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| 1 | Real-time intelligent big data processing:technology, platform, and applications显示文摘Human beings keep exploring the physical space using information means. Only recently, with the rapid development of information technologies and the increasing accumulation of data, human beings can learn more about the unknown world with data-driven methods. Given data timeliness, there is a growing awareness of the importance of real-time data. There are two categories of technologies accounting for data processing: batching big data and streaming processing, which have not been integrated well. Thus,we propose an innovative incremental processing technology named after Stream Cube to process both big data and stream data. Also, we implement a real-time intelligent data processing system, which is based on real-time acquisition, real-time processing, real-time analysis, and real-time decision-making. The real-time intelligent data processing technology system is equipped with a batching big data platform, data analysis tools, and machine learning models. Based on our applications and analysis, the real-time intelligent data processing system is a crucial solution to the problems of the national society and economy. | Tongya ZHENG Gang CHEN Xinyu WANG Chun CHEN Xingen WANG Sihui LUO | 2019 | Science China(Information Sciences)2019，62，8： | 8 |
| 2 | Numerical simulation of wellbore and formation temperature fields in carbonate formations during drilling and shut-in in the presence of lost circulation显示文摘Temperature curves reflect geothermal gradients and local temperature anomalies, thus providing a new understanding of the underground reservoir conditions. When encountering caverns or fractures and fissures during drilling, lost circulation may occur and result in a change to the original formation temperature field, and in severe cases, even the conventional open hole well logging data cannot be obtained. This paper uses finite element analysis software COMSOL to establish a heat transfer model for the wellbore/reservoir formation system during drilling and shut-in in the presence of lost circulation, and a case study is made in a carbonate reservoir in the Tahe oilfield. On the basis of the above, we analyze the temperature distribution in the leakage zone, and the studies have shown that the leakage and petrophysical properties have an impact on the temperature of the wellbore and formation, hence we can estimate the reservoir permeability using the temperature data. In addition, the determination of the temperature recovery time after some drilling fluids have leaked into the formation will help in recognizing the subsurface temperature field of the carbonate formation correctly, thus enhancing production logging interpretation accuracy and improving the understanding of later measurements. | Pan Baozhi Li Ding Chen Gang Wang Qincong Ma Lixin Liu Sihui | 2014 | Petroleum Science2014，11，2： | 3 |
| 3 | Inflection point: a perspective on photonic nanojets显示文摘When light propagates through the edge or middle part of a microparticle’s incoming interface,there is a basic rule that light converges and diverges rapidly or slowly at the output port. These two parts are referred to as the region of rapid change (RRC) and region of slow change (RSC),respectively. Finding the boundary point between RRC and RSC is the key to reveal and expound upon this rule scientifically. Based on the correlation between light convergence–divergence and the slope of emergent light,combined with the relationship between a natural logarithm and growth in physical reality and the second derivative of a function in practical significance,we determine the boundary point between RRC and RSC,namely,the inflection point. From such a perspective,a photonic nanojet (PNJ) and near-field focusing by light irradiation on RSC and RRC,as well as the position of the inflection point under different refractive index contrasts and the field distribution of light focusing,are studied with finite-element-method-based numerical simulation and ray-optics-based theoretical analysis. By illuminating light of different field intensity ratios to the regions divided by the inflection point,we demonstrate the generation of a photonic hook (PH) and the modulation of PNJ/PH in a new manner. | GUOQIANG GU PENGCHENG ZHANG SIHUI CHEN YI ZHANG HUI YANG | 2021 | Photonics Research2021，9，7： | 2 |
