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您的检索式：作者名="SONG Leping"
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| 1 | Function of Ca^(2+)-/calmodulin-dependent protein kinase Ⅳ in Ca^(2+)-stimulated neuronal signaling and behavior显示文摘The activity of Ca2+/calmodulin-dependent protein kinase IV(Ca MKIV) is sensitive to activity-dependent changes in the level of intracellular Ca2+.Following neuronal stimulation,the activation of Ca MKIV may trigger synaptic modifications and transcriptional responses,both of which are involved in regulating cognitive and emotional behavior.Here,we used Ca MKIV knockout(KO) neurons and mice to examine the function of Ca MKIV in Ca2+-stimulated intracellular signaling and animal behavior,respectively.Following NMDA receptor activation or membrane depolarization,the up-regulation of CREB(c AMP responsive element binding protein) and its target gene Bdnf(brain-derived neurotrophic factor) was intact in cortical neurons obtained from Ca MKIV KO mice.Ca MKIV KO mice displayed severe impairment in contextual fear memory but normal locomotor activity and anxiety level in the contextual training chamber.Although Ca MKIV KO mice showed normal memory in the standard passive avoidance task,they were defective in learning the temporal dissociative passive avoidance task.As indicated by the light/dark test and marble-burying test data,Ca MKIV KO mice showed less anxiety and normal perseveration.In the voluntary wheel-running test,Ca MKIV KO mice showed normal running time and distance but higher maximal running speed.Our results demonstrate the function of Ca MKIV in regulating different forms of fear memory,anxiety,and certain aspect of motor function. | SONG ZiXiang CHEN Qi DING Qi ZHENG Fei LI ChengWei XU LePing WANG HongBing | 2015 | Science China(Life Sciences)2015，58，1： | 6 |
| 2 | Posttreatment of effluent fromcoke-plant wastewater treatment system in seguencing batch reactors显示文摘 | YU Huanqing GU Guowei SONG Leping | 1997 | J Environ Eng1997，123，3： | 1 |
| 3 | Polar plumes observed at the total solar eclipse in 2009显示文摘During the total solar eclipse of July 22, 2009, we carried out a white-light observation in Anji, Zhejiang, China. The aim wasto observe the polar plumes (PPs) with high spatial and temporal resolutions in white-light. With the observational data, weinvestigate the properties and evolution of the PPs and compare them with those of the low-latitude plumes (LPs). We find thatboth the PPs and the LPs have comparable lengths and widths, and the mean length and width are 300 Mm and 16 Mm, re-spectively. The average inclination angle (13 degree) of the PPs is smaller than that (32 degree) of the LPs. Generally, theplumes which are closer to the coronal hole center are more vertical. We trace the PPs and the LPs in the sequence of imagesand find that none of them disappears and no new one is created. Additionally, neither plasma outflow nor transverse oscilla-tion is observed. These imply that the evolution process of plumes is much longer than the timescale of eclipse. | YANG ShuHong ZHANG Jun ZHANG ZhiYong ZHAO ZhaoWang LIU YangBing SONG Qian YANG ShangBin BAO XingMing LI LePing CHU Zhe LI Ting | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，10： | 0 |
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