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		题名	作者	年代	出处	被引量
	1	Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer显示文摘AIM To investigate the anticancer mechanisms of the monoterpenoid alcohol linalool in human colon cancer cells.METHODS The cytotoxic effect of linalool on the human colon cancer cell lines and a human fibroblast cell line was examined using the WST-8 assay. The apoptosisinducing effect of linalool was measured using the terminal deoxynucleotidyl transferase d UTP nickend labeling assay and flow cytometry with Annexin V. Oxidative stress was investigated by staining for diphenyl-1-pyrenylphosphine, which is a cellular lipid peroxidation marker, and electron spin resonance spectroscopy. Sixteen SCID mice xenografted with human cancer cells were randomized into 3 groups for in vivo analysis: control and low-dose and high-dose linalool groups. The control group was administered tap water orally every 3 d. The linalool treatment groups were administered 100 or 200 μg/kg linalool solution orally for the same period. All mice were sacrificed under anesthesia 21 d after tumor inoculation, and tumors and organs were collected for immunohistochemistry using an anti-4-hydroxynonenal antibody. Tumor weights were measured and compared between groups. RESULTS Linalool induced apoptosis of cancer cells in vitro, following the cancer-specific induction of oxidative stress, which was measured based on spontaneous hydroxyl radical production and delayed lipid peroxidation. Mice in the high-dose linalool group exhibited a 55% reduction in mean xenograft tumor weight compared with mice in the control group(P < 0.05). In addition, tumor-specific lipid peroxidation was observed in the in vivo model.CONCLUSION Linalool exhibited an anticancer effect via cancerspecific oxidative stress, and this agent has potential for application in colon cancer therapy.	Kenichi Iwasaki Yun-Wen Zheng Soichiro Murata Hiromu Ito Ken Nakayama Tomohiro Kurokawa Naoki Sano Takeshi Nowatari Myra O Villareal Yumiko N Nagano Hiroko Isoda Hirofumi Matsui Nobuhiro Ohkohchi	2016	World Journal of Gastroenterology2016，22，44：	5
	2	Helicobacter pyloriinfec-tionand the development of gastric cancer显示文摘	Naomi U Shiro O Soichiro Y	2001	N Engl J Med2001，345，11：	1
	3	显示文摘	Minoru I Soichiro O	1995	Jpn J Appl Phys1995，34，：	1
	4	Helicobacter pylorl infection and the development of gastric cancer显示文摘	Naomi U Shiro O Soichiro Y	2001	N Engl J Med2001，345，11：	1
	5	Preparation of ferroelectric Bi4Ti3O12 thin films with c-axis orientation by atmospheric-pressure metal-organic chemical vapor deposition 显示文摘	KUNIKI Y MINORU I SOICHIRO O	1995	Jpn J Appl Phys1995，34，：	1
	6	Helicobacter pylori infec- tion and the development of gastric cancer显示文摘	Naomi U Shiro O Soichiro Y	2001	N Engl J Med2001，345，11：	1
	7	High production of methyl mercaptan by 1-methionine-α-deamino-γ-mercaptomethane lyase from Treponema denticola 显示文摘	Haruka F Yoshio N Soichiro O	2005	Biochemical and Biophysical Research Communications2005，331，1：	1

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