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| 1 | PBL教学法与CBL教学法的比较——基于两种教学法的转换在临床课程学习上的效果分析显示文摘本文通过调查加州大学洛杉矶分校(UCLA)和加州大学戴维斯分校(UCD)学生和教师对以问题为基础的学习(PBL)和以案例为基础的学习(CBL)的认知和感受,结果发现,89%的学生和84%的教师更倾向于CBL教学法,两校教师和学生都认为CBL的引导式探究优于PBL的开放式探究。 | Srinivasan M 夏颖 顾鸣敏 | 2009 | 复旦教育论坛2009，7，5： | 139 |
| 2 | 能源植物甜高粱种质资源和分子生物学研究进展显示文摘世界能源危机和全球生态环境日益恶化迫使人们急需开发可再生能源。生物质能源作为一种清洁的可再生能源已受到世界各国的高度重视。发展生物质能源的瓶颈之一是生物质原料不足。甜高粱的生物学产量和含糖量极高,同时兼有耐旱、耐涝、耐贫瘠和耐盐碱等诸多优良特性,被认为是最具开发潜力的能源植物之一。该文从甜高粱的分类学、生物学特点、种质资源评价、功能基因以及基因组信息等方面综述了甜高粱的最新研究进展和存在的问题,并展望了甜高粱作为能源植物的研发前景。 | 刘公社 周庆源 宋松泉 景海春 谷卫彬 李晓峰 苏蔓 Ramachandran Srinivasan | 2009 | 植物学报2009，44，3： | 56 |
| 3 | 基于博弈论的信息安全技术评价模型显示文摘信息安全在企业信息系统建设中越来越重要,如何评价信息安全技术成为当前的一个研究课题.文中基于博弈论,对由防火墙、入侵检测系统和容忍入侵技术构成的三层安全体系结构进行了分析,提出了对信息安全技术进行评价的模型.在对入侵检测系统分析评价的基础上,重点分析了防火墙、入侵检测与容忍入侵的相互影响和关系.研究表明,IDS的检测率、误报率与防火墙的性能有密切关系,系统安全配置直接影响信息安全机制的性能和成本效益,容忍入侵机制取决于入侵的损失评估、系统的成本和防火墙与IDS的性能.信息安全机制的优化配置对于信息安全的效果具有重要影响. | 朱建明 Srinivasan Raghunathan | 2009 | 计算机学报2009，32，4： | 42 |
| 4 | Treatment of taste and odor causing compounds 2-methyl isoborneol and geosmin in drinking water:A critical review显示文摘Problems due to the taste and odor in drinking water are common in treatment facilities around the world.Taste and odor are perceived by the public as the primary indicators of the safely and acceptability of drinking water and are mainly caused by the presence of two semi-volatile compounds-2-methyl isoborneol (MIB) and geosmin.A review of these two taste and odor causing compounds in drinking water is presented.The sources for the formation of these compounds in water are discussed alongwith the health and regulatory implications.The recent developments in the analysis of MIB/geosmin in water which have allowed for rapid measurements in the nanogram per liter concentrations are also discussed.This review focuses on the relevant treatment alternatives,that are described in detail with emphasis on their respective advantages and problems associated with their implementation in a fullscale facility.Conventional treatment processes in water treatment plants,such as coagulation,sedimentation and chlorination have been found to be ineffective for removal of MIB/geosmin.Studies have shown powdered activated carbon,ozonation and biofiltration to be effective in treatment of these two compounds.Although some of these technologies are more effective and show more promise than the others,much work remains to be done to optimize these technologies so that they can be retrofitted or installed with minimal impact on the overall operation and effectiveness of the treatment system. | Rangesh Srinivasan George A.Sorial | 2011 | Journal of Environmental Sciences2011，23，1： | 41 |
| 5 | Genome-wide Expansion and Expression Divergence of the Basic Leucine Zipper Transcription Factors in Higher Plants with an Emphasis on Sorghum显示文摘Plant bZIP transcription factors play crucial roles in multiple biological processes.However,little is known about the sorghum bZIP gene family although the sorghum genome has been completely sequenced.In this study,we have carried out a genome-wide identification and characterization of this gene family in sorghum.Our data show that the genome encodes at least 92 bZIP transcription factors.These bZIP genes have been expanded mainly by segmental duplication.Such an expansion mechanism has also been observed in rice,arabidopsis and many other plant organisms,suggesting a common expansion mode of this gene family in plants.Further investigation shows that most of the bZIP members have been present in the most recent common ancestor of sorghum and rice and the major expansion would occur before the sorghum-rice split era.Although these bZIP genes have been duplicated with a long history,they exhibited limited functional divergence as shown by nonsynonymous substitutions (Ka)/synonymous substitutions (Ks) analyses.Their retention was mainly due to the high percentages of expression divergence.Our data also showed that this gene family might play a role in multiple developmental stages and tissues and might be regarded as important regulators of various abiotic stresses and sugar signaling. | Jizhou Wang Junxia Zhou Baolan Zhang Jeevanandam Vanitha Srinivasan Ramachandran Shu-Ye Jiang | 2011 | Journal of Integrative Plant Biology2011，53，3： | 41 |
