchanger,the optimal constructs of the first order T-shaped heat exchanger based on the maximizations of the thermal efficiency and entransy dissipation efficiency are obviously different with the lower mass flow rates of the cold and hot fluids.For the H-shaped multi-scale heat exchanger,the entransy dissipation efficiency decreases with the increase in mass flow rate when the heat exchanger order is fixed;for the specified dimensionless mass flow rate M(M<32.9),the entransy dissipation efficiency decreases with the increase in the heat exchanger order.The performance of the multi-scale heat exchanger is obviously improved compared with that of the single-scale heat exchanger.Moreover,the heat exchanger subjected to the total tube surface area constraint is also discussed in the paper.The optimization results obtained in this paper can provide a great compromise between the heat transfer and flow performances of the heat exchanger,provide some guidelines for the optimal designs of heat exchangers,and also enrich the connotation of entransy theory. | FENG HuiJun CHEN LinGen XIE ZhiHui SUN FengRui | 2013 | Science China(Technological Sciences)2013，56，2： | 16 |
| 9 | Constructal entransy dissipation rate minimization for helm-shaped fin with inner heat sources显示文摘A model of three-dimensional helm-shaped body composed of a helm-shaped fin and inner heat sources is built in this paper. For the specified volumes of the body, fin and heat source, the constructal optimizations of the body with single and multiple inner heat sources are implemented. The entransy-dissipation-rate-based equivalent thermal resistance(ETR) is minimized in the optimizations. It shows that for the helm-shaped body with multiple inner heat sources, there exist an optimal ratio of the heat source distance to the radius of the extended fin and a twice optimal radius ratio of the centre fin to the extended fin which lead to the double minimum dimensionless ETR. Comparing the optimal result of the body with helm-shaped fin with that with annular fin, the radius of the centre fin and the distance between the heat source and the center of the body are decreased, and the ETR is decreased by 9.57%. Essentially, the temperature gradient field of the helm-shaped body is more homogenous, and its global heat transfer performance is improved. | FENG HuiJun CHEN LinGen XIE ZhiHui SUN FengRui | 2015 | Science China(Technological Sciences)2015，58，6： | 14 |
| 10 | Thermal insulation constructal optimization for steel rolling reheating furnace wall based on entransy dissipation extremum principle显示文摘Analogizing with the heat conduction process, the entransy dissipation extremum principle for thermal insulation process can be described as: for a fixed boundary heat flux (heat loss) with certain constraints, the thermal insulation process is optimized when the entransy dissipation is maximized (maximum average temperature difference), while for a fixed boundary temperature, the thermal insulation process is optimized when the entransy dissipation is minimized (minimum average heat loss rate). Based on the constructal theory, the constructal optimizations of a single plane and cylindrical insulation layers as well as multi-layer insulation layers of the steel rolling reheating furnace walls are carried out for the fixed boundary temperatures and by taking the minimization of entransy dissipation rate as optimization objective. The optimal constructs of these three kinds of insulation structures with distributed thicknesses are obtained. The results show that compared with the insulation layers with uniform thicknesses and the optimal constructs of the insulation layers obtained by minimum heat loss rate, the optimal constructs of the insulation layers obtained by minimum entransy dissipation rate are obviously different from those of the former two insulation layers; the optimal constructs of the insulation layers obtained by minimum entransy dissipation rate can effectively reduce the average heat loss rates of the insulation layers, and can help to improve their global thermal insulation performances. The entransy dissipation extremum principle is applied to the constructal optimizations of insulation systems, which will help to extend the application range of the entransy dissipation extremum principle. | FENG HuiJun CHEN LinGen XIE ZhiHui SUN FengRui | 2012 | Science China(Technological Sciences)2012，55，12： | 14 |