| 4 | Real-time monitoring of optimum timing for harvesting fresh tea leaves based on machine vision显示文摘The harvesting time of fresh tea leaves has a significant impact on product yield and quality.The aim of this study was to propose a method for real-time monitoring of the optimum harvesting time for picking fresh tea leaves based on machine vision.Firstly,the shapes of fresh tea leaves were distinguished from RGB images of the tea-tree canopy after graying with the improved B-G algorithm,filtering with a median filter algorithm,binary processing with the Otsu algorithm,and noise reduction and edge smoothing using open and close operations.Then the leaf characteristics,such as leaf area index,average length,and leaf identification index,were calculated.Based on these,the Bayesian discriminant principle and method were used to construct a discriminant model for fresh tea-leaf collection status.When this method was applied to a RGB tea-tree canopy image acquired at 45°shooting angle,the fresh tea-leaf recognition rate was 90.3%,and the accuracy for fresh tea-leaf harvesting status was 98%by cross validation.Hence,this method provides the basic conditions for future tea-plantation operation and management using information technology,automation,and intelligent systems. | Liang Zhang Hongduo Zhang Yedong Chen Sihui Dai Xumeng Li Kenji Imou Zhonghua Liu Ming Li | 2019 | International Journal of Agricultural and Biological Engineering2019，12，1： | 2 |
| 5 | The Optimization of Ultrasonic-assisted Extraction of Polysaccharide from Sipunculus nudus by Response Surface Methodology and Study on Antioxidant Activity显示文摘[Objectives]This study was conducted to optimize the extraction process of Sipunculus nudus polysaccharide and study the antioxidant activity of S. nudus polysaccharide. [Methods] S. nudus polysaccharide was extracted by ultrasonic microwave assisted method,during which univariate factors including solidliquid ratio,time,temperature,ultrasonic power,microwave power were investigated,to select optimal extracting conditions,which were also verified by an response surface optimization experiment( an four-factor three-level test); and the antioxidant activity of S. nudus polysaccharide was studied by determining its DPPH radical scavenging capacity. [Results]Through univariate factor investigation and response surface optimization test,it was found that the response surface results were consistent with univariate results. The optimized conditions were as follows: solid-liquid ratio at 1∶ 15,ultrasonic temperature at 60 ℃,ultrasonic power of 360 W and microwave power of 200 W,and the predicted polysaccharide extracting amount was 4. 35 mg/g. Under the optimized extracting conditions,the average extracting amount of S. nudus polysaccharide was 4. 38 mg/g,which is close to the theoretical predicted value( 4. 35 mg/g). And the results of this study also showed that different concentrations of polysaccharide solutions have different scavenging effects on DPPH free radical. At the polysaccharide concentration of0. 16 mg/ml,the maximum value of DPPH radical scavenging rate was 7. 22%,indicating that polysaccharide has certain antioxidant capacity. [Conclusions]This method is a new trial with satisfactory results. | Wen CHEN Xiangjun WANG Yujie WANG Sihui LIU Jiahui WEN Ruzheng CAI Weiqiang LIU Liuhuan LI | 2019 | Agricultural Biotechnology2019，8，1： | 2 |
