|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Association between thrombotic risk factors and extent of fibrosis in patients with non-alcoholic fatty liver diseases显示文摘AIM: To evaluate the prevalence of genetic and acquired prothrombotic risk factors and their association with the extent of fibrosis and fatty infiltration in patients with non-alcoholic fatty liver disease (NAFLD).METHODS: Forty-four patients with chronic hepatitis (28 men and 16 women, with mean age of 45±11 and 49±12 years, respectively) constituted the patient population of this study. The groups were divided as follows: 15 patients with fatty liver (FL); 15 with non-alcoholic steatohepatitis (NASH); 14 with chronic viral hepatitis (CH) diagnosed by histology and liver technetium scan or ultrasound; and 10 healthy individuals. Thrombophilic, coagulation factors and genetic mutations were diagnosed by standard hemostatic and molecular coagulation assays.RESULTS: Activated protein C (APC) resistance and protein S were the most prevalent thrombotic risk factors (6% and 10% in NAFLD vs 21% and 14% in CH; P<0.01 and P<0.05, respectively). One thrombotic risk factor was identified in 41% of patients (23% mild fibrosis, 18% severe fibrosis) and two thrombotic risk factors in 6% of patients with NAFLD and severe fibrosis. While no differences in APC ratio, lupus anticoagulant, fibrinogen, factor V Leiden,prothrombin, and MTHFR mutation were found. Protein S levels were significantly lower in NASH patients than in patients with FL alone (92±19 vs106±2, P<0.01). Protein C levels were markedly higher in patients with NAFLD and mild or severe fibrosis as compared to the patients with CH, respectively (128±40 vs96±14, P<0.001 or 129±36 vs 88±13, P<0.01).CONCLUSION: Up to 46% of patients with NAFLD may have thrombotic risk factors, and the presence of thrombotic risk factors is correlated with the extent of hepatic fibrosis,suggesting a crucial role of the coagulation system in the pathogenesis of hepatic fibrosis. | N Assy I Bekirov Y Mejritsky L Solomon S Szvalb O Hussein | 2005 | World Journal of Gastroenterology2005，11，37： | 3 |
| 2 | The aspext of trauma in he bone changes of eongenital lues显示文摘 | I Solomon A Rosen E | 1975 | Pediatr Radiol1975，3，： | 1 |
| 3 | Desiccation stress of entomopathogenic nematodes induces the accumulation of a novel heat-stable protein 显示文摘 | Solomon A Salomon R Paperna I | 2000 | Parasitology2000，121，： | 1 |
| 4 | Activity and safety of crizotinib in patients with ALK -positive non-small-cell lung cancer: updated results from a phase 1 study显示文摘 | D Ross Camidge Yung-Jue Bang Eunice L Kwak A John Iafrate Marileila Varella-Garcia Stephen B Fox Gregory J Riely Benjamin Solomon Sai-Hong I Ou Dong-Wan Kim Ravi Salgia Panagiotis Fidias Jeffrey A Engelman Leena Gandhi Pasi A J?nne Daniel B Costa Geoffrey | 2012 | Lancet Oncology2012，，10： | 1 |
| 5 | Muhicop- per Oxidases and Oxygenases 显示文摘 | SOLOMON E I SUNDARAM U M MACHONKIN T E | 1996 | Chemical Reviews1996，96，7： | 1 |
| 6 | Report on a WHO con- sultation on immunological endpoints for evaluation of new Japanese encephalitis vaccines, WHO, Geneva, 2-3 September, 2004 显示文摘 | Hombach J Solomon T Kurane I | 2005 | Vaecnie2005，23，45： | 1 |
| 7 | Comparative Effects of Application of Coated and Non-Coated Urea in Clayey and Sandy Paddy Soil Mi- crocosms Examined by the ^15 N Tracer Technique 显示文摘 | SOLOMON A KAZUYUKI I | 2004 | Soil Science and Plant Nutrition2004，50，2： | 1 |
| 8 | Tow models of group behavior in the solution of Eureka-type problems 显示文摘 | Lorge I Solomon | 1955 | Psychometrika1955，，20： | 1 |
| 9 | Transdermal delivery of insulin from a novel biphasic lipid system in diabetic rats显示文摘 | King M J Badea I Solomon J | 2002 | Diabetes Technol Ther2002，4，4： | 1 |
| 10 | Inhibition of amyloid precursor protein processing by beta-secretase through site-directed antibodies 显示文摘 | Arbel M Yacoby I Solomon B | 2005 | Proc Natl Acad Sci2005，102，21： | 1 |
| 11 | Economic valuation of environmental services sustained by water flows in the Yaqui River Delta 显示文摘 | Ojedam I Mayer A S Solomon B D | 2008 | Ecological Economics2008，65，1： | 1 |
| 12 | 抗CD25抗体调节机体的细胞免疫应答显示文摘调节T细胞(Treg)是机体免疫调节的重要组成部分,帮助实现了免疫稳态。而在肿瘤中Treg的大量存在造成了促进肿瘤生长的免疫抑制环境,所以特异性的清除Treg一直是肿瘤免疫治疗关注的重点。Treg细胞与效应性T细胞(Teff)的差异之一就是Treg细胞上高表达IL-2的受体CD25分子。而在之前研究中,利用抗CD25的抗体抗肿瘤的效果并不理想,因为Teff细胞,尤其是能够杀伤肿瘤细胞的CTL细胞的激活也需要IL-2的参与,其细胞膜上也不同程度的表达CD25,所以抗CD25的抗体在抑制Treg的同时也可能抑制了Teff功能。 | 李冬(编译) Solomon I Amann M Goubier A | 2021 | 国际老年医学杂志2021，42，2： | 1 |
| 13 | Polynomial Codes over Certain Finite Fields显示文摘 | Reed I S Solomon G | 1960 | Journal of the Society for Industrial and Applied Mathematics1960，8，： | 1 |
| 14 | Biomimetic inorganic chemistry显示文摘 | Richard H Holm Edward I Solomon | 2004 | Chemical Reciews2004，104，2： | 1 |
| 15 | Serum cholesterol changes after midlife and late-life cognitive:twenty-one-year follow up study显示文摘 | Solomon A Kareholt I Ngandu T | | 0，，10： | 1 |
| 16 | What do industry-specialist auditors know? 显示文摘 | Solomon I Shields M Whittington R | 1999 | Journal of Accounting Research1999，37，1： | 1 |
| 17 | Airborne particulate matter and human health:a review显示文摘 | Phalen R F Solomon P A | 2005 | Aerosol Science and Technology2005，39，： | 1 |
| 18 | Polynomial Codes Over Certain Finite Fields显示文摘 | Reed I S Solomon G | 1960 | Journal of the Society for Industrial and Applied Mathematics1960，8，2： | 1 |
| 19 | Multicopper Oxidases and Oxygenases显示文摘 | E I Solomon U M Sundaram T E Machonkin | 1996 | Chem Rev1996，96，： | 1 |
| 20 | The Research in the Relaxation of Heteronuclear System显示文摘 | Solomon I | 1955 | Phys Rev1955，99，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员