| 11 | Generalized constructal optimization for the secondary cooling process of slab continuous casting based on entransy theory显示文摘Based on constructal theory and entransy theory,a generalized constructal optimization of a solidification heat transfer process of slab continuous casting for a specified total water flow rate in the secondary cooling zone was carried out.A complex function was taken as the optimization objective to perform the casting.The complex function was composed of the functions of the entransy dissipation and surface temperature gradient of the slab.The optimal water distribution at the sections of the secondary cooling zone were obtained.The effects of the total water flow rate in the secondary cooling zone,casting speed,superheat and water distribution on the generalized constructal optimizations of the secondary cooling process were analyzed.The results show that on comparing the optimization results obtained based on the optimal water distributions of the 8 sections in the secondary cooling zone with those based on the initial ones,the complex function and the functions of the entransy dissipation and surface temperature gradient after optimization decreased by 43.25%,5.90%and 80.60%,respectively.The quality and energy storage of the slab had obviously improved in this case.The complex function,composed of the functions of the entransy dissipation and surface temperature gradient of the slab,was a compromise between the internal and surface temperature gradients of the slab.Essentially,it is also the compromise between energy storage and quality of the slab.The'generalized constructal optimization'based on the minimum complex function can provide an optimal alternative scheme from the point of view of improving energy storage and quality for the parameter design and dynamic operation of the solidification heat transfer process of slab continuous casting. | FENG HuiJun CHEN LinGen XIE ZhiHui DING ZeMin SUN FengRui | 2014 | Science China(Technological Sciences)2014，57，4： | 14 |
| 12 | Symbiosis of Marshes and Permafrost in Da and Xiao Hinggan Mountains in Northeastern China显示文摘Recently,the degradation of permafrost and marsh environments in the Da and Xiao Hinggan Mountains has become a great concern as more human activities and pronounced climate warming were observed during the past 30 years and projected for the near future.The distribution patterns and development mechanisms of the permafrost and marshes have been examined both in theories and in field observations,in order to better understand the symbiosis of permafrost and marshes.The permafrost and marshes in the Da and Xiao Hinggan Mountains display discernible zonations in latitude and elevation.The marsh vegetation canopy,litter and peat soil have good thermal insulation properties for the underlying permafrost,resulting in a thermal offset of 3℃ to 4℃ and subsequently suppressing soil temperature.In addition,the much higher thermal conductivity of frozen and ice-rich peat in the active layer is condu-cive to the development or in favor of the protection of permafrost due to the semi-conductor properties of the soils overlying the permafrost.On the other hand,because permafrost is almost impervious,the osmosis of water in marsh soils can be effectively reduced,timely providing water supplies for helophytes growth or germination in spring.In the Da and Xiao Hinggan Mountains,the permafrost degradation has been accelerating due to the marked climate warming,ever increasing human activities,and the resultant eco-environmental changes.Since the permafrost and marsh envi-ronments are symbiotic and interdependent,they need to be managed or protected in a well-coordinated and integrated way. | JIN Huijun SUN Guangyou YU Shaopeng JIN Rui HE Ruixia | 2008 | Chinese Geographical Science2008，18，1： | 13 |
| 13 | Constructal optimization of cylindrical heat sources with forced convection based on entransy dissipation rate minimization显示文摘Based on constructal theory and entransy theory,the optimal designs of constant-and variable-cross-sectional cylindrical heat sources are carried out by taking dimensionless equivalent resistance minimization as optimization objective.The effects of the cylindrical height,the cylindrical shape and the ratio of thermal conductivity of the fin to that of the heat source are analyzed.The results show that when the volume of the heat source is fixed,there exists an optimal ratio of the center-to-centre distance of the fin and the heat source to the cylinder radius which leads to the minimum dimensionless equivalent thermal resistance.With the increase in the height of the cylindrical heat source and the ratio of thermal conductivity,the minimum dimensionless equivalent thermal resistance decreases gradually.For the heat source model with inverted variable-cross-sectional cylinder,there exist an optimal ratio of the center-to-centre distance of the fin and the heat source to the cylinder radius and an optimal radius ratio of the smaller and bigger circles of the cylindrical fin which lead to a double minimum dimensionless equivalent thermal resistance.Therefore,the heat transfer performance of the cylindrical heat source is improved by adopting the cylindrical model with variable-cross-section.The optimal constructs of the cylindrical heat source based on the minimizations of dimensionless maximum thermal resistance and dimensionless equivalent thermal resistance are different.When the thermal security is ensured,the optimal construct of the cylindrical heat source based on minimum equivalent thermal resistance can provide a new alternative scheme for the practical design of heat source.The results obtained herein enrich the work of constructal theory and entransy theory in the optimal design field of the heat sources,and they can provide some guidelines for the designs of practical heat source systems. | GONG ShuWen CHEN LinGen XIE ZhiHui FENG HuiJun SUN FengRui | 2016 | Science China(Technological Sciences)2016，59，4： | 12 |
