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| 1 | Angular observation of joints of geckos moving on horizontal and vertical surfaces显示文摘Because of their outstanding climbing and motor coordination ability, geckos have provided the basis for a peculiar bionic model leading to the development of a geckorobot. A three-dimensional locomotion observation system was constructed to measure angular orientations of joints while geckos trotted (337.1 mm/s) and walked (66.7 mm/s) on horizontal surfaces, and trotted (241.5mm/s) and walked (30.6mm/s) on vertical surfaces. Moving over horizontal surfaces, the joints rotated more quickly the greater the speed, and the swinging scope of forelimbs stayed nearly at 59 degrees when swinging forward, but extended from 72 degrees to 79.2 degrees when swinging backward. The lifting angle of forelimbs was always positive to keep the center of mass close to the surface when moving up vertical surfaces, the scope of the forward swinging forelimbs forward extended from 33.7 degrees to 36.7 degrees with increasing speed, while the scope of backward swinging forelimbs remained almost the same at 87.5 degrees. Alternative gaits had little effect on the swing angle of hindlimbs of the geckos moving on both horizontal and vertical surfaces. | LI HongKai DAI ZhenDong SHI AiJu ZHANG Hao SUN JiuRong | 2009 | Chinese Science Bulletin2009，54，4： | 13 |
| 2 | Geographical Patterns of Chinese Ethnic Minority Population Composition and Ethnic Diversity显示文摘Ethnicity is a carrier of language and culture.Spatial distribution of ethnic diversity is fundamental for identifying and reconstructing the migration patterns and evolution histories of cultures and languages.Utilizing the Chinese 4th National Census (1990) data,we investigated the specific time geographical patterns of population and diversity of Chinese ethnicminorities.As anticipated,results show that Chineseminorities are chiefly concentrated in dis-tant plateaus and mountains in the southwest,northwest and northeast of China.Further,population density centers of the 10 majorminorities are rather scattered,alternatively dominating at different parts of the country.This study pro-vides a first comprehensive quantitative test on a prevailing notion of 'six plates and three corridors' on the empirical clustering patterns of Chinese ethnicminorities.There are more consistent evidences supporting this notion in the north of China,with the central and southern regions showing more complex patterns,potentially transformed by processes such as migration,fragmentation,and percolation.The results of this study suggest that a geographical ap-proach can provide heuristic and complementary information for better understanding of historical social processes. | SHEN Zehao LI Peng SUN Hongkai PANG Lihua | 2011 | Chinese Geographical Science2011，21，4： | 3 |
| 3 | Bract suppression regulated by the miR156/529-SPLs-NL1-PLA1 module is required for the transition from vegetative to reproductive branching in rice显示文摘Reproductive transition of grasses is characterized by switching the pattern of lateral branches,featuring the suppression of outgrowth of the subtending leaves(bracts)and rapid formation of higher-order branches in the inflorescence(panicle).However,the molecular mechanisms underlying such changes remain largely unknown.Here,we show that bract suppression is required for the reproductive branching in rice.We identified a pathway involving the intrinsic time ruler microRNAI56/529,their targets SQUAMOSA PROMOTER BINDING PROTEIN LIKE(SPL)genes,NECK LEAF1(NL1),and PLASTOCHRON1(PLA1),which regulates the bract outgrowth and thus affects the pattern switch between vegetative and reproductive branching.Suppression of the bract results in global reprogramming of transcriptome and chromatin accessibility following the reproductive transition,while these processes are largely dysregu-lated in the mutants of these genes.These discoveries contribute to our understanding of the dynamic plant architecture and provide novel insights for improving crop yields. | Lei Wang Luchang Ming Keyan Liao Chunjiao Xia Shengyuan Sun Yu Chang Hongkai Wang Debao Fu Conghao Xu Zhengji Wang Xu Li Weibo Xie Yidan Ouyang Qinglu Zhang Xianghua Li Qinghua Zhang Jinghua Xiao Qifa Zhang | 2021 | Molecular Plant2021，14，7： | 2 |
| 4 | Rate Control for Real-time Video Network Transmission on End-to-End Ratedistortion and Application-oriented QoS显示文摘 | Xiong Hongkai Sun Jun Yu Songyu | 2005 | IEEE Transactions on Broadcasting2005，51，1： | 1 |
