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| 1 | miRNA expression profiles in cerebrospinal fluid and blood of patients with Alzheimer’s disease and other types of dementia-an exploratory study显示文摘Background:MicroRNAs(miRNAs)are small non-coding RNA molecules that function as posttranscriptional regulators of gene expression.Measurements of miRNAs in cerebrospinal fluid(CSF)and blood have just started gaining attention as a novel diagnostic tool for various neurological conditions.The purpose of this exploratory investigation was to analyze the expression of miRNAs in CSF and blood of patients with Alzheimer’s disease(AD)and other neurodegenerative disorders in order to identify potential miRNA biomarker candidates able to separate AD from other types of dementia.Methods:CSF was collected by lumbar puncture performed on 10 patients diagnosed with AD and 10 patients diagnosed with either vascular dementia,frontotemporal dementia or dementia with Lewy bodies.Blood samples were taken immediately after.Total RNA was extracted from cell free fractions of CSF and plasma,and a screening for 372 known miRNA sequences was carried out by real time quantitative polymerase chain reactions(miRCURY LNA™Universal RT miRNA PCR,Polyadenylation and cDNA synthesis kit,Exiqon).Results:Fifty-two miRNAs were detected in CSF in at least nine out of ten patients in both groups.Among these,two miRNAs(let-7i-5p and miR-15a-5p)were found significantly up-regulated and one miRNA(miR-29c-3p)was found significantly down-regulated in patients with AD compared to controls.One hundred and sixty-eight miRNAs were frequently detected in the blood,among which miR-590-5p and miR-142-5p were significantly up-regulated and miR-194-5p was significantly down-regulated in AD patients compared to controls.Conclusions:Detection of miRNA expression profiles in blood and in particular CSF of patients diagnosed with different types of dementia is feasible and it seems that several expressional differences between AD and other dementia types do exist when measured in a clinically relevant setup.In this explorative pilot study,the deregulated miRNAs in CSF of AD patients may be associated with relevant target genes related to AD pathology,including APP and BACE1,which suggests that miRNAs are interesting candidates for AD biomarkers in the future. | Sofie Sølvsten Sørensen Ann-Britt Nygaard Thomas Christensen | 2016 | Translational Neurodegeneration2016，5，1： | 14 |
| 2 | Engineering properties of inorganic polymer concretes (IPCs)显示文摘 | M Sofi J S J van Deventer P A Mendis | 2007 | Cement and Concrete Research2007，37，： | 1 |
| 3 | The value of serologic markers in indeterminate colitis: A prospective follow-up study显示文摘 | Sofie Joossens Walter Reinisch Séverine Vermeire Boualem Sendid Daniel Poulain Marc Peeters Karel Geboes Xavier Bossuyt Peggy Vandewalle Georg Oberhuber Harald Vogelsang Paul Rutgeerts Jean-Frédéric Colombel | 2002 | Gastroenterology2002，，： | 1 |
| 4 | Engineering Properties of Inorganic Polymer Concretes (IPCs)显示文摘 | Sofi M Deventer J S J Mendis P A | 2007 | Cement and Concrete Research2007，37，： | 1 |
| 5 | Engineering properties of inorganic polymer concretes (IPCs)显示文摘 | SOFI M DEVENTER J S J VAN MENDIS P A | 2007 | Cem Concr Res2007，37，： | 1 |
| 6 | Periprocedural complications and one-year outcomes after catheter ablation for treatment of atrial fibrillation in elderly patients:a nationwide Danish cohort study显示文摘OBJECTIVES To investigate complications within 30-days following first-time ablation for atrial fibrillation(AF),including a composite of cardiac tamponade,hematoma requiring intervention,stroke or death,in patients≥75 years of age,compared to pa-tients aged 65−74 years.In addition,one-year all-cause mortality and AF relapse were compared.METHODS&RESULTS All patients receiving their first catheter ablation for AF between 2012 and 2016 were identified us-ing Danish nationwide registries.Patients aged 65−74 years served as the reference