| 6 | A gist of gastrointestinal stromal tumors: A review显示文摘Gastrointestinal stromal tumors (GISTs) have been recognized as a biologically distinctive tumor type, different from smooth muscle and neural tumors of the gastrointestinal tract (GIT). They constitute the majority of gastrointestinal mesenchymal tumors of the GIT and are known to be refractory to conventional chemotherapy or radiation. They are defined and diagnosed by the expression of a proto-oncogene protein detected by immunohistochemistry which serves as a crucial diagnostic and therapeutic target. The identification of these mutations has resulted in a better understanding of their oncogenic mechanisms. The remarkable antitumor effects of the molecular inhibitor imatinib have necessitated accurate diagnosis of GIST and their distinction from other gastrointestinal mes-enchymal tumors. Both traditional and minimally invasive surgery are used to remove these tumors with minimal morbidity and excellent perioperative outcomes. The revolutionary use of specific, molecularlytargeted therapies, such as imatinib mesylate, reduces the frequency of disease recurrence when used as an adjuvant following complete resection. Neoadjuvant treatment with these agents appears to stabilize disease in the majority of patients and may reduce the extent of surgical resection required for subsequent complete tumor removal. The important interplay between the molecular genetics of GIST and responses to targeted therapeutics serves as a model for the study of targeted therapies in other solid tumors. This review summarizes our current knowledge and recent advances regarding the histogenesis, pathology, molecular biology, the basis for the novel targeted cancer therapy and current evidence based management of these unique tumors. | Ashwin Rammohan Jeswanth Sathyanesan Kamalakannan Rajendran Anbalagan Pitchaimuthu Senthil-Kumar Perumal UP Srinivasan Ravi Ramasamy Ravichandran Palaniappan Manoharan Govindan | 2013 | World Journal of Gastrointestinal Oncology2013，5，6： | 27 |
| 7 | Anti-diabetic activity of quercetin extracted from Phyllanthus emblica L.fruit: In silico and in vivo approaches显示文摘In this study, molecular interactions of the ligands, quercetin, gallic acid, and metformin with various diabetes mellitus-related protein targets, such as glycogen phosphorylase and peroxisome proliferatoractivated receptor gamma, were assessed. It was revealed that quercetin possesses good binding affinity to both targets. Quercetin is a major constituent of methanolic extracts of Phyllanthus emblica fruit. The antihyperglycemic effect of quercetin in streptozotocin(STZ)-induced diabetic rats was examined. The isolated quercetin administered at a dose of 75 mg/kg body weight produced a maximum decrease of14.78% in blood glucose levels in the diabetic rats after 7 days of treatment. Furthermore, quercetin doses of 50 and 75 mg/kg were shown to significantly improve the profiles of triglycerides, high-density lipoprotein, very-low-density lipoprotein, low-density lipoprotein, and total cholesterol at the end of the study in STZ-induced diabetic rats. The administration of quercetin(25, 50, and 75 mg/kg body weight)daily for 28 days in STZ-induced diabetic rats resulted in a significant decrease in blood glucose and urine sugar levels, with a considerable rise in plasma insulin and hemoglobin levels. Therefore, quercetin is a potential drug with antidiabetic and antihyperglycemic action mediated by changes in the levels of glucose, cholesterol, and triglycerides as indicated by in silico and in vivo studies. | Prabhu Srinivasan S.Vijayakumar Swaminathan Kothandaraman Manogar Palani | 2018 | Journal of Pharmaceutical Analysis2018，8，2： | 18 |
