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36篇 您的检索式：作者名="STOLZ V"

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	题名	作者	年代	出处	被引量
1	Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing显示文摘Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis,a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5(Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by si RNA, genetic deletion using the Cre-lox P system, or inhibition with the small molecule roscovitine enhanced osteoblastogenesis in vitro. Roscovitine treatment significantly enhanced bone mass by increasing osteoblastogenesis and improved fracture healing in mice. Mechanistically, downregulation of Cdk5 expression increased Erk phosphorylation, resulting in enhanced osteoblast-specific gene expression. Notably, simultaneous Cdk5 and Erk depletion abrogated the osteoblastogenesis conferred by Cdk5 depletion alone, suggesting that Cdk5 regulates osteoblast differentiation through MAPK pathway modulation. We conclude that Cdk5 is a potential therapeutic target to treat osteoporosis and improve fracture healing.	Mubashir Ahmad Benjamin Thilo Krüger Torsten Kroll Sabine Vettorazzi Ann-Kristin Dorn Florian Mengele Sooyeon Lee Sayantan Nandi Dilay Yilmaz Miriam Stolz Naveen Kumar Tangudu David Carro Vázquez Johanna Pachmayr Ion Cristian Cirstea Maja Vujic Spasic Aspasia Ploubidou Anita Ignatius Jan Tuckermann	2022	Bone Research2022，10，3：	2
2	Purification and characterization of the enantioselective nitrile hydratase from Rhodococcus equiA4 显示文摘	Prepachalova I Martinkova L Stolz A Ovesna M Bezouska K Kopecky J Kren V	2001	Appl Microbiol Bioteehnol2001，55，：	1
3	Determining mental state from EEG signals using neural networks显示文摘	ANDERSON C W DEVULAPALLI S V STOLZ E A	1995	Sci Program1995，4，3：	1
4	Magnetic full-tensor SQUID gradiometer system for geophysical applications 显示文摘	Stolz R Zakosarenko V Schulz M	2006	The Leading Edge2006，，：	1
5	Exciton-phonon coupling in indirect gap AgBr nanocrystals显示文摘	Vogelsang H Stolz H Osten W V	1996	J Lumin1996，70，16：	1
6	Temporal assertions using AspectJ显示文摘	Stolz V Bodden E	2006	Elec- tronic Notes in Theoretical Computer Science2006，144，4：	1
7	Magneticfull- tensor SQUID gradiometer system for geophysical appli- cations 显示文摘	Stolz R Zakosarenko V Schulz M	2006	Leading Edge2006，25，2：	1
8	Temporal assertions using aspectJ 显示文摘	STOLZ V BODDEN E	2006	Electronic Notes in Theoretical Computer Science2006，144，4：	1
9	Robustness testing for software components显示文摘	Lei B Li X Liu Z Mofisset C Stolz V		0，，10：	1
10	Magnetic full-tensor SQUID gradiometer system for geophysical applications显示文摘	Stolz R Zakosarenko V Schulz M		0，，：	1
11	Magnetic full-tensor SQUID gradiometer system for geophysical applications显示文摘	Stolz R Zakosarenko V Schulz M	2006	TLE2006，25，2：	1
12	Magnetic Full Tensor SQUID Gradiometer System for Geophysical Applications 显示文摘	Stolz R Zakosarenko V Schulz M	2012	The Leading Edge2012，，2：	1
13	Laser intensification by spherical inclusions embedded within multilayer coatings 显示文摘	Stolz C J Feit M D Pistor T V	2006	Applied Optlcs2006，45，7：	1
14	Magnetic full-tensor SQUID gradiometer system for geophysi- cal applications 显示文摘	Stolz R Zakosarenko V Sehulz M	2006	Leading Edge (Tulsa OK)2006，25，2：	1
15	Muhichip vertical-externalcavity surface-emitting lasers:a coherent power scaling scheme显示文摘	Fan L Fallahi M Hader J Zakharian A R Moloney J V Murray J T Bedford R Stolz W Koch S W		0，，24：	1
16	Extended tunability in a two-chip VECSEL显示文摘	Fan L Fallahi M Zakharian A Hader J Moloney J V Bedford R Murray J T Stolz W Koch S W		0，，08：	1
17	5-W yellow laser by intracavity frequency doubling of high-power verticalexternal-cavity surface-emitting laser显示文摘	Fallahi M Fan L Kaneda Y Hessenius C Hader J Li H Moloney J V Kunert B Stolz W Koch S W Murray J Bedford R		0，，20：	1
18	Tunable high-power high-brightness linearly polarized vertical-external-cavity surfaceemitting lasers显示文摘	Fan L Fallahi M Murray J T Bedford R Kaneda Y Zakharian A R Hader J Moloney J V Stolz W Koch S W		0，，02：	1
19	A Stochastic Approach to the Grammatical Coding of English显示文摘	Stolz W S Tannenbaum PH Carstensen F V	1965	Communications of the ACM1965，8，6：	1
20	Laser intensification by spherical inclusions embedded within multilayer coatings显示文摘	Stolz C J Feit M D Pistor T V	2006	Appl Opt2006，45，7：	1

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