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| 1 | National trends in resection of the distal pancreas显示文摘AIM:To investigate national trends in distal pancreatectomy(DP) through query of three national patient care databases.METHODS:From the Nationwide Inpatient Sample(NIS,2003-2009),the National Surgical Quality Improvement Project(NSQIP,2005-2010),and the Surveillance Epidemiology and End Results(SEER,2003-2009) databases using appropriate diagnostic and procedural codes we identified all patients with a diagnosis of a benign or malignant lesion of the body and/or tail of the pancreas that had undergone a partial or distal pancreatectomy.Utilization of laparoscopy was defined in NIS by the International Classification of Diseases,Ninth Revision correspondent procedure code;and in NSQIP by the exploratory laparoscopy or unlisted procedure current procedural terminology codes.In SEER,patients were identified by the International Classification of Diseases for Oncology,Third Edition diagnosis codes and the SEER Program Code Manual,third edition procedure codes.We analyzed the databases with respect to trends of inpatient outcome metrics,oncologic outcomes,and hospital volumes in patients with lesions of the neck and body of the pancreas that underwent operative resection.RESULTS:NIS,NSQIP and SEER identified 4242,2681 and 11 082 DP resections,respectively.Overall,laparoscopy was utilized in 15%(NIS) and 27%(NSQIP).No significant increase was seen over the course of the study.Resection was performed for malignancy in 59%(NIS) and 66%(NSQIP).Neither patient Body mass index nor comorbidities were associated with operative approach(P = 0.95 and P = 0.96,respectively).Mortality(3% vs 2%,P = 0.05) and reoperation(4% vs 4%,P = 1.0) was not different between laparoscopy and open groups.Overall complications(10% vs 15%,P < 0.001),hospital costs [44 741 dollars,interquartile range(IQR) 28 347-74 114 dollars vs 49 792 dollars,IQR 13 299-73 463,P = 0.02] and hospital length of stay(7 d,IQR 4-11 d vs 7 d,IQR 6-10,P < 0.001) were less when laparoscopy was utilized.One and two year survival after resection for malignancy were unchanged over the course of the study(ductal adenocarinoma 1-year 63.6% and 2-year 35.1%,P = 0.53;intraductal papillary mucinous neoplasm and nueroendocrine 1-year 90% and 2-year 84%,P = 0.25).The majority of resections were performed in teaching hospitals(77% NIS and 85% NSQIP),but minimally invasive surgery(MIS) was not more likely to be used in teaching hospitals(15% vs 14%,P = 0.26).Hospitals in the top decile for volume were more likely to be teaching hospitals than lower volume deciles(88% vs 43%,P < 0.001),but were no more likely to utilize MIS at resection.Complication rate in teaching and the top decile hospitals was not significantly decreased when compared to non-teaching(15% vs 14%,P = 0.72) and lower volume hospitals(14% vs 15%,P = 0.99).No difference was seen in the median number of lymph nodes and lymph node ratio in N1 disease when compared by year(P = 0.17 and P = 0.96,respectively).CONCLUSION:There appears to be an overall underutilization of laparoscopy for DP.Centralization does not appear to be occurring.Survival and lymph node harvest have not changed. | Armando Rosales-Velderrain Steven P Bowers Ross F Goldberg Tatyan M Clarke Mauricia A Buchanan John A Stauffer Horacio J Asbun | 2012 | World Journal of Gastroenterology2012，18，32： | 8 |
| 2 | Effect of hysteresis on water flow in a sand column with a fluctuating capillary fringe显示文摘 | Lehmann P Stauffer F Hinz C | 1998 | Journal of Contaminant Hydrology1998，33，： | 1 |
| 3 | Imidazo 显示文摘 | Stauffer F Maira SM Furet P | 2008 | Bioorg Med Cbem Lett2008，18，3： | 1 |
| 4 | Estimation of the evapotranspiration rate from diurnal groundwater level fluctua tions in the Okavango Delta, Botswana显示文摘 | Bauer P Thabeng G Stauffer F | 2004 | Journal of Hydrology2004，288，： | 1 |
| 5 | Thermal dose fractionation affects tumour physiological response显示文摘 | THRALL D E MACCARINI P STAUFFER P | 2012 | Int J Hyperthermia2012，28，： | 1 |
| 6 | One-step 3D shaping using a gray-tone mask for optical and microelectronic applications 显示文摘 | Oppliger Y Sixt P Stauffer J M etal | 1994 | Microelectronic Engineering1994，23，： | 1 |