| 8 | Ruptured hepatocellular carcinoma following chemoembolization:a western experience显示文摘BACKGROUND: Transcatheter arterial chemoembolization (TACE) is a recommended first line therapy for unresectable hepatocellular carcinoma (HCC). Serious complications such as neutropenic sepsis and hepatic decompensation are well known, but rupture of HCC following TACE is a rare and potentially fatal complication. The aim of this study was to identify the incidence of ruptured HCC following TACE and the associated risk factors. METHODS: A retrospective analysis was performed using our liver database with 'chemoembolization', 'ruptured HCC' covering the patients who received chemoembolization from January 1995 to December 2005. There were no exclusions. RESULTS: A total of 294 patients received chemoemboliza- tion in 530 sessions during the 10-year period. Of these, 2 ruptured following treatment (incidence 0.68%). The mean age was 65 years and the interval between the treatment and rupture was 2 and 24 days. The common factors were male sex, large tumor size (range 11-13 cm), and exophytic tumor growth. One patient died 2 days after rupture with hepatic decompensation while the second is alive after a 6-month follow up without tumor recurrence. CONCLUSIONS: Ruptured HCC following TACE is a rare but serious complication. Large tumor size, male sex, and exophytic growth of tumor may be predisposing factors for rupture. | Narendra Battula Parthi Srinivasan Mansoor Madanur Srinivas Prabhu Chava Oliver Priest Mohamed Rela Nigel Heaton | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，1： | 17 |
| 9 | Chronic haemorrhagic radiation proctitis: A review显示文摘Chronic haemorrhagic radiation proctitis(CHRP) is a difficult problem faced by the patients following radiation for pelvic malignancy. There is no standardtreatment for this condition, but many methods of treatment are available. The aim of this study was to review the literature to see whether there is an improvement in the available evidence in comparison with previously published systematic reviews in treating patients with CHRP. The Pub Med/Medline database and Google Scholar search was selectively searched. Studies, which treated patients with rectal bleeding due to chronic radiation proctitis or CHRP, were included. Seventy studies were finally selected out of which 14 were randomized controlled clinical trials. Though these studies could not be compared, it could be seen that there was an improvement in the methodology of the studies. There was an objective assessment of symptoms, signs and an objective assessment of outcomes. But, still, there were only a few studies that looked into the quality of life following treatment of CHRP. To increase recruitment to trials, a national registry of cases with established late radiation toxicity would facilitate the further improvement of such studies. Some of the conclusions that could be reached based on the available evidence are 4% formalin should be the first line treatment for patients with CHRP. Formalin and argon plasma coagulation(APC) are equally effective, but formalin is better for severe disease. Refractory patients, not responding to formalin or APC, need to be referred for hyperbaric oxygen therapy or surgery. Radio-frequency ablation is a promising modality that needs to be studied further in randomized trials. | Vishnu Prasad Nelamangala Ramakrishnaiah Srinivasan Krishnamachari | 2016 | World Journal of Gastrointestinal Surgery2016，8，7： | 15 |
| 10 | Studies on electroless Ni-P-Cr_2O_3 and Ni-P-SiO_2 composite coatings显示文摘本文对化学镀镍及化学镀镍磷基质中SiO2与Cr2O3的共沉积进行了研究。微粒在不断生长的膜层中共沉积引起了新的化学复合镀层的出现,这些复合镀层许多都具有优异的耐磨及耐蚀性能。通过选取镀层合金/复合微粒/金属基体的组分可改进镀层,获得所需的性能,以满足特别的需求。在对这些复合镀层的应用需求正在迫近与增长的同时,其市场正在迅速扩张。本文开发出了一种合适的复合化学镀镍液,并通过维氏硬度法对化学复合镀镍层进行了表征。采用动电位极化及交流阻抗法测定了镀层的Taber耐磨性能及耐蚀性能。采用SEM及XRD对复合镀层的表面形貌进行了分析。 | KARTHIKEYAN S SRINIVASAN K N VASUDEVAN T JOHN S | 2007 | 电镀与涂饰2007，26，1： | 15 |
