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| 1 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011，17，41： | 4 |
| 2 | Dynamic-mechanical and differential scanning calorimetry measurements on crosslinked poly (ester-siloxane) -urethanes显示文摘 | IOAN S GRIGORESCU G STANCIU A | 2001 | Polymer2001，42，： | 1 |
| 3 | Effect of segmented,poly (ester-siloxane) urethanes compositional parameters on differential scanning calorimetry and dynamic-mechanical measurements显示文摘 | IOAN S GRIGORESCU G STANCIU A | 2002 | Eur Polym J2002，38，： | 1 |
| 4 | Formation of β′1 stress-induced martensite in the presence of-phase,in a Cu-Al-Ni-Mn-Fe shape memory alloy显示文摘 | STANCIU S BUJOREANU L G | 2008 | Materials Science and Engineering A2008，，： | 1 |
| 5 | Gastroparesis and its management显示文摘 | Stanciu G | 2001 | Rev Med Chir Soc Med Nat Iasi2001，105，3： | 1 |
| 6 | In vitro antioxidant capacity of honeybee- collected pollen of selected floral origin harvested from Romania 显示文摘 | MARGHITAS L A STANCIU O G OLTICA G S | 2009 | Food Chemistry2009，115，3： | 1 |
| 7 | Occurrence of PAHs and PCBs in petrochemical wastewater 显示文摘 | DOBRINAS S STANCIU G CHIRILA E | 2011 | Ovidius University Annals of Chemistry2011，22，1： | 1 |
| 8 | Gastroparesis and its ,management 显示文摘 | Stanciu G O | 2001 | Rev Med Chir Soc Med Nat Iasi2001，105，3： | 1 |
| 9 | In vitro antioxidant capacity of honeybee-collected pollen of selected floral origin harvested from Romania显示文摘 | MARGHITAS L A STANCIU O G OLTICA G S | 2009 | Food Chemistry2009，115，3： | 1 |
| 10 | Gastroparesis and its management显示文摘 | Stanciu G | 2001 | Rew Med Chir Soc Med Nat lasii2001，105，3： | 1 |
| 11 | Effect of segmented poly(ester-siloxane)urethanes compositional parameters on differential scanning calorimetry and dynamic-mechanical measurements显示文摘 | S Ioan G Grigorescu A Stanciu | 2002 | European Polymer Journal2002，，11： | 1 |
| 12 | Gastroparsis and its management显示文摘 | Stanciu G O | | 0，，03： | 1 |
| 13 | In vitro antioxidant capacity of honeybee-collected pollen of selected floral origin harvested from Romania显示文摘 | Marghitas L A Stanciu O G Dezmirean D S | 2009 | Food Chemistry2009，115，3： | 1 |
| 14 | In vitro antioxidant capacity of honeybee - collected pollen of selected floral origin harvested from Romania 显示文摘 | Marghitas L A Stanciu O G Dezmirean D S | 2009 | Food Chemistry2009，115，： | 1 |
| 15 | Investigating Psychometric and Body Pressure Distribution Responses to Automotive Seating Comfort显示文摘 | Milivojevich A Stanciu R Russ A Blair G R Heumen J D | 2000 | SAE Technical Paper Series2000，，： | 1 |
| 16 | Influence of atomic force microscopy acquisition pa- rameters on thin film roughness analysis 显示文摘 | HRISTU R STANCIU S G STANCIU G A | 2012 | MicroscRes Tech2012，75，7： | 1 |
| 17 | Gastroparesis and its management显示文摘 | Stanciu G | 2001 | Rev Med Chir Soc Med Nal lasi2001，105，3： | 1 |
| 18 | Gastroparesis and its management显示文摘 | Stanciu G | 2001 | Rev Med Chir Soc Med Nat Iasi2001，105，3： | 1 |
| 19 | MRI of intracranial subependymomas显示文摘 | Silverstein J E Lenchik L Stanciu M G | 1995 | J Comput Assist Tomogr1995，19，2： | 1 |
| 20 | in vitro Antioxidant capacity of honeybee-collected pollen of selected floral origin harvested from Romania显示文摘 | MARGHITAS L A STANCIU O G OLTICA G S | 2009 | Food Chemistry2009，115，3： | 1 |
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