| 6 | Population Genetics of SARS-CoV-2: Disentangling Effects of Sampling Bias and Infection Clusters显示文摘A novel RNA virus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is responsible for the ongoing outbreak of coronavirus disease 2019(COVID-19).Population genetic analysis could be useful for investigating the origin and evolutionary dynamics of COVID-19.However,due to extensive sampling bias and existence of infection clusters during the epidemic spread,direct applications of existing approaches can lead to biased parameter estimations and data misinterpretation.In this study,we first present robust estimator for the time to the most recent common ancestor(TMRCA)and the mutation rate,and then apply the approach to analyze 12,909 genomic sequences of SARS-CoV-2.The mutation rate is inferred to be 8.69×10^(−4) per site per year with a 95%confidence interval(CI)of[8.61×10^(−4),8.77×10^(−4)],and the TMRCA of the samples inferred to be Nov 28,2019 with a 95%CI of[Oct 20,2019,Dec 9,2019].The results indicate that COVID-19 might originate earlier than and outside of Wuhan Seafood Market.We further demonstrate that genetic polymorphism patterns,including the enrichment of specific haplotypes and the temporal allele frequency trajectories generated from infection clusters,are similar to those caused by evolutionary forces such as natural selection.Our results show that population genetic methods need to be developed to efficiently detangle the effects of sampling bias and infection clusters to gain insights into the evolutionary mechanism of SARS-CoV-2.Software for implementing VirusMuT can be downloaded at http://gffzzdbc7b6aaae734bddswqckkvx6fn9v6po6.ffgz.tsg.suse.edu.cn/biocode/tools/BT007081. | Qi Liu Shilei Zhao Cheng-Min Shi Shuhui Song Sihui Zhu Yankai Su Wenming Zhao Mingkun Li Yiming Bao Yongbiao Xue Hua Chen | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 1 |
| 7 | cGAS guards against chromosome endto-end fusions during mitosis and facilitates replicative senescence显示文摘As a sensor of cytosolic DNA, the role of cyclic GMP-AMP synthase (cGAS) in innate immune response is well established, yet how its functions in different biological conditions remain to be elucidated. Here, we identify cGAS as an essential regulator in inhibiting mitotic DNA double-strand break (DSB) repair and protecting short telomeres from end-to-end fusion independent of the canonical cGAS-STING pathway. cGAS associates with telomeric/subtelomeric DNA during mitosis when TRF1/TRF2/POT1 are deficient on telomeres. Depletion of cGAS leads to mitotic chromosome end-to-end fusions predominantly occurring between short telomeres. Mechanistically, cGAS interacts with CDK1 and positions them to chromosome ends. Thus, CDK1 inhibits mitotic non-homologous end joining (NHEJ) by blocking the recruitment of RNF8. cGAS-deficient human primary cells are defective in entering replicative senescence and display chromosome end-to-end fusions, genome instability and prolonged growth arrest. Altogether, cGAS safeguards genome stability by controlling mitotic DSB repair to inhibit mitotic chromosome end-to-end fusions, thus facilitating replicative senescence. | Xiaocui Li Xiaojuan Li Chen Xie Sihui Cai Mengqiu Li Heping Jin Shu Wu Jun Cui Haiying Liu Yong Zhao | 2022 | Protein & Cell2022，13，1： | 1 |
| 8 | 显示文摘 | Sihui Zhan Dairong Chen Xiuling Jiao Caihong Tao | 2006 | Journal of Physical Chemistry B2006，110，11： | 1 |
| 9 | Primate embryonic stem cells create their own niche while differentiating in three-dimensional culture systems显示文摘 | Michelini M Franceschini V Sihui Chen S | 2006 | Cell Prolif2006，39，3： | 1 |
| 10 | Facile fabrication of long α-Fe2 O3 , α -Fe and γ -Fe2 O3 hollow fibers using sol- gel combined co-electrospinning technology 显示文摘 | Zhan Sihui Chen Dairong Jiao Xiuling | 2007 | J Colloid In- terface Sci2007，308，1： | 1 |
