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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Dynamics of total culturable bacteria and its relationship with methylmercury in the soils of the water level fluctuation zone of the Three Gorges Reservoir显示文摘Field investigations were conducted to study the temporal and spatial distribution characteristics of total culturable bacteria(TCB)and its relationship with methylmercury(MeHg)in the soils of the water level fluctuation zone of the Three Gorges Reservoir.Different altitudes(170–180,170–175,165–170 and 160–165 m)in Zhenxi(Site 1),Shibaozhai(Site 2)and Tujing(Site 3),Chongqing,China were chosen as sampling sites.Results indicated that TCB did not have significant difference in the top(0–10 cm)and sub(10–20 cm)soil of the non-inundated area(175–180 m),but showing a significant difference in the water level fluctuation zone(\175 m,suggesting that water level fluctuation had an important effect on TCB.Moreover,TCB in soils of various altitudes of Site 1 and 2had significant difference,while for Site 3,this difference was not significant.And the difference of TCB in Site 2was much greater than that in Site 1.These results suggested that there were significant differences for TCB in soils of mainstream and tributaries.In addition,TCB in soils of 10–20 cm had significant or highly significant positive correlations with MeHg level(r C 0.762,P B 0.048),thus we assumed that there may be some aerobic microorganisms playing dominant roles in mercury methylation. | Yuping Xiang Hongxia Du Hong Shen Cheng Zhang Dingyong Wang | 2014 | Chinese Science Bulletin2014，59，24： | 10 |
| 3 | A hybrid quantum-based PIO algorithm for global numerical optimization显示文摘A novel hybrid quantum-based pigeon-inspired optimization(PIO) algorithm for global numerical optimization is proposed to perceive deceptiveness and preserve diversity. In the proposed algorithm,the current best solution is regarded as a linear superposition of two probabilistic states, namely positive and deceptive. Through a quantum rotation gate, the positive probability is either enhanced or reset to balance exploration and exploitation. Simulation results reveal that the hybrid quantum-based PIO algorithm demonstrates an outstanding performance in global optimization owing to preserving diversity in the early evolution. As a result, the stability of the algorithm is enhanced so that the precision of optimization is improved statistically. The proposed algorithm is demonstrated to be effective for solving multimodal and non-convex problems in higher dimension with a smaller population size. | Boyi CHEN Hao LEI Haidong SHEN Yanbin LIU Yuping LU | 2019 | Science China(Information Sciences)2019，62，7： | 7 |
| 4 | Modal identification based on Hilbert-Huang Transform of structural response with S VD preprocessing显示文摘In recent years, Empirical mode decompositionand Hilbert spectral analysis have been combined to identifysystem parameters. Singular-Value Decomposition is proposedas a signal preprocessing technique of Hilbert-HuangTransform to extract modal parameters for closely spacedmodes and low-energy components. The proposed methodis applied to a simulated airplane model built in AutomaticDynamic Analysis of Mechanical Systems software. Theresults demonstrate that the identified modal parameters arein good agreement with the baseline model. | Min Zheng Fan Shen Yuping Dou Xiaoyan Yan College of Civil Aviation,Nanjing University of Aeronautics and Astronautics,210016 Nanjing. China | 2009 | Acta Mechanica Sinica2009，25，6： | 7 |
| 5 | Epigenetic control on cell fate choice in neural stem cells显示文摘Derived from neural stem cells(NSCs)and progenitor cells originated from the neuroectoderm,the nervous system presents an unprecedented degree of cellular diversity,interwoven to ensure correct connections for propagating information and responding to environ-mental cues.NSCs and progenitor cells must integrate cell-intrinsic programs and environmental cues to achieve production of appropriate types of neurons and glia at appropriate times and places during develop-ment.These developmental dynamics are reflected in changes in gene expression,which is regulated by transcription factors and at the epigenetic level.From early commitment of neural lineage to functional plas-ticity in terminal differentiated neurons,epigenetic regulation is involved in every step of neural develop-ment.Here we focus on the recent advance in our un-derstanding of epigenetic regulation on orderly genera-tion of diverse neural cell types in the mammalian nervous system,an important aspect of neural devel-opment and regenerative medicine. | Xiao-Ling Hu Yuping Wang Qin Shen | 2012 | Protein & Cell2012，3，4： | 5 |
| 6 | U-Pb dating of zircon grains from the ore-bearing plagioclase amphibolite in the Dashuigou Te deposit显示文摘The Dashuigou Te deposit is a unique independent one found in the world, and hosted in the plagioclase amphibolite. The upper intercept age of single zircon from the amphibolite can be considered to be the crystallization age of the source-rock of the amphibolite (tholeiitic basalt), while the lower intercept is nearly consistent with the time of the tectono-thermal event. | Shijin Xu Weizhou Shen Rucheng Wang Jianjun Lu Xiaoming Chen Yuping Lin | 1998 | Chinese Science Bulletin1998，43，17： | 5 |
