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| 1 | CNS-PNETS分子分类中出现新的脑肿瘤实体类型显示文摘中枢神经系统原始神经外胚层肿瘤(CNS—PNET)是具有高度侵袭性分化差的胚胎性肿瘤,主要好发于幼儿,也可见于青少年和成人。 | Sturm D Orr B A Toprak U H 李晓玲 王行富 | 2016 | 临床与实验病理学杂志2016，32，7： | 16 |
| 2 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 3 | Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma 显示文摘 | Sturm D Witt H Hovestadt V | 2012 | Cancer Cell2012，22，4： | 1 |
| 4 | Flame retardancy mechanisms of metal phosphinates and metal phosphinates in combination with melamine cyanurate in glass-fiber reinforced poly (1,4-butylene terephtalate):The influence of metal cation显示文摘 | BRAUN U BAHR H STURM H | 2008 | Polym Adv Technol2008，19，6： | 1 |
| 5 | External coupling efficiency in planar organic light-emitting devices显示文摘 | Lu M H Sturm J C | 2001 | Appl Phys Lett2001，78，： | 1 |
| 6 | Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcrip- tion via a negative FXR response element 显示文摘 | Claudel T Sturm E Duez H | 2002 | J Clin Invest2002，109，： | 1 |
| 7 | Bile acid-activated nuclear receptor FXR suppresses apolipoprotein AI transcription via a negative FXR response element显示文摘 | Claudel T Sturm E Duez H Torra IP Sirvent A Kosykh V | | 0，，： | 1 |
| 8 | Analysis of cucurbitacins in medicinal plants by high-pressure liquid chromatography-mass spectrometry 显示文摘 | Sturm S Stuppner H | 2000 | Phytochem Anal2000，11，2： | 1 |
| 9 | Natural (^210Pb, ^7Be) and fallout (^137Cs,^239,240pu,^9OSr) radionuclides as geochemical tracers of sedimentation in Greifensee, Switzerland 显示文摘 | Wan G J Santsehi P H Sturm M Farrenkothen K Lueck A Werth W Schuler Ch | 1987 | Chem Geol1987，63，34： | 1 |
| 10 | Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma 显示文摘 | Sturm D Witt H Hovestadt V | 2012 | Cancer Ce112012，22，4： | 1 |
| 11 | Conbined p53/Bax mutation results in extremely poor prognosis in gastric carcinoma with low microsatellite instability显示文摘 | Mrozek A Petrowsky H Sturm I el al | 2003 | Cell Death Differ2003，10，4： | 1 |
| 12 | Structure formation on the surface of indium phosphide irradiated by femtosecond laser pulses显示文摘 | Bonse J Munz M Sturm H | 2005 | Journal of Applied Physics2005，97，01： | 1 |
| 13 | Management of heart failure in The Netherlands 显示文摘 | Jaarsma T Hasijer-Ruskalnp FM Sturm H | 2005 | Eur J Heart Fail2005，7，： | 1 |
| 14 | Fusions of Description Logics and Abstract Description Systems显示文摘 | Baader F Lutz C Sturm H | 2003 | Journal of Artificial Intelligence Research2003，16，2： | 1 |
| 15 | The ecology of algal biodiesel produc- tion显示文摘 | VAI H SMITH BELINDA S M STURM FRANK J DE- NOYELLES | 2009 | Trends in Ecology and Evolution2009，25，5： | 1 |
| 16 | Riskanalysiy of linearaccelerator radiosurgery显示文摘 | Treuer H Sturm V | 1996 | Int J Ra diat Oncol Biolphys1996，36，5： | 1 |
| 17 | Compounds structural- ly related to ellagie acid show improved antiplasmodial activity 显示文摘 | Sturm N Hu Y Zimmermann H | 2009 | Antimicrob Agents Ch2009，53，2： | 1 |
| 18 | Combined p53/Bax mutation results in extremely poor prognosis in gastric carcinoma with low microsatellite instability 显示文摘 | Mrozek A Petrowsky H Sturm I | 2003 | Cell Death Differ2003，10，4： | 1 |
| 19 | Dynamic expression profile of p21 WAF1/CIP1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy显示文摘 | Sturm I Lage H | 2003 | J Clin Oncol2003，21，18： | 1 |
| 20 | Purification and characterization of neutral and alkaline invertase from carrot显示文摘 | Lee H S Sturm A | 1996 | Plant Physiol1996，112，： | 1 |
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