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| 1 | Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation显示文摘Genome-wide association studies(GWASs) have been instrumental in understanding complex phenotypic traits. However, they have rarely been used to understand lineage-specific pathways and functions that contribute to the trait. In this study, by integrating lineage-specific enhancers from mesenchymal and myeloid compartments with bone mineral density loci, we were able to segregate osteoblast-and osteoclast(OC)-specific functions. Specifically, in OCs, a PU.1-dependent transcription factor(TF)network was revealed. Deletion of PU.1 in OCs in mice resulted in severe osteopetrosis. Functional genomic analysis indicated PU.1 and MITF orchestrated a TF network essential for OC differentiation. Several of these TFs were regulated by cooperative binding of PU.1 with BRD4 to form superenhancers. Further, PU.1 is essential for conformational changes in the superenhancer region of Nfatc1. In summary, our study demonstrates that combining GWASs with genome-wide binding studies and model organisms could decipher lineage-specific pathways contributing to complex disease states. | Heather A.Carey Blake E.Hildreth III Jennifer A.Geisler Mara C.Nickel Jennifer Cabrera Sankha Ghosh Yue Jiang Jing Yan James Lee Sandeep Makam Nicholas A.Young Giancarlo R.Valiente Wael N.Jarjour Kun Huang Thomas J.Rosol Ramiro E.Toribio Julia F.Charles Michael C.Ostrowski Sudarshana M.Sharma | 2018 | Bone Research2018，6，1： | 4 |
| 2 | Enzymatic liquefaction of some vatitties of mango pulp显示文摘 | Sreenath H K Sudarshana K R Sudarshana Krishana | 1995 | Food science technology1995，28，2： | 1 |
| 3 | Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress显示文摘 | Sudarshana Purkayasthaa Hai Zhanga Guo Zhanga | 2011 | Proceedings of the National Academy of Sciences of United States of Americ2011，108，7： | 1 |
| 4 | In vitro multiple shoot induction from excised shoot tips and nodal segment explants of- Lagerstroemia indica(L)-A medicinal cum Ornamental Shrub显示文摘 | Niranjan M H Sudarshana M S Girisha S T | | Journal of Biomedical Sciences and Researched 20，2，3： | 1 |
| 5 | Novel PCR primers for detection of genetically diverse virulent Agrobacterium tumefaciens biovar 1 strains显示文摘 | Lani Yakabe M. Maccree Padma Sudarshana Ali McClean Shane Parker William Wechter Gernot Presting Mizuri Marutani-Hert Daniel Kluepfel | 2012 | Journal of General Plant Pathology2012，，2： | 1 |
| 6 | Lysozyme separation by hollow-fibre ultrafiltration显示文摘 | Raja Ghosh Saliya Sudarshana Silval Zhanfeng Cui | 2000 | Biochem Biotecnol2000，8，： | 1 |
| 7 | Serological relationship and purification of bud necrosis virus,a tospovirus occurring in peanut (Arachis hypogaea) in India显示文摘 | Reddy D V R Ratna A S Sudarshana M R | 1992 | Ann Appl Biol1992，120，： | 1 |
| 8 | Complete genome sequence of a novel vitivirus isolated from grapevine 显示文摘 | Rwahnih M A Sudarshana M R Uyemoto J K | 2012 | Journal of virology2012，86，17： | 1 |
| 9 | Free Cholesterol Accumulation in Macrophage Membranes Activates Toll-Like Receptors and p38 Mitogen-Activated Protein Kinase and Induces Cathepsin K显示文摘 | Yu Sun Minako Ishibashi Tracie Seimon Mingsum Lee Sudarshana M. Sharma Katherine A. Fitzgerald Andriy O. Samokhin Yibin Wang Scott Sayers Masanori Aikawa W Gray Jerome Michael C. Ostrowski Dieter Bromme Peter Libby Ira A. Tabas Carrie L. Welch Alan R. Tal | 2009 | Circulation Research2009，，4： | 1 |
| 10 | Neural dysregulation of peripheral insulin action and bloodpressure by brain endoplasmic reticulum stress 显示文摘 | Sudarshana Purkayasthaa Hai Zhanga Guo Zhanga | 2011 | Proceedings of the National Academy of Sciences of UnitedStates ofAmeric2011，108，7： | 1 |
| 11 | Dietary fiber content of commonly fresh and cooked vegetables consumed in India显示文摘 | Farhath Khanum Siddalinga Swamy M Sudarshana Krishna K R Santhanam K Viswanathan K R | 2000 | Plant Foods for Human Nutrition2000，55，3： | 1 |
| 12 | Curcumin blocks brain tumor formation显示文摘 | Sudarshana Purkayastha Alexandra Berliner Suraj Shawn Fernando | | 0，，： | 1 |
| 13 | Antimicrobial activity of Rauvolfia tetraphyUa and Physalis minima leaf and callus extracts 显示文摘 | Shariff N Sudarshana MS Umesha S | 2006 | Afr J Biotecbnol2006，5，10： | 1 |
| 14 | Rain rate and rain attenuation estimation for Ku band satellite communications over Sri Lanks显示文摘 | SUDARSHANA K P S SAMARASINGHE A T L K | | 0，，： | 1 |
| 15 | Bean golden yellow mosaic virus from Chiapas,Mexico:Characterization,pseudorecombination with other bean-infecting geminiviruses and germ plasm screening显示文摘 | GARRIDO-RAMIREZ E R SUDARSHANA M R GILBERTSON R L | 2000 | Phytopathology2000，90，： | 1 |
| 16 | Detection of Grapevine leafroll-associated virus 7 using real time qRT-PCR and conventional RT-PCR显示文摘 | Maher Al Rwahnih Fatima Osman Mysore Sudarshana Jerry Uyemoto Angelantonio Minafra Pasquale Saldarelli Giovanni Martelli Adib Rowhani | 2011 | Journal of Virological Methods2011，，2： | 1 |
| 17 | Serological relationship and purification of bud necrosis virus,a tospovirus occurring in peanut 显示文摘 | Reddy D V R Ratna A S Sudarshana M R | 1992 | Annual of Applied Biology1992，120，： | 1 |
| 18 | Serological relationship and purification of bud necrosis virus, a tospovirus occurring in peanut 显示文摘 | Reddy D V R Ratna A S Sudarshana M R | 1992 | Annals of Applied Biology1992，120，： | 1 |
| 19 | Detary fiber content of commonly fresh and cooked vegetables consumed in India显示文摘 | Siddalinga S Sudarshana K R | 2000 | Plant Foods for Human Nutrition2000，55，： | 1 |
| 20 | Effect of Parental Growth on Dynamics of Conjugative Plasmid Transfer in the Pea Spermosphere显示文摘 | Sudarshana P Knudsen G R | 1995 | Appl Environ Microbiol1995，61，8： | 1 |
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