| 11 | Gastrointestinal manifestations of Henoch-Schonlein purpura: A report of two cases显示文摘Henoch-Schonlein purpura(HSP) is a small vessel vasculitis mediated by type Ⅲ hypersensitivity with deposition of Ig A immune complex in the walls of vessels. It is a multi-system disorder characterizedby palpable purpura, arthritis, glomerulonephritis and gastrointestinal manifestations and commonly occurs in children and young adults. The patients with gastrointestinal involvement usually present with colicky abdominal pain, vomiting and melena. The imaging findings include multifocal bowel thickening with mucosal hyperenhancement, presence of skip areas, mesenteric vascular engorgement, with involvement of unusual sites like stomach, duodenum and rectum. These imaging findings in a child or young adult with appropriate clinical findings could suggest HSP. | Parameswaran Prathiba Rajalakshmi Kalyanasundaram Srinivasan | 2015 | World Journal of Radiology2015，7，3： | 12 |
| 12 | Physical Safety and Cyber Security Analysis of Multi-Agent Systems:A Survey of Recent Advances显示文摘Multi-agent systems(MASs)are typically composed of multiple smart entities with independent sensing,communication,computing,and decision-making capabilities.Nowadays,MASs have a wide range of applications in smart grids,smart manufacturing,sensor networks,and intelligent transportation systems.Control of the MASs are often coordinated through information interaction among agents,which is one of the most important factors affecting coordination and cooperation performance.However,unexpected physical faults and cyber attacks on a single agent may spread to other agents via information interaction very quickly,and thus could lead to severe degradation of the whole system performance and even destruction of MASs.This paper is concerned with the safety/security analysis and synthesis of MASs arising from physical faults and cyber attacks,and our goal is to present a comprehensive survey on recent results on fault estimation,detection,diagnosis and fault-tolerant control of MASs,and cyber attack detection and secure control of MASs subject to two typical cyber attacks.Finally,the paper concludes with some potential future research topics on the security issues of MASs. | Dan Zhang Gang Feng Yang Shi Dipti Srinivasan | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，2： | 12 |
| 13 | Embolization of liver tumors:Past,present and future显示文摘Curative therapies for hepatocellular carcinoma(HCC),such as resection and liver transplantation,can only be applied in selected patients with early tumors.More advanced stages require local or systemic therapies.Resection of HCC offers the only hope for cure.Even in patients undergoing resection,recurrences are common.Chemoembolization,a technique combining intraarterial chemotherapy with selective tumor ischemia,has been shown by randomized controlled trials to be efficacious in the palliative setting.There is now renewed interest in transarterial embolization/transarterial chemoembolization(TACE) with regards to its use as a palliative tool in a combined modality approach,as a neoadjuvant therapy,in bridging therapy before transplantation,for symptomatic indications,and even as an alternative to resection.There have also been rapid advances in the agents being embolized trans-arterially(genes,biological response modifiers,etc.).The current review provides an evidence-based overview of the past,present and future trends of TACE in patients with HCC. | Ashwin Rammohan Jeswanth Sathyanesan Sukumar Ramaswami Anand Lakshmanan Perumal Senthil-Kumar Ulagendra Perumal Srinivasan Ravi Ramasamy Palaniappan Ravichandran | 2012 | World Journal of Radiology2012，4，9： | 11 |