| 11 | The zinc finger transcription factor,KLF2,protects against COVID-19 associated endothelial dysfunction显示文摘Coronavirus disease 2019(COVID-19)is regarded as an endothelial disease(endothelialitis)with its patho-mechanism being incompletely understood.Emerging evidence has demonstrated that endothelial dysfunction precipitates COVID-19 and its accompanying multi-organ injuries.Thus,pharmacotherapies targeting endothelial dysfunction have potential to ameliorate COVID-19 and its cardiovascular complications.The objective of the present study is to evaluate whether kruppel-like factor 2(KLF2),a master regulator of vascular homeostasis,represents a therapeutic target for C0VID-19-induced endothelial dysfunction.Here,we demonstrate that the expression of KLF2 was reduced and monocyte adhesion was increased in endothelial cells treated with COVID-19 patient serum due to elevated levels of pro-adhesive molecules,ICAM1 and VCAM1.IL-1β and TNF-α;two cytokines elevated in cytokine release syndrome in COVID-19 patients,decreased KLF2 gene expression.Pharmacologic(atorvastatin and tannic acid)and genetic(adenoviral overexpression)approaches to augment KLF2 levels attenuated COVID-19-serum-induced increase in endothelial inflammation and monocyte adhesion.Next-generation RNA-sequencing data showed that atorvastatin treatment leads to a cardiovascular protective transcriptome associated with improved endothelial function(vasodilation,antiinflammation,antioxidant status,anti-thrombosis/-coagulation,anti-fibrosis,and reduced angiogenesis).Finally,knockdown of KLF2 partially reversed the ameliorative effect of atorvastatin on COVID-19-serum-induced endothelial inflammation and monocyte adhesion.Collectively,the present study implicates loss of KLF2 as an important molecular event in the development of COVID-19-induced vascular disease and suggests that efforts to augment KLF2 levels may be therapeutically beneficial. | Suowen Xu Yujie Liu Yu Ding Sihui Luo Xueying Zheng Xiumei Wu Zhenghong Liu Iqra Ilyas Suyu Chen Shuxin Han Peter J.Little Mukesh K.Jain Jianping Weng | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 1 |
| 12 | Preparation of ZnFe2O4 nanofibers by sol-gel related eleetrospinning method 显示文摘 | Zhan Sihui Gong Cairong Chen Dairong | 2006 | J Disper Sei Techn2006，27，7： | 1 |
| 13 | Long TiO2 hollow fibers with mesoporous walls: Sol-gel combined electrospun fabrication and photoeatalytie properties显示文摘 | Zhan Sihui Chen Dairong Jiao Xiuling | 2006 | J Phys Chem B2006，110，11： | 1 |
| 14 | Facile fabrication of long alpha-Fe2O3, alpha-Fe and gamma-Fe2O3 hollow fibers using sol-gel combined co-electrospinning technology显示文摘 | Zhan Sihui Chen Dairong Jiao Xiuling | 2007 | J Colloid Interf Sci2007，308，1： | 1 |
| 15 | Co-electrospun SiO2 hollow nanostructured fibers with hierarchical walls显示文摘 | Zhan Sihui Chen Dairong Jiao Xiuling | 2008 | J Colloid Interf Sci2008，318，2： | 1 |
| 16 | Facile fabrication of long α -Fe 2 O 3 , α -Fe and γ -Fe 2 O 3 hollow fibers using sol–gel combined co-electrospinning technology显示文摘 | Sihui Zhan Dairong Chen Xiuling Jiao Shusheng Liu | 2006 | Journal of Colloid And Interface Science2006，，1： | 1 |
| 17 | A general strategy to the synthesis of carbon-supported PdM(M=Co,Fe and Ni)nanodendrites as high-performance electrocatalysts for formic acid oxidation显示文摘Rational synthesis of a new class of electrocatalysts with high-performance and low-cost is of great significance for future fuel cell devices. Herein, we demonstrate a general one-step simultaneous reduction method to prepare carbon-supported Pd M(M = Co, Fe, Ni) alloyed nanodendrites with the assistance of oleylamine and octadecylene. The morphology, structure and composition of the obtained Pd M nanodendrites/C catalysts have been fully characterized. The combination of the dendritic structural feature and alloyed synergy offer higher atomic utilization efficiency, excellent catalytic activity and enhanced stability for the formic acid oxidation reaction(FAOR). Strikingly, the as-synthesized Pd Co nanodendrites/C catalyst could afford a mass current density of 2467.7 A g^(-1), which is almost 3.53 and 10.4 times higher than those of lab-made Pd/C sample(698.3 A g^(-1)) and commercial Pd/C catalyst(237.6 A g^(-1)), respectively. Furthermore, the PdC o nanodendrites/C catalyst also exhibit superior stability relative to the Pd/C catalysts, make it a promising anodic electrocatalyst in practical fuel cells in the future. Additionally, the present feasible synthetic approach is anticipated to provide a versatile strategy toward the preparation of other metal alloy nanodendrites/carbon nanohybrids. | Yanrong Ma Tongfei Li Hao Chen Xiaojie Chen Sihui Deng Lin Xu Dongmei Sun Yawen Tang | 2017 | Journal of Energy Chemistry2017，26，6： | 1 |
