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| 1 | Systematic review: The placebo effect of psychological interventions in the treatment of irritable bowel syndrome显示文摘AIM To determine the placebo response rate associated with different types of placebo interventions used in psychological intervention studies for irritable bowel syndrome. METHODS Randomized controlled trials comparing psychological interventions(stress management/relaxation therapy(cognitive) behavioral therapy, short-term psychodynamic therapy, and hypnotherapy) for the treatment of adult patients with irritable bowel syndrome(IBS) diagnosed with the Manning or Rome criteria with an adequate placebo control treatment and reporting data on IBS symptom severity were identified by searching Pub Med, Embase, the Cochrane Library, CINAHL and Psyc INFO databases. Full-text articles that were written in English and published between 1966 and February 2016 in peer-reviewed journals were selected for the present review. Placebo interventions were considered to be adequate if the number of sessions and the amount of time spent with the therapist were the same as in the active treatment. The placebo response rate(PRR) was computed for IBS symptom severity(primary outcome measure) as well as for anxiety, depression and quality of life(secondary outcome measures). RESULTS Six studies, with a total of 555 patients met the inclusion criteria. Four studies used an educational intervention, whereas two studies used a form of supportive therapy as the placebo intervention. The PRR for IBS symptom severity ranged from 25% to 59%, with a pooled mean of 41.4%. The relative PRR for the secondary outcome measures ranged from 0% to 267% for anxiety, 6% to 52% for depression 20% to 125% for quality of life. The PRR associated with pharmacological treatments, treatment with dietary bran and complementary medicine ranged from 37.5% to 47%. Contrary to our expectations, the PRR in studies on psychological interventions was comparable to that in studies on pharmacological, dietary and alternative medical interventions.CONCLUSION The PRR is probably determined to a larger extent by patient-related factors, such as expectations and desire for the treatment to be effective, than the content of the placebo intervention. | Carla E Flik Laura Bakker Wijnand Laan Yanda R van Rood André JPM Smout Niek J de Wit | 2017 | World Journal of Gastroenterology2017,23,12: | 7 |
| 2 | Four-year follow-up of endoscopic gastroplication for the treatment of gastroesophageal reflux disease显示文摘AIM:To evaluate the long-term effect of Endocinch treatment for gastroesophageal reflux disease(GERD).METHODS:After unblinding and crossover,50 patients(32 males,18 females; mean age 46 years) with pH-proven chronic GERD were recruited from an initial randomized,placebo-controlled,single-center study,and included in the present prospective open-label follow-up study.Initially,three gastroplications using the Endocinch device were placed under deep sedation in a standardized manner.Optional retreatment was offered in the first year with 1 or 2 extra gastroplications.At baseline,3 mo after(re) treatment and yearly proton pump inhibitor(PPI) use,GERD symptoms,quality of life(QoL) scores,adverse events and treatment failures(defined as:patients using > 50% of their baseline PPI dose or receiving alternative antireflux therapy) were assessed.Intention-to-treat analysis was performed.RESULTS:Median follow-up was 48 mo [interquartile range(IQR):38-52].Three patients were lost to follow-up.In 44% of patients retreatment was done after a median of 4 mo(IQR:3-8).No serious adverse events occurred.At the end of follow-up,symptom scores and4 out of 6 QoL subscales were improved(all P < 0.01compared to baseline).However,80% of patients required PPIs for their GERD symptoms.Ultimately,64% of patients were classified as treatment failures.In 60% a post-procedural endoscopy was carried out,of which in 16% reflux esophagitis was diagnosed.CONCLUSION:In the 4-year follow-up period,the subset of GERD patients that benefit from endoscopic gastroplication kept declining gradually,nearly half opted for retreatment and 80% required PPIs eventually. | Matthijs P Schwartz J Rieneke C Schreinemakers André J P M Smout | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013,4,4: | 4 |
| 3 | Early and sufhcient feeding reduces length of stay and charges in surgical patients显示文摘 | Neumayer LA Smout R J Horn HG | 2001 | J Surg Res2001,95,: | 1 |
| 4 | Emerging therapies for GERD 显示文摘 | Vander-Pol R Benninga M A Smout A J | 2011 | J Pediatr Gastroenterol Nutr2011,53,2: | 1 |
| 5 | Reverse transcriptase activity and untranslated region sharing of a new RTE-like, non-long terminal repeat retrotransposon from the human blood fluke, Schistosoma japonicum显示文摘 | Laha T Brindley PJ Smout M J | 2002 | Int J Parasitol2002,32,9: | 1 |
| 6 | High-resolution manometry显示文摘 | BREDENOORD A J SMOUT A J | 2008 | Dig Liver Dis2008,40,: | 1 |
| 7 | Early and sufficient feeding reduces length of stay and charges in surgical patients 显示文摘 | Neumayer LA Smout R J Horn HG | 2001 | J Surg Res2001,95,: | 1 |
| 8 | Isolation of cDNAs encoding secreted and transmembrane proteins from Schistosoma mansoni by a sig- nal sequence trap method 显示文摘 | Smyth D McManus DP Smout M J | 2003 | Infect Immun2003,71,5: | 1 |
| 9 | Supmesophageal manifestations of gastroeso - phageal reflux disease显示文摘 | Groen J N Smout A J | 2003 | Eur J Gastroenteml Hepatol2003,15,: | 1 |
| 10 | Effect of different recumbent positions on postprandial gastroesophageal reflux in normal subjects显示文摘 | Herwaarden MA Katzka DA Smout A J | 2000 | Am J Gastroenterol2000,95,10: | 1 |
| 11 | PPI therapy is equally effective in well-defined non-erosive reflux disease and in reflux esophagitis: a meta-analysis 显示文摘 | Weijenborg PW Cremonini F Smout A J | 2012 | Neurogastroenterol Motil2012,24,8: | 1 |
| 12 | Aspirin resistance显示文摘 | Smout J Stansby G | 2002 | Br J Surg2002,89,1: | 1 |
| 13 | Chemospecific alterations in duodenal perception and motor response in functional dyspepsia显示文摘 | Schwartz M P Samsom M Smout A J | 2001 | Am J Gastroenterol2001,96,9: | 1 |
| 14 | High-resolution manometry 显示文摘 | Bredenoord A J Smout AJ | 2008 | Dig Liver Dis2008,40,3: | 1 |
| 15 | Gastro-oesophageal reflux disease显示文摘 | Albert J Bredenoord John E Pandolfino André JPM Smout | 2013 | The Lancet . 2013 (9881)2013,,: | 1 |
| 16 | Chronic consti pation and rectal functional investigations 显示文摘 | De Schepper H U Bredenoord A J Smout A J | 2013 | Ned Tijdschr Geneeskd2013,157,8: | 1 |
| 17 | Role of electrogastrography and gastric impedance measurements in evalauation of gastric emptying and motility 显示文摘 | Smout A J Jebbink HJ Akkermans LM | 1994 | Dig Dis Sci1994,39,12: | 1 |
| 18 | Refractory gastrooesophageal reflux disease显示文摘 | Bredenoord A J Smout AJ | 2008 | Eur J Gastroenterol Hepatol2008,20,: | 1 |
| 19 | Platelet function following acute cerebral ischemia显示文摘 | SMOUT J DYKER A CLEANTHIS M | 2009 | Angiology2009,60,3: | 1 |
| 20 | Distal esophageal spasm evolving to achalasia in high resolution显示文摘 | De Schepper HU Smout A J Bredenoord AJ | 2014 | Clin Gastroen- terol Hepatal2014,12,2: | 1 |