| 14 | Prevalence and predictors of nonalcoholic fatty liver disease in South Asian women with polycystic ovary syndrome显示文摘BACKGROUND Polycystic ovary disease(PCOS)may be a risk factor for nonalcoholic fatty liver disease(NAFLD)due to common pathogenetic pathways,including insulin resistance and obesity.Both PCOS and NAFLD are more severe in South Asian women.Data on NAFLD in South Asian women with PCOS are lacking.AIM To investigate prevalence and predictors of NAFLD and liver fibrosis in PCOS patients from South Asia.METHODS We conducted an observational routine screening program by means of transient elastography(TE)with associated controlled attenuation parameter(CAP).NAFLD was defined as CAP≥288 decibels per meter.Significant liver fibrosis(stage 2 and higher out of 4)was defined as TE measurement≥8.0 kilopascals.Elevated alanine aminotransferase(ALT)was defined as ALT>24 IU/L,as per upper limit of normal reported in South Asian women.Biochemical hyperandrogenism was defined as free androgen index>5.Predictors of NAFLD were determined by logistic regression analysis.RESULTS 101 PCOS patients(mean age 36.3 years)with no significant alcohol intake or viral hepatitis were included.Prevalence of NAFLD and significant liver fibrosis was 39.6% and 6.9%,respectively.Elevated ALT was observed in 40%and 11.5%of patients with and without NAFLD,respectively.After adjusting for duration of PCOS and insulin resistance measured by homeostasis model for assessment of insulin resistance,independent predictors of NAFLD were higher body mass index[adjusted odds ratio(aOR)1.30,95% confidence interval(CI):1.13-1.52],hyperandrogenism(aOR:5.32,95%CI:1.56-18.17)and elevated ALT(aOR:3.54,95%CI:1.10-11.47).Lifetime cardiovascular risk was higher in patients with NAFLD compared to those without NAFLD(0.31±0.11 vs 0.26±0.13).CONCLUSION Despite their young age,NAFLD diagnosed by TE with CAP is a frequent comorbidity in South Asian women with PCOS and is strongly associated with higher body mass index and hyperandrogenism.Non-invasive screening strategies could help early diagnosis and initiation of interventions,including counselling on weight loss,cardiovascular risk stratification and linkage to hepatology care where appropriate. | Mohamed Shengir Srinivasan Krishnamurthy Peter Ghali Marc Deschenes Philip Wong Tianyan Chen Giada Sebastiani | 2020 | World Journal of Gastroenterology2020，26，44： | 11 |
| 15 | Corrosion behavior of Mg-Mn-Ca alloy:Influences of Al,Sn and Zn显示文摘The effects of different elements including Al,Sn and Zn with ability of solution hardening on corrosion behavior of a Mg alloy have been studied.The microstructure was analyzed and the electrochemical and immersion techniques were used for corrosion studies.Scanning kelvin probe force microscopy(SKPFM)was utilized to analyze the volta-potential distribution on the surface.It was found that all additives reduced the corrosion resistance;however,Zn decreased the corrosion resistance less than Al and Sn.The corrosion rate was quantitatively explained through volta-potential difference and the second phase fraction. | Ahmad Bahmani Srinivasan Arthanari Kwang Seon Shin | 2019 | Journal of Magnesium and Alloys2019，7，1： | 10 |
| 16 | Formulation of corrosion rate of magnesium alloys using microstructural parameters显示文摘Up to the date of writing this article,a quantitative analysis between corrosion rate and combined microstructural parameters including composition,grain size,and precipitations has not been reported.Hence,a literature review was carried out on these parameters to understand the quantitative effect of each one on the corrosion rate of Mg and Mg alloys.Moreover,using the available data in the literature and several experimental results,a new model was developed to predict the corrosion rate,through microstructural parameters.This model suggests that by using ultra-fined grains,alloying compounds with low Volta-potential difference relative to the matrix and a low fraction of secondary phase,a very low corrosion rates of materials are achievable. | Ahmad Bahmani Srinivasan Arthanari Kwang Seon Shin | 2020 | Journal of Magnesium and Alloys2020，8，1： | 9 |