| 5 | Progress on deuterated potassium dihydrogen phosphate(DKDP)crystals for high power laser system application显示文摘In this review,we introduce the progress in the growth of large-aperture DKDP crystals and some aspects of crystal quality including determination of deuterium content,homogeneity of deuterium distribution,residual strains,nonlinear absorption,and laser-induced damage resistance for its application in high power laser system.Large-aperture high-quality DKDP crystal with deuteration level of 70%has been successfully grown by the traditional method,which can fabricate the large single-crystal optics with the size exceeding 400 mm.Neutron diffraction technique is an efficient method to research the deuterium content and 3D residual strains in single crystals.More efforts have been paid in the processes of purity of raw materials,continuous filtration technology,thermal annealing and laser conditioning for increasing the laser-induced damage threshold(LIDT)and these processes enable the currently grown crystals to meet the specifications of the laser system for inertial confinement fusion(ICF),although the laser damage mechanism and laser conditioning mechanism are still not well understood.The advancements on growth of large-aperture high-quality DKDP crystal would support the development of ICF in China. | Mingxia Xu Baoan Liu Lisong Zhang Hongkai Ren Qingtian Gu Xun Sun Shenglai Wang Xinguang Xu | 2022 | Light(Science & Applications)2022，11，9： | 1 |
| 6 | Glucosamine, a naturally occurring amino monosaccharide, inhibits A549and H446 cell proliferation by blocking G1/S transition显示文摘 | Yinghua Ju Aiming Yu Xiuhua Sun Didi Wu Hongkai Zhang | 2013 | Molecular Medicine Reports2013，，3： | 1 |
| 7 | Design and Implementation of an End-to-End System for DTV Multicasting to Home Over Broadband IP Access Network显示文摘 | Luo Chuanfei Sun Jun Xiong Hongkai | 2005 | IEEE Transcations On Broadcasting2005，，9： | 1 |
| 8 | Analysis of epitopes in the capsid protein of avian hepatitis E virus by using monoclonal antibodies显示文摘 | Shiwei Dong Qin Zhao Mingzhe Lu Peiming Sun Hongkai Qiu Lu Zhang Junhua Lv En-Min Zhou | 2010 | Journal of Virological Methods2010，，2： | 1 |
| 9 | gudai qiangren he xiandai qiangyuzhi zuqun de guanxi(the Relation between the Ancient Qiang and Modern Ethnic Groups of Qiang Language Family)显示文摘 | Sun Hongkai | | 0，，01： | 1 |
| 10 | Integration of Brassinosteroid Signal Transduction with the Transcription Network for Plant Growth Regulation in Arabidopsis显示文摘 | Yu Sun Xi-Ying Fan Dong-Mei Cao Wenqiang Tang Kun He Jia-Ying Zhu Jun-Xian He Ming-Yi Bai Shengwei Zhu Eunkyoo Oh Sunita Patil Tae-Wuk Kim Hongkai Ji Wing Hong Wong Seung Y. Rhee Zhi-Yong Wang | 2010 | Developmental Cell2010，，5： | 1 |
| 11 | A Preliminary Study on the Vitality Ordering of Minority Languages in China显示文摘Ordering the minority languages in China in terms of their vitality can help decide what priorities are in securing the most endangered ethnic languages. In view of the actual condition of the Chinese ethnic languages, this paper proposes some corresponding comprehensive indexes and ranks over 100 ethnic languages of China in terms of their vitality. | Sun Hongkai | 2008 | 宏观语言学2008，2，1： | 0 |
| 12 | Common Innovations in Sino-Tibetan Languages显示文摘To establish a classification on the basis of genetic linguistics requires two indispensible conditions: common retention, including cognate lexical retention and cognate morphological retention, and common innovation in a language group. The first condition is primary, and is the motivation for classification and the evidence of a genetic relationship. The second condition is secondary and supportive, and is the feature,approach and sign of a language group. This article focuses on common innovations in the Sino-Tibetan language family. Tone, voiceless aspirated stops, affricates, classifiers, noun prefixes for kinship and overlap are six common innovations that are proposed for defining the Sino-Tibetan language family. | Sun Hongkai | 2016 | 宏观语言学2016，4，1： | 0 |
| 13 | Sodium butyrate activates HMGCS2 to promote ketone body production through SIRT5-mediated desuccinylation显示文摘Ketone bodies have beneficial metabolic activities,and the induction of plasma ketone bodies is a health promotion strategy.Dietary supplementation of sodium butyrate(SB)is an effective approach in the induction of plasma ketone bodies.However,the cellular and molecular mechanisms are unknown.In this study,SB was found to enhance the catalytic activity of 3-hydroxy-3-methylglutaryl-CoA synthase 2(HMGCS2),a rate-limiting enzyme in ketogenesis,to promote ketone body production in hepatocytes.SB administrated by gavage or intraperitoneal injection significantly induced bloodβ-hydroxybutyrate(BHB)in mice.BHB production was induced in the primary hepatocytes by SB.Protein succinylation was altered by SB in the liver tissues with down-regulation in 58 proteins and up-regulation in 26 proteins in the proteomics analysis.However,the alteration was mostly observed in mitochondrial proteins with 41%down-and 65%up-regulation,respectively.Succinylation