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| 1 | Oxidative stress modulation in hepatitis C virus infected cells显示文摘Hepatitis C virus(HCV) replication is associated with the endoplasmic reticulum, where the virus can induce cellular stress. Oxidative cell damage plays an important role in HCV physiopathology. Oxidative stress is triggered when the concentration of oxygen species in the extracellular or intracellular environment exceeds antioxidant defenses. Cells are protected and modulate oxidative stress through the interplay of intracellular antioxidant agents, mainly glutathione system(GSH) and thioredoxin; and antioxidant enzyme systems such as superoxide dismutase, catalase, GSH peroxidase, and heme oxygenase-1. Also, the use of natural and synthetic antioxidants(vitamin C and E, N-acetylcysteine, glycyrrhizin, polyenylphosphatidyl choline, mitoquinone, quercetin, S-adenosylmethionine and silymarin) has already shown promising results as co-adjuvants in HCV therapy. Despite all the available information, it is not known how different agents with antiviral activity can interfere with the modulation of the cell redox state induced by HCV and decrease viral replication. This review describes an evidence-based consensus on molecular mechanisms involved in HCV replication and their relationship with cell damage induced by oxidative stress generated by the virus itself and cell antiviral machinery. It also describes some molecules that modify the levels of oxidative stress in HCV-infected cells. | Sonia A Lozano-Sepulveda Owen L Bryan-Marrugo Carlos Cordova-Fletes Maria C Gutierrez-Ruiz Ana M Rivas-Estilla | 2015 | World Journal of Hepatology2015，7，29： | 6 |
| 2 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Genetic diversity of Indian isolates of rice blast pathogen using molecular markers显示文摘 | SONIA C GOPALADRISHNA T | 2005 | Current Science2005，88，9： | 1 |
| 5 | Statistical distributions for air pollution applied to the study of the particulate problem in Santiago显示文摘 | Benoit M Sonia Y Luis C | 1999 | Atmospheric Environment1999，33，16： | 1 |
| 6 | Genetic interaction between ABA,ethylene and sugar signaling pathways显示文摘 | Sonia G Peter M C | 2001 | Curr Opin Plant Biology2001，4，： | 1 |
| 7 | Political Control and Performance in China's Listed Firms显示文摘 | Chang Eric C Sonia M.L Wong | | 0，，32： | 1 |
| 8 | Purification and partial amino acid sequence of thuricin S,a new anti-Listeria bacteriocin from Bacillus thuringiensis显示文摘 | Sonia C Francois D Sophie S | | 0，，02： | 1 |
| 9 | Involvement of flavanoids in beer color instability during Ssorage显示文摘 | DELPINE CALLEMIEN SONIA C | 2007 | Journal of Agricultural and Food Chemistry2007，55，22： | 1 |
| 10 | Removal of pollutants from indoor air using zeolite membranes显示文摘 | Sonia A Ana C P Marya P B | 2004 | Journal of Membrane Science2004，240，： | 1 |
| 11 | Named entity recognition:Fallacies,challenges and opportunities显示文摘 | Mónica M Julián U Sonia S C | 2013 | Computer Standards & Interfaces2013，35，5： | 1 |
| 12 | Association Between Corticos- teroids and Infection, Sepsis, and Infectious Death in Pediatric A- cute Myeloid Leukemia (AML): Results From theCanadian Infec- tions in AML Research Group 显示文摘 | David D Sonia C Victoria P | 2012 | Clin Infect Dis2012，55，12： | 1 |
| 13 | Final contractor se- lection using the analytical hierarchy process 显示文摘 | PATRICK S W F SONIA K Y C | 2000 | Construction Management and Economics2000，18，5： | 1 |
| 14 | The ultrastructure of the spermatozoon of the lizard Iguana iguana (Reptilia,Squamata,Iguanidae) and the variability of sperm morphology among iguanian lizards显示文摘 | Gustavo H C V Guarino R C Sonia N B | 2004 | Journal of Anatomy2004，204，： | 1 |
| 15 | Residues of pesticides in food: A global environmental preoccupation focussing on apples 显示文摘 | Isabel C Juliano de A Sonia C | 2009 | Qutmica Nova2009，32，4： | 1 |
| 16 | Political Control and Performance in China 's Listed Firms 显示文摘 | Chang Eric C Wong Sonia M L | 2004 | Journal of Comparative Economics2004，，32： | 1 |
| 17 | Mitochondrial reactive oxygen species preconditioning protects brain cells against hyperglycemia显示文摘 | Sonia C Renato X Maria S | 2010 | Alzhe & Dem2010，6，4： | 1 |
| 18 | Neuronalnicotinic acetylcholine receptor from Drosophila two different types of α - Subunit coassemble within the same receptor romplex 显示文摘 | Regine S Sonia B Kathrin C | 2000 | Journal of Neurochemistry2000，74，： | 1 |
| 19 | Early oxidative damage in prima-ry cultured trout hepatocytes:a time course study显示文摘 | MICHELA F SONIA R PAOLO C | 2002 | Aquatic Toxicology2002，59，34： | 1 |
| 20 | An overview of natural polymers for oral insulin delivery显示文摘 | Sonia T A Sharma C P | 2012 | Drug Discovery Today2012，17，1314： | 1 |
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