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| 1 | The roles of MAPKs in disease显示文摘印射响应许多 ligands 和房间刺激涉及大量的细胞的小径和功能的家族 ases transduce 信号。MAPK 的异常或不恰当的功能现在在从癌症到煽动性的疾病到肥胖和糖尿病的疾病被识别了。在许多房间类型, MAPK ERK1/2 被连接到细胞增殖。因为在地岬和 B-Raf 的变化,能激活 ERK1/2 串联,在许多人的肿瘤被发现, ERK1/2 被认为在一些癌症起一个作用。发信号的反常 ERK1/2 也在 polycystic 肾疾病被发现了,并且象 cardio-facio-cutaneous 症候群那样的严肃的发展混乱在 ERK1/2 串联的部件从变化产生。ERK1/2 在区分得好的房间是必要的并且在神经原并且在上皮的极性的维护被连接了到长期的 potentiation。另外, ERK1/2 为在胰腺的贝它房间的胰岛素基因抄写是重要的,它响应传播葡萄糖的增加生产胰岛素在有机体允许有效葡萄糖利用和存储。导致或镇压的营养素和荷尔蒙胰岛素分泌物以在贝它房间上反映能分泌的需求的一种方式激活或禁止 ERK1/2。在这和另外的规章的小径的骚乱可以导致对某些人的混乱的病原学的 ERK1/2 的贡献。 | Michael C Lawrence Arif Jivan Chunli Shao Lingling Duan Daryl Goad Elma Zaganjor Jihan Osborne Kathleen McGlynn Steve Stippec Svetlana Earnest Wei Chen Melanie H Cobb | 2008 | Cell Research2008，18，4： | 64 |
| 2 | Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart显示文摘出生后的心通过 hypertrophic 生长适应应力和超载,可能病理学或有益的一个过程(生理的肥大) 。生理的肥大改进心脏的性能在健康并且 diseased 个人,然而,宣传这有利改编的机制仍然保持糟糕定义。我们识别 cytokine cardiotrophin (CT1 ) 1 作为能够包括导致的导出 cardiomyocyte 的 angiogenic 信号的心肌层,和刺激的短暂、可逆的肥大概括心的生理的生长的特色的一个因素增加了由脉管形成。CT1 的能力从 caspase 激活的调停 CK2 的制止发源导致生理的肥大,阻止到无限制的病理学的生长的转变。外长的 CT1 蛋白质交货稀释了病理并且在正确的心失败的一个严格的模型恢复了可收缩的功能,建议为这难处理的心脏病的一种新奇处理选择。 | Mohammad Abdul-Ghani Colin Suen Baohua Jiang Yupu Deng Jonathan J Weldrick Charis Putinski Steve Brunette Pasan Femando Tom T Lee Peter Flynn Frans H H Leenen Patrick G Burgon Duncan J Stewar Lynn A Megeney | 2017 | Cell Research2017，27，10： | 8 |
| 3 | 折叠式结石拦截器在经皮肾镜取石术中的应用显示文摘目的探讨折叠式结石拦截器在经皮肾镜取石术(PCNL)治疗’肾结石中的有效性和安全性。方法回顾分析108例行PCNL肾结石患者临床资料。术中应用折叠式结石拦截器56例,未应用52例。2组患者性别、年龄、结石大小比较差异均无统计学意义(P〉0.05)。比较2组在结石清除率、手术时间、术中出血量、住院天数和并发症等差异。结果2组结石清除率分别为94.6%(53/56)和82.7%(43/52),手术时间分别为112、142min,出血量为205、245ml,差异均有统计学意义(P〈0.05)。2组住院时间分别为2.8、3.0d,并发症发生率分别为16.1%(9/56)和15.4%(8/52),2组比较差异无统计学意义(P〉0.05)。结论折叠式结石拦截器使用简单、方便、安全,PCNI。术中能有效阻止结石碎片下滑进入输尿管,提高结石清除率、缩短手术时间、减少手术出血量、不增加手术并发症。 | 陆鸿海 李爱华 Demetrius H Bagley Steve Dong | 2011 | 中华泌尿外科杂志2011，32，1： | 7 |
| 4 | 运用卫星数据和来自国家森林清查的野外数据进行全国森林变量估计显示文摘瑞典约有55%的土地面积被森林所覆盖。目前,瑞典的森林覆盖没有统一的和地理学上明晰的描述。现存的独立性数据源是Landsat TM和SPOT HRV卫星数据、地图蒙片(map mask)和森林清查样地。它们在一起,使森林变量(如材积和林分年龄)的计算机估计成为可能。这些估计的精确度在像素水平上是低的,但在林分水平上较高。在规划木材资源应如何加以利用或出于监测目的时,这类基于栅格的森林数据对政府来说是有帮助的。本文描述了以有效成本建立森林变量估计全国数据库的生成流程。我们在林分水平上评价了瑞典西南部某地森林变量估计的精确度。结果表明,总材积估计的整体均方根误差为33%,年龄估计的整体均方根误差为23%。 | Heather Reese Mats Nilsson Tina Granqvist Pahlén Olle Hagner Steve Joyce Ulf Tingelf Mikael Egberth Hkan Olsson 王胜 | 2003 | AMBIO-人类环境杂志2003，32，8： | 4 |
| 5 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 6 | Comparison of magnetic resonance and endoscopic retrograde cholangiopancreatography in malignant pancreaficobiliary obstruction显示文摘 | STEVE K LAWRENCE H WILLIAM R el al | 1999 | Arch Surg1999，134，： | 1 |