status of HMGCS2 protein was altered by a reduction at two sites(K221 and K358)without a change in the protein level.The SB effect was significantly reduced by a SIRT5 inhibitor and in Sirt5-KO mice.The data suggests that SB activated HMGCS2 through SIRT5-mediated desuccinylation for ketone body production by the liver.The effect was not associated with an elevation in NAD+/NADH ratio according to our metabolomics analysis.The data provide a novel molecular mechanism for SB activity in the induction of ketone body production. | Yanhong Xu Xiaotong Ye Yang Zhou Xinyu Cao Shiqiao Peng Yue Peng Xiaoying Zhang Yili Sun Haowen Jiang Wenying Huang Hongkai Lian Jiajun Yang Jia Li Jianping Ye | 2023 | Frontiers of Medicine2023，17，2： | 0 |
| 14 | Construction and application of digital Chinese human atlases based on large medical image dataset显示文摘Digital human atlases are widely used in human simulation and medical applications.However,traditional carvada-based atlases cannot represent the statistical features of large living population.This study constructed digital Chinese human atlases based on large medical image dataset.Artificial intelligent methods were developed to segment 3D organ structures and learn inter-subject organ shape variations from the medical images collected across the country.A deformable human atlas was constructed with hundreds of adjustable anthropometry parameters to realize personalized modelling of body shape,facial feature and organ morphometry.Moreover,statistical physiological parameters of bone density,heart beating pattern and glucose metabolism were also extracted from multi-modality images of different ages and genders.This anatomy-function-combined atlas was already used in many applications including individualized human modelling,medical image diagnosis,surgery planning,human factor engineering,electromagnetic and thermodynamics simulation,patient communication,anatomy teaching,athlete training and industry standard establishment and has been productized by enterprises. | Wang Hongkai Sun Xiaobang Zhai Haoyu Zhuang Mingrui | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 15 | PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism显示文摘Metabolic reprogramming is a hallmark of cancer,including lung cancer.However,the exact underlying mechanism and therapeutic potential are largely unknown.Here we report that protein arginine methyltransferase 6(PRMT6)is highly expressed in lung cancer and is required for cell metabolism,tumorigenicity,and cisplatin response of lung cancer.PRMT6 regulated the oxidative pentose phosphate pathway(PPP)flux and glycolysis pathway in human lung cancer by increasing the activity of 6-phosphogluconate dehydrogenase(6PGD)and a-enolase(ENO1).Furthermore,PRMT6 methylated R324 of 6PGD to enhancing its activity;while methylation at R9 and R372 of ENO1 promotes formation of active ENO1 dimers and 2-phosphoglycerate(2-PG)binding to ENO1,respectively.Lastly,targeting PRMT6 blocked the oxidative PPP flux,glycolysis pathway,and tumor growth,as well as enhanced the antitumor effects of cisplatin in lung cancer.Together,this study demonstrates that PRMT6 acts as a posttranslational modification(PTM)regulator of glucose metabolism,which leads to the pathogenesis of lung cancer.It was proven that the PRMT6-6PGD/ENO1 regulatory axis is an important determinant of carcinogenesis and may become a promising cancer therapeutic strategy. | Mingming Sun Leilei Li Yujia Niu Yingzhi Wang Qi Yan Fei Xie Yaya Qiao Jiaqi Song Huanran Sun Zhen Li Sizhen Lai Hongkai Chang Han Zhang Jiyan Wang Chenxin Yang Huifang Zhao Junzhen Tan Yanping Li Shuangping Liu Bin Lu Min Liu Guangyao Kong Yujun Zhao Chunze Zhang Shu-Hai Lin Cheng Luo Shuai Zhang Changliang Shan | 2023 | Acta Pharmaceutica Sinica B2023，13，1： | 0 |
| 16 | All-perfluoropolymer,nonlinear stability-assisted monolithic surface combines topology-specific superwettability with ultradurability显示文摘Developing versatile and robust surfaces that mimic the skins of living beings to regulate air/liquid/solid matter is critical for many bioinspired applications.Despite notable achievements,such as in the case of developing robust superhydrophobic surfaces,it remains elusive to realize simultaneously topology-specific superwettability and multipronged durability owing to their inherent tradeoff and the lack of a scalable fabrication method.Here,we present a largely unexplored strategy of preparing an all-perfluoropolymer(Teflon),nonlinear stability-assisted monolithic surface for efficient regulating matters. | Wanbo Li Chiu-wing Chan Zeyu Li Sin-Yung Siu Siyu Chen Han Sun Zeyu Liu Yisu Wang Chong Hu Nicola Maria Pugno Richard N.Zare Hongkai Wu Kangning Ren | 2023 | The Innovation2023，4，2： | 0 |
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