| 7 | Performance limitations in trajectory tracking control for air-breathing hypersonic vehicles显示文摘An integrated approach that considers the performance limitations of tracking control systems for air-breathing hypersonic vehicles is proposed. First, a set of ascent trajectories is obtained as candidates for tracking control through a trajectory design method that considers the available acceleration. Second, the basic theory of performance limitations, which is adopted to calculate the limits on control performance through the trajectory, is integrated. The openloop dynamics of air-breathing hypersonic vehicles is responsible for these limits on the control system. Comprehensive specifications on stability, tracking accuracy, and robustness are derived, and the flight envelope with constraints and control specifications is identified. Simulation results suggest that trajectory design should consider restrictions on control performance to obtain reliable solutions. | Boyi CHEN Yanbin LIU Haidong SHEN Hao LEI Yuping LU | 2019 | Chinese Journal of Aeronautics2019，32，1： | 4 |
| 8 | 0.5981μm Sum Frequency Mixing in KTP Crystal显示文摘Based on accurate values of refractive indices,the phase matching angles(θ_(m))and effective nonlinear coeficients(d_(eff))for type I and I I sum frequency mixing of 1.0795 and 1.3414μm radiations were calculated in KTP crystal.The optimum phase matching conditions are thatθm=75.74o in the XZ plane(Ф=0)and deff=17.42 × 10^(-9) esu.The calculated results agree well with the experimental results.Thus,the cw 0.5981μm sum frequency radiation was achieved in KTP crystal using a 1.0795 and 1.3414μm double-wavelength Nd:YAP cw laser. | SHEN Hongyuan ZHOU Yuping LIN Wenxiong ZENG Ruirong YU Guifang HUANG Chenghui ZENG Zhengdong ZHANG Weijia JIA Shouquan JIANG Peizhi XIAO Chaoliang | 1991 | Chinese Physics Letters1991，8，4： | 2 |
| 9 | Water level fluctuations influence microbial communities and mercury methylation in soils in the Three Gorges Reservoir,China显示文摘Reservoirs tend to have enhanced methylmercury(MeHg) concentrations compared to natural lakes and rivers, and water level fluctuations can promote MeHg production. Until now, little research has been conducted on the effects of microorganisms in soils for the formation of MeHg during different drying and flooding alternating conditions in the Three Gorges Reservoir(TGR). This study aimed to understand how water level fluctuations affect soil microbial composition and mercury concentrations, and if such microbial variations are related to Hg methylation. The results showed that MeHg concentrations and the ratios of MeHg to THg(MeHg%) in soils were higher in the seasonally drying and flooding alternating areas(DFAs, 175–155 m) than those in the non-inundated(NIAs, > 175 m) and inundated areas(IAs, < 145 m). However, MeHg% in all samples was less than 1%, indicating that the Hg methylation activity in the soils of the TGR was under a low level. 454 highthroughput sequencing of 16 S rRNA gene amplicons showed that soil bacterial abundance and diversity were relatively higher in DFA compared to those in NIA and IA, and microbial community composition varied in these three areas. At the family level, those groups in Deltaproteobacteria and Methanomicrobia that might have many Hg methylators were also showed a higher relative abundance in DFA, which might be the reason for the higher MeHg production in these areas. Overall, our results suggested that seasonally water level fluctuations can enhance the microbial abundance and diversity, as well as MeHg production in the TGR. | Yuping Xiang Yongmin Wang Cheng Zhang Hong Shen Dingyong Wang | 2018 | Journal of Environmental Sciences2018，30，6： | 2 |
| 10 | Effect of Zibushenjing Fang on skeletal development and brain tissue antioxidation in mice with kidney essence insufficiency: a mechanistic study显示文摘OBJECTIVE: To investigate the effects of Zibushenjing Fang (formula for tonifying the kidney essence) on skeletal development and brain tissue antioxidation in mice with kidney essence insufficiency. METHODS: Fifty male Kunming mice were randomly divided into five groups: normal group, model group, Jinkuishenqi Wan group, Zibushenjing Fang high dose group, and Zibushenjing Fang low dose group, with 10 mice in each group. The model of kidney essence insufficiency syndrome was established in all the mice except the normal group by using a cat to threaten the mice and by swimming until exhaustion daily which lasted about 21 days. Mice in the model group were administered 20 mL/ kg -1 · d -1 of normal saline intragastrically. The Jinkuishenqi Wan group was given 2.7 g/kg-1 · d-1 ofa solution of Jinkuishenqi Wan. The Zibushenjing Fang high dose group was given 20 g/kg -1 · d -1 and the Zibushenjing Fang low dose group was given 10 g/kg -1 · d -1 of a solution of Zibushenjing Fang.The general condition of all the groups was observed, including the quantity of food and water intake, swimming time, length of femur, and weight of the femur and musculus quadriceps femoris. The total superoxide dismutase (T-SOD), glutathione peroxi- dase (GSH-Px), and methane dicarboxylic aldehyde (MDA) activities in the brain tissues were detected. RESULTS: Zibushenjing Fang could improve the manifestation of kidney essence insufficiency, increase the quantity of food and water intake, swimming time, femur length, and femur and musculus quadriceps femoris weight. It could also regulate the activities of T-SOD, GSH-Px, and MDA in brain tissue. CONCLUSION: Zibushenjing Fang may play an important role in treating kidney essence insufficiency syndrome by promoting body development and improving brain tissue antioxidation. | Yuezhen He Junxiao Yao Shilin Shen Xiaojun Su Yuping Wang Li Li Wenhui Wang Jiping Shi | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 2 |
