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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma显示文摘AIM: To determine the genomic changes in hepatitis B virus(HBV) and evaluate their role in the development of hepatocellular carcinoma(HCC) in patients chronically infected with genotype C HBV.METHODS: Two hundred and forty chronic hepatitis B(CHB) patients were subjected and followed for a median of 105 mo. HCC was diagnosed in accordance with AASLD guidelines. The whole X, S, basal core promoter(BCP), and precore regions of HBV were sequenced using the direct sequencing method.RESULTS: All of the subjects were infected with genotype C HBV. Out of 240 CHB patients, 25(10%) had C1653 T and 33(14%) had T1753 V mutation in X region; 157(65%) had A1762T/G1764 A mutations in BCP region, 50(21%) had G1896 A mutation in precore region and 67(28%) had pre-S deletions. HCC occurred in 6 patients(3%). The prevalence of T1753 V mutation was significantly higher in patients who developed HCC than in those without HCC. The cumulative occurrence rates of HCC were 5% and 19% at 10 and 15 years, respectively, in patients with T1753 V mutant, which were significantly higher than 1% and 1% in those with wild type HBV(P < 0.001).CONCLUSION: The presence of T1753 V mutation in HBV X-gene significantly increases the risk of HCC development in patients chronically infected with genotype C HBV. | Danbi Lee Heather Lyu Young-Hwa Chung Jeong A Kim Priya Mathews Elizabeth Jaffee Lei Zheng Eunsil Yu Young Joo Lee Soo Hyung Ryu | 2016 | World Journal of Gastroenterology2016，22，23： | 9 |
| 3 | Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?显示文摘Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and disease.The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the esophagus.Although relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the host.These changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other flora.These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease progression.Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade.Here,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression). | Steve M D'Souza Kevin Houston Lauren Keenan Byung Soo Yoo Parth J Parekh David A Johnson | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 4 | 如何设计高质量针刺临床研究:基于证据的专家共识显示文摘本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。 | 张誉清 焦睿珉 Claudia M Witt 劳力行 刘建平 Lehana Thabane Karen J Sherman Mike Cummings Dawn P Richards Eun-Kyung Anna Kim Tae-Hun Kim Myeong Soo Lee Michael E Wechsler Benno Brinkhaus Jun J Mao Caroline A Smith 岗卫娟 刘保延 刘志顺 刘岩 郑晖 吴佳霓 AloBSO Carrasco-Labra Mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt | 2022 | 英国医学杂志中文版2022，25，6： | 7 |
| 5 | Hyaluronan suppresses lidocaine-induced apoptosis of human chondrocytes in vitro by inhibiting the p53- dependent mitochondrial apoptotic pathway显示文摘瞄准:局部麻醉(LA ) 的 Intra 关节的注射是为治疗学的目的一个普通过程。然而, LA 被发现有毒到关节的软骨,并且 hyaluronan 可以稀释这毒性。在我们调查了 hyaluronan 是否稀释了导致 lidocaine 的 chondrotoxicity 的这研究,并且如果那么,阐明内在的 mechanisms.Methods:人的 chondrocyte 房间线 SW1353 和最新孤立的鼠科的 chondrocytes 在为 72 h 包含 hyaluronan 或 lidocaine 的文化媒介被孵化。房间生存能力用 MTT 试金被评估。房间 apoptosis 与 DAPI 染色, caspase 3/7 活动试金和流动 cytometry 被检测。房间周期分布, ROS 层次和 mitochondrial 膜潜力(Δ Ψ m ) 用流动 cytometry 被决定。p53 和调整 p53 的基因产品的表示与西方的 blotting.Results 被测量:Lidocaine (0.005%− 0.03%) dose-dependently 减少了 SW1353 房间的生存能力。这局部麻醉(0.015% , 0.025%) 导致的 apoptosis, G 2/M 阶段拘捕和 Δ 的损失; Ψ m,和在 SW1353 房间的显著地增加的 ROS 生产。Hyaluronan (50 − 800 μ g/mL ) 独自没与 hyaluronan 影响房间生存能力,而是合作处理(200 μ g/mL ) 在 SW1353 房间的显著地稀释的导致 lidocaine 的 apoptosis 和其它畸形。而且,有 lidocaine 和 hyaluronan 的合作处理显著地减少了在 SW1353 房间的 p53 和它的抄写目标 Bax 和 p21 的层次,尽管有 lidocaine 的处理独自显著地没改变这些蛋白质。类似的结果在前 vivo 被获得有教养的鼠科的 chondrocytes.Conclusion:Hyaluronan 通过禁止 p53 依赖的 mitochondrial apoptotic 小径在 vitro 压制人的 chondrocytes 的导致 lidocaine 的 apoptosis。 | Yoon-Jin LEE Soo A KIM Sang-Han LEE | 2016 | Acta Pharmacologica Sinica2016，37，5： | 7 |