| 18 | Optofluidics in bio-imaging applications显示文摘Bio-imaging generally indicates imaging techniques that acquire biological information from living forms.Recently, the ability to detect, diagnose, and monitor pathological, physiological, and molecular dynamics is in great demand, while scaling down the observing angle, achieving precise alignment, fast actuation, and a miniaturized platform become key elements in next-generation optical imaging systems. Optofluidics, nominally merging optic and microfluidic technologies, is a relatively new research field, and it has drawn great attention since the last decade. Given its abilities to manipulate both optic and fluidic functions/elements in the micro-/nanometer regime, optofluidics shows great potential in bio-imaging to elevate our cognition in the subcellular and/or molecular level. In this paper, we emphasize the development of optofluidics in bio-imaging, from individual components to representative applications in a more modularized, systematic sense. Further, we expound our expectations for the near future of the optofluidic imaging discipline. | SIHUI CHEN RUI HAO YI ZHANG HUI YANG | 2019 | Photonics Research2019，7，5： | 1 |
| 19 | The Identification of Phenylalanine Ammonia-Lyase(PAL)Genes from Pinus yunnanensis and an Analysis of Enzyme Activity in vitro显示文摘Phenylalanine ammonia lyase(PAL)is the rate-limiting and pivotal enzyme of the general phenylpropanoid path-way,but few reports have been found on PAL genes in Pinus yunnanensis.In the present study,three PAL genes were cloned and identified from P.yunnanensis seedlings for thefirst time,namely,PyPAL-1,PyPAL-2,and PyPAL-3.Our results indicated that the open-reading frames of PyPAL genes were 2184,2157,and 2385 bp.Phylogenetic tree analysis revealed that PyPALs have high homology with other known PAL genes in other plants.In vitro enzymatic analysis showed that all three PyPAL recombinant proteins could catalyze the deamination of L-phenylalanine to form trans-cinnamic acid,but only PAL1 and PAL2 can catalyze the conversion of L-tyrosine toρ-coumaric acid.Three PyPAL genes were expressed in different tissues in 1-year-old P.yunnanensis,and such genes had different expression patterns.This study lays a foundation for further understanding of the biosynthesis of secondary metabolites in P.yunnanensis. | Dejin Mu Lin Chen Heze Wang Zhaoliu Hu Sihui Chen Shi Chen Nianhui Cai Yulan Xu Junrong Tang | 2024 | Phyton-International Journal of Experimental Botany2024，93，3： | 0 |
| 20 | Rational design, synthesis and prospect of biodegradable magnesium alloy vascular stents显示文摘Biodegradable magnesium(Mg) alloys are expected to be promising materials for cardiovascular stents(CVS), which can avoid the longterm clinical problems of current CVS, such as in-stent restenosis, late stent thrombosis, etc. Mg alloy stents exhibit superior biocompatibility and tunable biodegradability, compared with conventional permanent metallic stents. However, the poor formability and non-uniform corrosion of Mg alloy stents hinder their clinical application of CVS. This review focuses on the development of Mg alloys for CVS in recent years.According to the results of bibliometric analysis, we analyzed different biodegradable Mg alloy systems. Moreover, the structural design strategies for Mg alloy stents that can reduce the stress concentration, as well as the surface modification methods to control the corrosion behavior and biological performance of Mg alloy stents are also highlighted. At last, this review systematically discussed the potential directions and challenges of biodegradable magnesium stents(BMgS) in cardiovascular fields. | Senwei Wang Chengao Du Xin Shen Xiong Wu Sihui Ouyang Jun Tan Jia She Aitao Tang Xianhua Chen Fusheng Pan | 2023 | Journal of Magnesium and Alloys2023，11，9： | 0 |
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