| 14 | Constructal entransy dissipation rate minimization of a rectangular body with nonuniform heat generation显示文摘Based on construtal theory, a nonuniform heat generation problem in a rectangular body is investigated in this paper. Entransy dissipation rate(EDR) is taken as the optimization objective. The optimal body shapes with constant and variable widths of the high conductivity channel(HCC) are derived. For the rectangular first order assembly(RFOA) with constant cross-section HCC, the shape of the RFOA and width ratio of the HCCs are optimized, and the double minimum EDR is obtained. The heat transfer performance of the RFOA becomes worse when the nonuniform coefficient increases. For the RFOA with variable cross-section HCC, the EDR of the RFOA can be minimized for four times. Compared the optimal construct based on minimum EDR of the RFOA with that based on minimum maximum temperature difference, the shape of the former optimal construct is tubbier, and the average temperature difference is lower. In the practical design of electronic devices, when the thermal safety is ensured, the constructal design scheme of the former optimal construct can be adopted to improve the global heat transfer performance of an electronic device. | FENG HuiJun CHEN LinGen XIE ZhiHui SUN FengRui | 2016 | Science China(Technological Sciences)2016，59，9： | 7 |
| 15 | Generalized constructal optimization of strip laminar cooling process based on entransy theory显示文摘A strip laminar cooling process is investigated in this paper. Entransy theory and generalized constructal optimization are introduced into the optimization. Total water flow amount(WFA) in the laminar cooling zone(LCZ) and complex function are taken as the constraint and optimization objective, respectively. The entransy dissipation(ED) and maximum temperature different(MTD) of the strip are simultaneously considered in the complex function. WFA distributions of the headers in the LCZ are optimized. The effects of the total WFA, strip thickness and cooling water temperature on the optimal results are analyzed.The optimal cooling scheme is the eleventh cooling mode for the considered total 257 cooling schemes, and the complex function,ED and MTD of the strip are decreased by 11.59%, 5.59% and 17.58% compared with the initial cooling scheme, respectively.The total WFA and strip thickness have the obvious influences on the optimal cooing scheme, but the cooling water temperature has no influence in the parameter analysis range of this paper. The 'generalized optimal construct' derived by minimum complex function shows a compromise between the energy retention and quality of the strip. | FENG HuiJun CHEN LinGen LIU Xiong XIE ZhiHui SUN FengRui | 2016 | Science China(Technological Sciences)2016，59，11： | 7 |
| 16 | Monte Carlo simulation based on Geant4 of single event upset induced by heavy ions显示文摘The present work is a computational simulation of single event upset(SEU) induced by heavy ions passing through the device with Geant4-tool based on Monte Carlo transport code.Key parameters affecting SEU occurrence are examined,and related geometrical construction and critical charge are quantified.The MUlti-Functional Package for SEU Analysis(MUFPSA) has been successfully programmed and applied for SEU occurrence after the completion of device geometrical construction,critical charge,and SEU cross section calculation.The proposed MUFPSA has yielded a good agreement with MRED.Specifically,the results show that higher LET incident ions lead to increased SEU vulnerability due to more diffusion and higher energy deposition.In addition,the analytical method of radial ionization profile provides a good complementary interpretation. | GENG Chao LIU Jie ZHANG ZhanGang HOU MingDong SUN YouMei XI Kai GU Song DUAN JingLai YAO HuiJun MO Dan LUO Jie | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，6： | 6 |
| 17 | Verification and Improvement of the Ability of CFSv2 to Predict the Antarctic Oscillation in Boreal Spring显示文摘The boreal spring Antarctic Oscillation(AAO) has a significant impact on the spring and summer climate in China. This study evaluates the capability of the NCEP's Climate Forecast System, version 2(CFSv2), in predicting the boreal spring AAO for the period 1983–2015. The results indicate that CFSv2 has poor skill in predicting the spring AAO, failing to predict the zonally symmetric spatial pattern of the AAO, with an insignificant correlation of 0.02 between the predicted and observed AAO Index(AAOI). Considering the interannual increment approach can amplify the prediction signals, we firstly establish a dynamical–statistical model to improve the