| 7 | Feasibility of pancreatectomy following high-dose proton therapy for unresectable pancreatic cancer显示文摘AIM To review surgical outcomes for patients undergoing pancreatectomy after proton therapy with concomitant capecitabine for initially unresectable pancreatic adenocarcinoma.METHODS From April 2010 to September 2013,15 patients with initially unresectable pancreatic cancer were treated withproton therapy with concomitant capecitabine at 1000 mg orally twice daily. All patients received 59.40 Gy(RBE) to the gross disease and 1 patient received 50.40 Gy(RBE) to high-risk nodal targets. There were no treatment interruptions and no chemotherapy dose reductions. Six patients achieved a radiographic response sufficient to justify surgical exploration,of whom 1 was identified as having intraperitoneal dissemination at the time of surgery and the planned pancreatectomy was aborted. Five patients underwent resection. Procedures included:Laparoscopic standard pancreaticoduodenectomy(n = 3),open pyloris-sparing pancreaticoduodenectomy(n = 1),and open distal pancreatectomy with irreversible electroporation(IRE) of a pancreatic head mass(n = 1). RESULTS The median patient age was 60 years(range,51-67). The median duration of surgery was 419 min(range,290-484),with a median estimated blood loss of 850 cm^3(range,300-2000),median ICU stay of 1 d(range,0-2),and median hospital stay of 10 d(range,5-14). Three patients were re-admitted to a hospital within 30 d after discharge for wound infection(n = 1),delayed gastric emptying(n = 1),and ischemic gastritis(n = 1). Two patients underwent R0 resections and demonstrated minimal residual disease in the final pathology specimen. One patient,after negative pancreatic head biopsies,underwent IRE followed by distal pancreatectomy with no tumor seen in the specimen. Two patients underwent R2 resections. Only 1 patient demonstrated ultimate local progression at the primary site. Median survival for the 5 resected patients was 24 mo(range,10-30).CONCLUSION Pancreatic resection for patients with initially unresectable cancers is feasible after high-dose [59.4 Gy(RBE)] proton radiotherapy with a high rate of local control,acceptable surgical morbidity,and a median survival of 24 mo. | Kathryn E Hitchcock R Charles Nichols Christopher G Morris Debashish Bose Steven J Hughes John A Stauffer Scott A Celinski Elizabeth A Johnson Robert A Zaiden Nancy P Mendenhall Michael S Rutenberg | 2017 | World Journal of Gastrointestinal Surgery2017，9，4： | 1 |
| 8 | New aro- matase inhibitors from the 3-pyridyl arylether and l-aryl pyrrolo pyridine series显示文摘 | STAUFFER F FURET P FLOERSHEIMER A | 2012 | Bioorg Med Chem Lett2012，22，5： | 1 |
| 9 | Complex peptidyl nucleoside antibiotics:efficient syntheses of the glycosyl nucleoside amino acid cores显示文摘 | Bhaket P Stauffer C S Datta A | | 0，，25： | 1 |
| 10 | Non-invasive temperature profile estimation in a lossy medium based on multi-band radiometric signals sensed by a microwave dual-purpose body-contacting antenna显示文摘 | JACOBSEN S STAUFFER P | 2002 | International journal of hyperthermia2002，18，2： | 1 |
| 11 | The fate and significance of dead eggs of Schistosoma mansoni in the intestinal wall of the mouse显示文摘 | Lambert CR Striebel H Stauffer P | 1966 | Acta Trop1966，23，2： | 1 |
| 12 | Estimation of the evapotranspiration rate from diurnal groundwater level fluctuations in the Okavango Delta, Botswana显示文摘 | Bauer P Thabeng G Stauffer F | 2004 | Journal of Hydrology2004，288，34： | 1 |
| 13 | A small molecule inhibitor of the Wnt antagonist secreted frizzledrelated protein-1stimulates bone formation显示文摘 | BODINE P V STAUFFER B PONCE-de-LEON H | 2009 | Bone2009，44，6： | 1 |
| 14 | Imidazo quinolines as inhibitors of the PI3K/PKB - pathway 显示文摘 | Stauffer F Maira SM Furet P | 2008 | Bioorg Med Chem Lett2008，18，3： | 1 |
| 15 | Performance of a real - time pseudodynamic test system considering nonlinear structural response 显示文摘 | R Young P B Shing E Stauffer B Thoen | 2007 | Earthquake Engineering and Structural Dynamics2007，36，： | 1 |
| 16 | Parti- tioning Microbial Respiration Between Jet Fuel and Native Organic Matter in an Organic-Rich Long Time-Contaminated Aquifer显示文摘 | Bugna G C Chanton J P Stauffer T B | 2005 | Chemosphere2005，60，2： | 1 |
| 17 | The New Low Stick Stop in Field Hockey显示文摘 | Stauffer P A | 1988 | Schol Coach1988，57，7： | 1 |
| 18 | Pleomorphic adenoma of the parotid gland:histopathologic analysis of the capsular characteristics of 218 tumors显示文摘 | Zbaren P Stauffer E | 2007 | Head Neck2007，29，8： | 1 |
| 19 | Hyperthermia, radiation and chemothera- py : the role of heat in multidisciplinary cancer care 显示文摘 | Hurwitz M Stauffer P | 2014 | Semin Oncol2014，41，6： | 1 |
| 20 | Simulation consensus model of never changed opinions in Sznajd consensus model using multi-spin coding显示文摘 | stauffer D Oliveira P M C | 2002 | Eprint2002，，02： | 1 |
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