| 7 | Analysis of wax hydrocarbons in petroleum source rocks from the Damintun depression, eastern China,using high temperature gas chromatography 显示文摘 | Huang H P Steve R L Gordon D L | 2003 | Organic Geochemistry2003，34，： | 1 |
| 8 | Medical Therapy for Pulmonary Arteri- al Hypertension: updated ACCP evidence-based clinical practice guidelines 显示文摘 | David B Steve H Gregory S | 2004 | Chest2004，126，17： | 1 |
| 9 | LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator显示文摘 | Davide N Mauri Reinhard Ebner Rebecca I Montgomery Kristine D Kochel Timothy C Cheung Guo-Liang Yu Steve Ruben Marianne Murphy Roselyn J Eisenberg Gary H Cohen Patricia G Spear Carl F Ware | 1998 | Immunity1998，，： | 1 |
| 10 | Individual and relative fecundity of Black Crappie( Pomoxis nigromaculatus ) in Baldwin Cooling Pond 显示文摘 | Steve C B Roy C H | 1994 | Transaction of the Illinois State Academy of Science1994，87，3： | 1 |
| 11 | Cognitive therapy for bipolar illness-a pilot study of relapse prevention显示文摘 | Dominic H Bright J Steve J | 2000 | Cognitive Therapy and Research2000，24，5： | 1 |
| 12 | Antimicrobial-resistance of Streptococcus pneumoniae Isolated from the Lebanese Environment显示文摘 | Steve H Hadi Y Mutasem E | 2006 | Marine Environmental Research2006，62，： | 1 |
| 13 | Verification of the acute physiology and chronic health evaluation scoring system in a Hong Kong intensive care unit显示文摘 | Teike OH Robert H Steve S | 1993 | Crit Care Med1993，21，5： | 1 |
| 14 | Effect of temperature and relative humidity on the stability of infectious porcine reproductive and respiratory syndrome virus in aerosols显示文摘 | Joseph H Steve H Claudia MZ | 2007 | Vet Res2007，38，1： | 1 |
| 15 | Isolates of Staphylococcus aureus and saprophyticus Resistant to Antimicrobials Isolated from the Lebanese Aquatic Environment显示文摘 | Steve H Hadi Y Shady H | 2006 | Marine Pollution Bulletin2006，52，： | 1 |
| 16 | Power amplifiers and transmitters for RF and microwave 显示文摘 | Frederick H Raab peter asbeck steve cripps | 2002 | IEEE transactions on microwave theory and techniques( S0018 - 9480)2002，50，3： | 1 |
| 17 | Microwave Digestion Procedures for Environmental Matrices显示文摘 | Kathryn J L Steve J H | | 0，，07： | 1 |
| 18 | Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice显示文摘 | Ronaldo A Ribeiro Mariana L Vale Sara M Thomazzi Adriana B.P Paschoalato Steve Poole Sergio H Ferreira Fernando Q Cunha | 2000 | European Journal of Pharmacology2000，，1： | 1 |
| 19 | Microwave assisted polyol method for the preparation of Pt/C, Ru/C and PtRu/C nanoparticles and its application in electrooxidation of methanol显示文摘 | SRINIVASAN H STEVE B CHRISTOPHE C | 2012 | Journal of Power Sources2012，214，： | 1 |
| 20 | Inhibition of antibiotic efflux in bacteria by the novel muhidrug resistance inhibitors biricodar ( VX- 710) and timcodar(VX-853) 显示文摘 | STEVE M NAGRAJ M TRUDY H | 2004 | Antimicro Agents Chemother2004，48，11： | 1 |
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