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| 1 | Hypolipidemic and antioxidant effect of polyphenol-rich extracts from Moroccan thyme varieties显示文摘 | Mhamed Ramchoun Hicham Harnafi Chakib Alem Berthold Büchele Thomas Simmet Mustapha Rouis Fouad Atmani Souliman Amrani | 2012 | e-SPEN Journal2012，，3： | 2 |
| 2 | Phenolic extract from Ocimum basilicum restores lipid metabolism in Triton WR-1339-induced hyperlipidemic mice and prevents lipoprotein-rich plasma oxidation显示文摘In this study we investigated the hypolipidemic and anti-lipoprotein-oxidation activities of phenolic extract from sweet basil a popular culinary herb.The hypolipidemic activity was studied in mice model injected intraperitoneally with Triton WR-1339 at a dose of 200 mg/kg body weight.The animals were grouped as follows:normolipidemic control group(n=8),hyperlipidemic control group(n=8)and phenolic extract-treated group(n=8)at a dose of 200 mg/kg body weight.After 7 h and 24 h treatment,the oral administration of the phenolic extract exerts a significant reduction of plasma total cholesterol,triglycerides and LDL-cholesterol concentrations(P<0.001).On the other hand,we demonstrated that the phenolic extract prevents plasma lipid oxidation by 16%(P<0.001),20%(P<0.001),32%(P<0.001)and 44%(P<0.001)at a doses of 10,25,50 and 100g/mL,respectively.The results were compared with ascorbic acid used as standard synthetic antioxidant.HPLC analysis shows that the extract contains 4 major phenolics and is especially rich in rosmarinic acid.This finding indicates that the phenolic extract might be beneficial in lowering hyperlipidemia and preventing atherosclerosis. | Ilham Touiss Saloua Khatib Oussama Bekkouch Souliman Amrani Hicham Harnafi | 2017 | Food Science and Human Wellness2017，6，1： | 1 |
| 3 | Anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts from Moroccan thyme varieties显示文摘Objective: To evaluate the anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts of thyme varieties from Moroccan.Methods: The aqueous extracts of tree medicinal plants [Thymus atlanticus(T. atlanticus), Thymus satureioides and Thymus zygis(T. zygis)] were screened for their antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl radical-scavenging, ferric reducing antioxidant power assay, radical scavenging activity method, the inhibition of 2,2'-azobis(2-amidinopropane) dihydrochloride that induces oxidative erythrocyte hemolysis and thiobarbituric acid reactive substances assay. The anti-inflammatory activity of aqueous extracts was evaluated in vivo using croton oil-induced ear edema and carrageenan-induced paw edema in mice and rats, respectively. This extracts were evaluated in vitro for their anticoagulant activity at the different concentrations by partial thromboplastin time and prothrombin time activated. Results: All thyme varieties were found to possess considerable antioxidant activity and potent anti-inflammatory activity in the croton oil-induced edema. Administration of aqueous extracts of two varieties(50 mg/kg)(T. zygis and T. atlanticus) reduced significantly the carrageenaninduced paw edema similar to non-steroidal anti-inflammatory drug(indomethacin, 10 mg/kg). In partial thromboplastin time and prothrombin time tests, T. atlanticus and T. zygis extracts showed the strongest anticoagulant activity. In contrast, Thymus satureioides did not show the anticoagulant activity in these tests. Conclusions: All aqueous extracts possess considerable antioxidant activity and are rich in total polyphenol and flavonoid but they act differently in the process of inflammatory and coagulation studied. This study shows great variability of biological activities in thyme varieties. | Tarik Khouya Mhamed Ramchoun Abdelbassat Hmidani Souliman Amrani Hicham Harnafi Mohamed Benlyas Younes Filali Zegzouti Chakib Alem | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，8： | 1 |
| 4 | Vasorelaxant and anti-platelet aggregation effects of aque- ous Ocimum basilicum extract 显示文摘 | Souliman Amrani Hicham Hamafi Dounia Gadi | 2009 | Journal of Ethnophar- macology2009，125，1： | 1 |
| 5 | Ocimum basilicum ethanolic extract decreases cholesterol synthesis and lipid accumulation in human macrophages 显示文摘 | Elena Bravo Souliman Amrani Mohammed Aziz | 2008 | Fitoterapia2008，79，7： | 1 |
| 6 | Hypolipemic activity of polyphenol-rich extracts from Ocimum basilicum in Triton WR-1339-induced hyperlipidemic mice显示文摘 | Hicham Harnafi Hana Serghini Caid Nour el Houda Bouanani Mohammed Aziz Souliman Amrani | 2007 | Food Chemistry2007，，1： | 1 |
| 7 | Vasorelaxant and anti platelet aggregation effects of aqueous Ocirnum basilicum extracl显示文摘 | SOULIMAN AMRANI HICHAM HARNAFI DOUNIA GADI | 2009 | Journal of Ethnopharmacology2009，125，1： | 1 |
| 8 | Investigation of antioxidant and antihemolytic properties of Thymus satureioides collected from Tafilalet Region,south-east of Morocco显示文摘Objective:To examine the antioxidant and antihemolytic activities of the aqueous extract,total polyphenols and total flavonoids of Thymus satureioides(T.satureioides).Methods:This plant was collected from Tafilalet Region of Morocco.The aqueous extract was obtained by cold maceration,and the components were obtained by Soxhlel extraction using solvents of varying polarity.The identification and quantification of phenol(caffeic and rosmarinic acids) and llavones(luteolin 7-glycoside and hesperetin) were carried out by high performance liquid chromatography analysis.Results:Total polyphenol and flavonoids contents in the aqueous extract of T.satureioides were(456.73±6.94) mg caffeic acid equivalent/g of dry plant and(172.79±2.12) mg rutin equivalent/g of dry plant,respectively.Different extracts showed good antioxidant activity.IC_(50)for 1.1-diphenyl-2-picrylhydrazil radical scavenging activity was(0.480±0.010),(0.418±0.005),(43.S91 ±2.467) and(0.510±0.010) mg/niL for the aqueous extract,total polyphenol,flavonoids and trolox,respectively.Also,the extracts showed ferric reducing antioxidant power and the values were(50.79±2.02),(117.51±6.46).(7.03±0.29) and(44.33±7.55) mmol trolox/g for the aqueous extract,total polyphenol,flavonoids and trolox.respectively.Serum levels of malondialdehyde was significantly decreased in comparison with the oxidized control(P<0.00l).They showed good activity against 2.2.-azobis 2-amidinopropane dihydrochloridc induced hemolysis in erythrocytes of rabbit blood.In addition,they ameliorate the half time of hemolysis.Conclusions:Our results provide evidence that aqueous extract,total polyphenols and total flavonoids of T.satureioides exhibit marked antioxidant and antihemolytic activities,thus confirming and justifying the popular uses of this plant to relieve some pains. | Mhamed Ramchoun Khalid Sellam Hicham Harnafi Chakib Alem Mohamed Benlyas Farid Khallouki Souliman Amrani | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，2： | 0 |
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