group for patients≥75 years.Relapse of AF within one year was defined as cardioversion following a three-month blanking period,re-ablation or confirmed relapse within follow-up.The composite complication outcome did not differ between the two age groups,with 39/1554(2.8%)in patients 65−74 years of age,versus 5/199(2.5%)in older patients(adjusted HR=0.94),95%CI:0.37−2.39,P=0.896).Patients≥75 years or older had no increased hazard of death within 30 days after the procedure,with an incidence of 3/1554(0.2%)in younger pa-tients and 2/199(1.0%)in patients≥75 years of age(adjusted HR=4.71,95%CI:0.78−28.40,P=0.091).There was no difference in relapse of AF after one year between age groups(≥75 years adjusted HR=1.00,95%CI:0.78-1.26,P=0.969).CONCLUSION In patients≥75 years of age selected for catheter ablation for AF,the incidence of periprocedural complica-tions,as well as one-year freedom from AF showed no statistical difference,when compared to patients 65−74 years of age. | Jesper Nielsen Kristian Hay Kragholm Sofie Brix Christensen Arne Johannessen Christian Torp-Pedersen Steen Buus Kristiansen Peter Karl Jacobsen Peter Steen Hansen Mogens Stig Djurhus Christoffer Polcwiartek Peter Søgaard Anna Margrethe Thøgersen Uffe Jakob Ortved Gang Ole Dan Jørgensen Filip Lyng Lindgren Sam Riahi | 2021 | Journal of Geriatric Cardiology2021，18，11： | 1 |
| 7 | Temperature and moisture controls of C fluxes in grazed subalpine grasslands显示文摘 | Sofie S Rosa L ngela R | 2012 | Arctic Antarctic and Alpine Research2012，44，2： | 1 |
| 8 | Engineering properties of inorganic polymer concretes(IPCs)显示文摘 | Sofi M Van Deventer J S J Mendis P A | 2007 | Cement and Concrete Research2007，37，2： | 1 |
| 9 | Effects of pulsed nutrient inputs on phytoplankton assemblage structure and blooms in an enclosed coastal area显示文摘 | SOFIE S GEORGE T DANIEL B D | 2007 | Estuarine Coastal and Shelf Science2007，73，： | 1 |
| 10 | The effect of intracellu- lar degradation on cytotoxicity and cell labeling efficacy of inorganic ligand - stabilized colloidal CdSe /CdSquantum dots 显示文摘 | SOENEN S J Sofie A MANSHIAN B B | 2015 | Biomed- Nanotechnol2015，11，： | 1 |
| 11 | Engineering Properties of Inorganic Polymer Concretes (IPCs) 显示文摘 | Sofi M Van Deventer J S J Mendis P A | 2007 | Cement and Concrete Research2007，37，： | 1 |
| 12 | Protein Z:'light and shade' of a new thrombotic factor显示文摘 | Sofi F Cesari F Fedi S | 2004 | Clin Lab2004，50，1112： | 1 |
| 13 | Freeze Casting of Aqueous Alumina Slurries with Glycerol显示文摘 | Sofie S W Dogan F | 2001 | J Am Ceram Soc2001，84，7： | 1 |
| 14 | TLR ligands and cytokines induce CXCR3 ligands in endothelial cells:enhanced CXCL9 in autoimmune arthritis显示文摘 | Tamara L Lies D Sofie S | 2006 | Laboratory Investigation2006，86，9： | 1 |
| 15 | Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF‐A and TGFβ2 in vascular abnormalization显示文摘 | Lothar C Dieterich Sofie Mellberg Elise Langenkamp Lei Zhang Agata Zieba Henriikka Salom?ki Martin Teichert Hua Huang Per‐Henrik Edqvist Theo Kraus Hellmut G Augustin Tommie Olofsson Erik Larsson Ola S?derberg Grietje Molema Fredrik Pontén Patrik Georgii‐ | 2012 | J. Pathol2012，，3： | 1 |
| 16 | Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/e1F4E 显示文摘 | Diane C Sofie S Christina T | 2002 | Genes Dev2002，16，12： | 1 |
| 17 | Tissue Kim-I and urinary elusterin as early indicators of cisplatin-induced acute kidney injury in rats 显示文摘 | Petra V Sofie S Erio BT | 2012 | Toxicol Patho12012，40，7： | 1 |
| 18 | Freeze casting of aqueous alumina slurries with glycerol显示文摘 | Sofie S W Dogan F | 2001 | J Am Ceram Soc2001，84，7： | 1 |
| 19 | Treatment of three types of landfill leachate with reverse osmosis显示文摘 | Ann - Sofi S Wimmerstedt | 1995 | Desalination1995，101，1： | 1 |
| 20 | Effect of amlodipine and lisinopril on microalbuminuria in patients with essential hypertension: a prospective study显示文摘 | Jalal S Sofi FA Abass S M | 2010 | Indian J Nephrol2010，20，1： | 1 |
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