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| 1 | Comprehensive lipidomics in apoM^(-/-) mice reveals an overall state of metabolic distress and attenuated hepatic lipid secretion into the circulation显示文摘Apolipoprotein M(apoM) participates in both high-density lipoprotein and cholesterol metabolism. Little is known about how apo M affects lipid composition of the liver and serum. In this study, we systemically investigated the effects of apo M on liver and plasma lipidomes and how apo M participates in lipid cycling, via apo M knockout in mice and the human SMMC-7721 cell line. We used integrated mass spectrometry-based lipidomics approaches to semiquantify more than 600 lipid species from various lipid classes, which include free fatty acids, glycerolipids, phospholipids, sphingolipids, glycosphingolipids, cholesterol, and cholesteryl esters(CEs), in apo M^(-/-)mouse. Hepatic accumulation of neutral lipids, including CEs, triacylglycerols, and diacylglycerols, was observed in apo M^(-/-)mice;while serum lipidomic analyses showed that, in contrast to the liver, the overall levels of CEs and saturated/monounsaturated fatty acids were markedly diminished. Furthermore, the level of Apo B-100 was dramatically increased in the liver, whereas significant reductions in both Apo B-100 and low-density lipoprotein(LDL) cholesterol were observed in the serum of apo M^(-/-)mice, which indicated attenuated hepatic LDL secretion into the circulation. Lipid profiles and proinflammatory cytokine levels indicated that apo M^(-/-)leads to hepatic steatosis and an overall state of metabolic distress. Taken together, these results revealed that apo M knockout leads to hepatic steatosis, impaired lipid secretion, and an overall state of metabolic distress. | Yuanping Shi Sin Man Lam Hong Liu Guanghua Luo Jun Zhang Shuang Yao Jie Li Lu Zheng Ning Xu Xiaoying Zhang Guanghou Shui | 2020 | Journal of Genetics and Genomics2020，47，9： | 2 |
| 2 | Effects of keratinocyte growth factor on the proliferation and radiation survival of human squamous cell carcinoma cell lines in vitro and in vivo 显示文摘 | Ning S Shui C Khan WB | 1998 | Int J Radiat Biol Phys1998，0，1： | 1 |
| 3 | Enhancement of murine intestinal stem ce ll surival after irradiation by keratinocyte growth factor radiation显示文摘 | Khan BW Shui C Ning S | 1997 | Radiate Res1997，248，： | 1 |
| 4 | Aerial Silk Road Soars The“Silk Road in the Air”promoted by China Eastern Airlines will reach around the world to bring people in BRI partner countries even closer together显示文摘Two thousand years ago,the Silk Road connecting Xi’an to Rome was a long journey that took more than a year.Today,China Eastern Airlines makes the journey in just over 10 hours with the world’s most advanced wide-body airliner.The power of civil aviation has made the Silk Road more convenient than ever before.Over the last decade of the Belt and Road Initiative(BRI),the“Aerial Silk Road”has connected more and more destinations around the world. | Shui Ning Song Mengfei | 2024 | China Report ASEAN2024，9，1： | 0 |
| 5 | Viscosity properties and strong liquid behavior of Pr_(60)Ni_(25)Al_(15) bulk metallic glass-forming liquids显示文摘Pr60Ni25Al15 bulk metallic glass in a cuboid form with dimensions of 2 mm×2 mm×55 mm by copper mold casting method was cast. The dynamic viscosity near the glass transition region for Pr60Ni25Al15 was measured by three-point beam bending methods. The fragility parameter m and activation energy for viscous flow of the liquid sample were calculated to be:m=31.66,E=10689.17 K,respectively. It was shown that the supercooled