| 11 | Single view compositing with shadows显示文摘 | Xiaochun Cao Yuping Shen Mubarak Shah Hassan Foroosh | 2005 | The Visual Computer (-)2005，，8： | 1 |
| 12 | The protective effect of Zizyphus jujube fruit on carbon tetrachloride induced hepatic injury in mice by antioxidative activities 显示文摘 | Xiangehun Shen Yuping Tang Ruihui Yang | 2009 | Journal of Ethnopharmacology2009，122，3： | 1 |
| 13 | Extracellular high mobility group box chromosomal protein 1 promotesdrug resistance by increasing the expression of P?glycoprotein expression in gastricadenocarcinoma cells显示文摘 | Yuping Yin Wei Li Meizhou Deng Peng Zhang Qian Shen Guobing Wang Kaixiong Tao | 2014 | Molecular Medicine Reports2014，，4： | 1 |
| 14 | A photo-assisted electrochemical-based demonstrator for green ammonia synthesis显示文摘Bridging laboratory research and practical utilization is of crucial importance for the development of green ammonia synthetic technologies. A decentralized photo-assisted electrochemical-based demonstrator has been proposed for green ammonia synthesis from renewable electricity, air and water, where well-known defect-laden WO_(3) is used as the working electrode, and a commercially available PV panel supplies renewable electricity. In this demonstrator, defect-laden WO_(3) exhibits the optimum electrochemical NH_(3) formation rate(4.51 × 10^(-12)mol s^(-1)cm^(-2)) in 0.1 M K_(2)SO_(4)in a photovoltaic electrochemical(PV-EC) system. A system-level energy and cost analysis was conducted to investigate its economic viability and a general evaluation tool for system performance and cost estimation was proposed. This advance enables the possibility of integrating the small-scale green ammonia demonstrator into a stand-alone farm system. | Xiaolu Liu Zhurui Shen Xinyue Peng Lu Tian Ran Hao Lu Wang Yangfan Xu Yuping Liu Christos T.Maravelias Wei Li Geoffrey A.Ozin | 2022 | Journal of Energy Chemistry2022，31，5： | 1 |
| 15 | Synthesis and characterization of water-soluble conducting polyaniline by enzyme catalysis显示文摘 | Yuping Shen Jianzhong Sun | 2005 | Journal of Applied Polymer Science2005，96，3： | 1 |
| 16 | Fabrication and application of nano-microcrystalline composite diamond films on the interior hole surfaces of Co cemented tungsten carbide substrates显示文摘 | Sun Fanghong Ma Yuping Shen Bin | 2009 | Diamond and Related Materials''2009，18，2： | 1 |
| 17 | Gasoline Sensor Based on Flower-Like ZnO显示文摘<正>Flower-like ZnO was prepared through a hydrothermal process using zinc sulfate as raw material.The microstructure and morphology of the samples were characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM).XRD results showed that the as-obtained sample could be indexed to hexagonal wurtzite ZnO.TEM results revealed that the ZnO sample presented flower-like shape.The gas sensors were prepared with the traditional sintering process and their gas sensitivities were detected.The gas sensitivity results showed that the sensors based on flower-like ZnO were very sensitive to dilute 90~# gasoline.The relatively high sensitivity and selectivity of these sensors made from flower-like ZnO demonstrated the potential for developing a new class of selective gasoline sensors. | Xu Jiaqiang Chen Yuping Li Chao Shen Jianian | 2006 | 稀有金属材料与工程2006，35，A03： | 1 |
| 18 | Gas sensing properties of ZnO nanorods prepared by hydrothermal method显示文摘 | Xu Jiaqiang Chen Yuping Li Yadong Shen Jianian | 2005 | Journal of Materials Science2005，，11： | 1 |
| 19 | Synthesis of supermicro-macroporous silica with polypeptide-based triblock copolymer显示文摘 | Liu Yuping Li Liying Shen Zhurui | 2007 | Studies Surface Science and Catalysis2007，165，： | 1 |
| 20 | Feature of thermohaline circulation in two-layer conceptual model based on energy constraint显示文摘The assertion that the thermohaline circulation(THC)is driven and sustained by mechanical energy has been increasingly accepted.The simplest conceptual model describing the THC is the Stommel two-box model.Given the vertical stratification in the real ocean,layered models were designed and used.In this research,using a two-layer conceptual model based on energy constraint,we studied basic features of thermal-mode and saline-mode circulations.We focused on the effects of freshwater flux and mixing energy on the intensity and multiple equilibrium states of the THC.The results show that more important than affecting the THC intensity,both the decrease of freshwater flux and increase of mixing energy can lead to an'abrupt transition'in the THC from a stable saline to a stable thermal mode,which further develops the THC energy theory. | SHEN Yang GUAN YuPing | 2015 | Science China Earth Sciences2015，58，8： | 1 |
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