| 6 | A rule based expert system for rapid prototyping system selection 显示文摘 | Masood S H Soo A | 2002 | Robotics and ComputerIntegrated Manufacturing2002，18，4： | 2 |
| 7 | Flexible OLED encapsulated with gas barrier film and adhesive gasket显示文摘 | A Ra Cho Eun Hye Kim Soo Young Park Lee Soon Park | 2014 | Synthetic Metals2014，，： | 2 |
| 8 | Solitary pulmonary nodules: dynamic enhanced multi-detector row CT study and compari son with vascular endothelial growth factor and microvessel density显示文摘 | Chin A Yi Kyung Soo Lee Eun A Kim el al | 2004 | Radiology2004，233，： | 1 |
| 9 | Preparation of block eopolymer vesicles in solution 显示文摘 | Lira Soo P Eisenberg A | 2004 | Journal of Polymer Science Part B: Polymer Physics2004，42，6： | 1 |
| 10 | New CT response criteria in non-small cell lung cancer: Proposal and application in EGFR tyrosine kinase inhibitor therapy显示文摘 | Ho Yun Lee Kyung Soo Lee Myung-Ju Ahn Hye Sun Hwang Ju Won Lee Keunchil Park Jin Seok Ahn Tae Sung Kim Chin A Yi Myung Jin Chung | 2010 | Lung Cancer2010，，： | 1 |
| 11 | Knowl edge network characteristics and entrepreneurial orienta tion of multinational corporations, research policy显示文摘 | CHRISTOPHER W SOO H L RESOURCE A | 2009 | Re search Policy2009，38，8： | 1 |
| 12 | Mechanical properties of talc-and (calcium carbonate )-filled poly (vinyl chloride) hybrid composites 显示文摘 | Soo T B Azman H Aznizam A B | 2012 | J Vinyl Addit Teehn2012，18，2： | 1 |
| 13 | Tool wear/life evaluation when finish turning Inconel 718 using PCBN tooling显示文摘 | Khan S A Soo S L Aspinwall D K | 2012 | Procedia CIRP2012，1，： | 1 |
| 14 | Evapotranspiration and crop coefficient of common reed at the surroundings of Lake Balaton, Hungary显示文摘 | Anda A da Silva J A T Soos G | 2014 | Aquatic Botany2014，116，： | 1 |
| 15 | Screening and quantification of hypnotic sedatives in serum by capillary gas chroma-tography with a nitrogen -phesphorus detector,and confirmation by capillary gas chro- matography - mass spectrometry 显示文摘 | Soo V A Bergert R J And Deutsch D G | 1986 | Clin Chem1986，32，： | 1 |
| 16 | Quantum Dots with Phenylboronic Acid Tags for Specific Labeling of Sialic Acids on Living Cells显示文摘 | LIU A PENG S SOO J C | 2011 | Anal Chem2011，83，3： | 1 |
| 17 | Reversible cerebral vasocon-striction syndrome with posterior leucoencephalopathy after o- ral contraceptive pills显示文摘 | Soo Y Singhal A Leung T | 2010 | Cephalalgia2010，30，1： | 1 |
| 18 | Plant - derived' triterpenoid sweettness inhibitors显示文摘 | Rutt Suttisri IK- Soo Lee A Douglas Kinghorn | | 0，，： | 1 |
| 19 | Intra aortic balloonpump: literature review of risk factors related to complica-tions of the intraaortic balloon pump 显示文摘 | PARISSIS H SOO A AL-ALAO B | 2011 | J CardiothoracSurg2011，6，： | 1 |
| 20 | The effect of bone morphogenetic protein-2 on rat in- tervertebral disc cells in vitro显示文摘 | Tim Yoon S Su Kim K Li J Soo Park J Akamaru T Elmer W A | 2003 | Spine(Phila Pa 1976)2003，28，： | 1 |
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