liquid of Pr60Ni25Al15 alloy behaved much closer to strong glasses. The variation of active energy with temperature in supercooled liquid was analyzed. It was found that Kivelson’s super-Arrhenius equation is not suitable for description of the activation energy in a supercooled region of Bulk metallic glass,and there is a direct proportion between activation energy crystal-lization and activation energy of viscous flow. | WANG Dan,ZHANG Di,WANG ShuYing,NING QianYan,ZHENG CaiPing,YAN Yuan,LIU Jia & SUN MinHua Department of Physics,Harbin Normal University,Harbin 150025,China | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，3： | 0 |
| 6 | China Eastern Airlines:Shouldering More Responsibilities显示文摘SINCE the 18th National Congress of the Communist Party of China(CPC)in 2012,China Eastern Airlines Group has pursued high-quality development and played a leading role in China’s civil aviation.From energy conservation and carbon reduction,to airborne evacuation missions and public welfare charity,China Eastern is committed to fulfilling its social responsibilities commitments as a leading enterprise. | SHUI NING | 2022 | China Today2022，71，12： | 0 |
| 7 | Proteomics Analysis of T Lymphocytes Damage Induced by Ionizing Irradiation显示文摘T 淋巴细胞被发现是包括 apoptosis 的高度对射线敏感、复杂的细胞的回答的人能在暴露之上被导致到 X 光检查照耀。然而,与照耀联系的 apoptosis 的机制不是清楚的。在这研究,一个 proteomic 方法在照耀以后在人的 T 淋巴细胞房间的 proteome 的改变上被用于调查。Jurkat 房间与 4 Gy X 光检查被照耀,房间 lysates 在在照耀(6, 12, 18, 24 和 48 h ) 以后的不同时间是镇定的。整个蛋白质被二维的荧光差别胶化电气泳动,然后差别分开并且确定表示蛋白质被集体 spectrometry 识别。4 蛋白质在丰富展出了重要导致照耀的差别,包括 L-plastin, bifunctional 嘌呤生合成蛋白质,导管素贝它链,贝它肌动朊。差别表示了蛋白质向被汇报直接或间接地涉及人的 T 淋巴细胞的功能。因此,这研究可能提供线索与与照耀有关的生物意义识别蛋白质。 | Shi, Ying Zhang, Xuan Liu, Ning Liang, Feng Song, Fengrui Liu, Zhiqiang Liu, Shuying | 2011 | Chinese Journal of Chemistry2011，29，1： | 0 |
| 8 | System Dynamics and Airlines' Economic Operation Model | WU Tong\|shui\+1,\ QIN Jing\+2,\ NING Xuan\|xi\+2 1.Civil Aviation University of China, Tianjin 300300, China 2.Business And Management College, NUAA Nanjing 210016, China | 2000 | Systems Science and Systems Engineering2000，10，1： | 0 |
| 9 | Optical soliton in a one-dimensional array of a metal nanoparticle-microcavity complex显示文摘Quantum coherence can be enhanced by placing metal nanoparticles(MNPs)in optical microcavities.Combining localized-surface plasmon resonances(LSPRs),nonlinear interaction between the LSPR and microcavity arrays of a MNP-microcavity complex offer a unique playground to observe novel optical phenomena and develop novel concepts for quantum manipulation.Here we theoretically demonstrate that optical solitons are achievable with a one-dimensional array which consists of a chain of periodically spaced identical MNP-microcavity complex systems.These differ from the solitons which stem from the MNPs with nonlinear Kerr-like response;the optical soliton here originates from LSPR-microcavity interaction.Using experimentally achievable parameters,we identify the conditions under which the nonlinearity induced by LSPR-microcavity interaction allows us to compensate for the dispersion caused by photon hopping of adjacent microcavities.More interestingly,the dynamics of solitons can be modulated by varying the radius of the MNP.The presented results illustrate the potential to utilize the MNP-microcavity complex for light manipulation,as well as to guide the design of photon switch and on-chip photon architecture. | Ning Ji Tao Shui Yi-Lou Liu Wang-Rui Zhang Xiu-Mei Chen Wen-Xing Yang | 2021 | Communications in Theoretical Physics2021，73，11： | 0 |
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