interannual increment of the AAOI(DY AAOI), with two predictors of CFSv2-forecasted concurrent spring sea surface temperatures and observed preceding autumn sea ice. This dynamical–statistical model demonstrates good capability in predicting DY AAOI, with a significant correlation coefficient of 0.58 between the observation and prediction during 1983–2015 in the two-year-out cross-validation. Then, we obtain an improved AAOI by adding the improved DY AAOI to the preceding observed AAOI. The improved AAOI shows a significant correlation coefficient of 0.45 with the observed AAOI during 1983–2015. Moreover, the unrealistic atmospheric response to March–April–May sea ice in CFSv2 may be the possible cause for the failure of CFSv2 to predict the AAO. This study gives new clues regarding AAO prediction and short-term climate prediction. | Dapeng ZHANG Yanyan HUANG Bo SUN Fei LI Huijun WANG | 2019 | Advances in Atmospheric Sciences2019，36，3： | 6 |
| 18 | Cilastatin protects against imipenem-induced nephrotoxicity via inhibition of renal organic anion transporters(OATs)显示文摘Imipenem is a carbapenem antibiotic. However, Imipenem could not be marketed owing to its instability and nephrotoxicity until cilastatin, an inhibitor of renal dehydropeptidase-I(DHP-I),was developed. In present study, the potential roles of renal organic anion transporters(OATs) in alleviating the nephrotoxicity of imipenem by cilastatin were investigated in vitro and in rabbits. Our results indicated that imipenem and cilastatin were substrates of h OAT1 and h OAT3. Cilastatin inhibited h OAT1/3-mediated transport of imipenem with IC50 values comparable to the clinical concentration, suggesting the potential to cause a clinical drug–drug interaction(DDI). Moreover,imipenem exhibited h OAT1/3-dependent cytotoxicity, which was alleviated by cilastatin and probenecid. Furthermore, cilastatin and probenecid ameliorated imipenem-induced rabbit acute kidney injury, and reduced the renal secretion of imipenem. Cilastatin and probenecid inhibited intracellular accumulation of imipenem and sequentially decreased the nephrocyte toxicity in rabbit primary proximal tubule cells. Renal OATs, besides DHP-I, was also the target of interaction between imipenem and cilastatin, and contributed to the nephrotoxicity of imipenem. This therefore gives in part the explanation about the mechanism by which cilastatin protected against imipenem-induced nephrotoxicity. Thus, OATs can potentially be used as a therapeutic target to avoid the renal adverse reaction of imipenem in clinic. | Xiaokui Huo Qiang Meng Changyuan Wang Yanna Zhu Zhihao Liu Xiaodong Ma Xiaochi Ma Jinyong Peng Huijun Sun Kexin Liu | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 5 |
| 19 | LANDMARC Localization Algorithm Based on Weight Optimization显示文摘In order to solve the problem that the difference of Received signal strength(RSS) between tags will become large when tags are close to the reader, which exists in LANDMARC system, a LANDMARC localization algorithm based on weight optimization is proposed in the paper. We optimize the weight by redefining the formulas of in-weight and ex-weight. In-weight formula is discussed under the free space propagation model. The definition of ex-weight is obtained by analyzing the relationship between RSS and distance under the log-distance path loss model. We evaluate the performance of the proposed algorithm and compare it with the algorithm based on normalized weight. The simulation results show the superior performance of the proposed algorithm in terms of location accuracy. | HU Bing PENG Huijun SUN Zhixin | 2018 | Chinese Journal of Electronics2018，27，6： | 5 |
| 20 | The northern annular mode:More zonal symmetric than the southern annular mode显示文摘Fan (2007) recently documented the zonal asymmetry of the Antarctic oscillation (AAO) in the austral winter. In this research, the zonal asymmetry of the northern annular mode, or the Arctic oscillation (AO), in the interannual variability is studied for the boreal winter. It is shown that there is zonal asymmetry of the AO as well, similar to the case of the Antarctic oscillation (AAO). However, the zonal asymmetry of the AO is considerably weaker than that of the AAO. This is far beyond the speculation, since the zonal asymmetry of the geography is larger in the Northern Hemisphere than the Southern Hemisphere. The Western and Eastern Hemispheres portions of the AO are correlated at 0.54 for 1959― 1998, comparing with 0.23 for the case of the AAO. The authors also discussed the physical reason for this inter-hemispheric difference, and partly attributed it to the El Nio and Southern Oscillation (ENSO) cycle which may be represented by the SO index. It is indicated that the SO associated sea-level pressure (SLP) patterns are more zonal symmetric in the high latitudes of the Northern Hemisphere than the Southern Hemisphere. | WANG HuiJun SUN JianQi SU JingZhi | 2008 | Chinese Science Bulletin2008，53，11： | 5 |
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