| 17 | Quantum dot lasers for silicon photonics [Invited]显示文摘We review recent advances in the field of quantum dot lasers on silicon. A summary of device performance,reliability, and comparison with similar quantum well lasers grown on silicon will be presented. We consider the possibility of scalable, low size, weight, and power nanolasers grown on silicon enabled by quantum dot active regions for future short-reach silicon photonics interconnects. | Alan Y.Liu Sudharsanan Srinivasan Justin Norman Arthur C.Gossard John E.Bowers | 2015 | Photonics Research2015，3，5： | 8 |
| 18 | Inverse opal manganese dioxide constructed by few-layered ultrathin nanosheets as high-performance cathodes for aqueous zinc-ion batteries显示文摘Considering the high safety,low-cost and high capacity,aqueous zinc ion batteries have been a potential candidate for energy storage ensuring smooth electricity supply.Herein,we have synthesized inverse opal manganese dioxide constructed by few-layered ultrathin nanosheets by a solution template method at mild temperature.The ultrathin nanosheets with the thickness as small as 1 nm are well separated without obvious aggregation.Used as cathode material for aqueous zinc ion batteries,the few-layered ultrathin nanosheets combined with the inverse opal structure guarantee excellent performance.A high specific discharge capacity of 262.9 mAh·g^-1 is retained for the 100th cycle at a current density of 300 mA·g^-1 with a high capacity retention of 95.6%.A high specific discharge capacity of 121 mAh·g^-1 at a high current density of 2,000 mA·g^-1 is achieved even after 5,000 long-term cycles.The ex-situ X-ray diffraction (XRD) patterns,selected-area electron diffraction (SAED) patterns and high-resolution transmission electron microscopy (HRTEM) results demonstrate that the discharge/charge processes involve the reversible formation of zinc sulfate hydroxide hydrate on the cathode while in-plane crystal structure of the layered bimessite MnO2 could be maintained.This unique structured MnO2 is a promising candidate as cathode material for high capacity,high rate capability and long-term aqueous zinc-ion batteries. | Hao Ren Jin Zhao Lan Yang Qinghua Liang Srinivasan Madhavi Qingyu Yan | 2019 | Nano Research2019，12，6： | 8 |
| 19 | (Ni_(0.8)Zn_(0.2)Fe_2O_4)_(epoxy)-PZT双层膜中的磁电效应显示文摘讨论了Ni0·8Zn0·2Fe2O4(NZFO)与锆钛酸铅(PZT)的双层膜结构样品的磁电(ME)效应.NZFO粉料由溶胶-凝胶法制成,再经900℃热压,并高温烧结.在该双层膜中测量到了很强的磁电相互作用.发现横向的磁电效应比纵向效应大一个数量级,并且随NZFO烧结温度的提高而增加.当烧结温度从950℃上升到1380℃时,横向ME电压系数(αE)的最大值变化范围为25·6mV Am-2≤αE≤199·6mV Am-2.理论分析显示NZFO-PZT双层膜样品中ME效应源于NZFO与PZT之间相对良好的磁电耦合. | 张茹 王淼 张宁 Srinivasan G | 2006 | 物理学报2006，55，5： | 8 |
| 20 | Tissue differential expression of lycopene β-cyclase gene in papaya显示文摘Carotene pigments in flowers and fruits are distinct features related to fitness advantages such as attracting insects forpollination and birds for seed dispersal.In papaya,the flesh color of the fruit is considered a quality trait that correlateswith nutritional value and is linked to shelf-life of the fruit.To elucidate the carotenoid biosynthesis pathway in papaya,we took a candidate gene approach to clone the lycopene β-cyclase gene,LCY-B.A papaya LCY-B ortholog,cpLCY-B,was successfully identified from both cDNA and bacterial artificial chromosome(BAC)libraries and complete genomicsequence was obtained from the positive BAC including the promoter region.This cpLCY-B shared 80% amino acididentity with citrus LCY-B.However,full genomic sequences from both yellow- and red-fleshed papaya were identical.Quantitative real-time PCR(qPCR)revealed similar levels of expression at six different maturing stages of fruits forboth yellow-and red-fleshed genotypes.Further expression analyses of cpLCY-B showed that its expression levels wereseven- and three-fold higher in leaves and,respectively,flowers than in fruits,suggesting that cpLCY-B is down-regulatedduring the fruit ripening process. | Rachel L Skelton Qingyi Yu Rajeswari Srinivasan Richard Manshardt Paul H Moore Ray Ming | 2006 | Cell Research2006，16，8： | 8 |
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