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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Fluoroscopy guided percutaneous renal access in prone position显示文摘Percutaneous nephrolithotomy is a very commonly done procedure for management of renal calculus disease. Establishing a good access is the first and probably themost crucial step of this procedure. A proper access is the gateway to success. However, this crucial step has the steepest learning curve for, in a fluoroscopy guided access, it involves visualizing a three dimensional anatomy on a two dimensional fluoroscopy screen. This review describes the anatomical basis of the renal access. It provides a literature review of all aspects of percutaneous renal access along with the advances that have taken place in this field over the years. The article describes a technique to determine the site of skin puncture, the angle and depth of puncture using a simple mathematical principle. It also reviews the common problems faced during the process of puncture and dilatation and describes the ways to overcome them. The aim of this article is to provide the reader a step by step guide for percutaneous renal access. | Gyanendra R Sharma Pankaj N Maheshwari Anshu G Sharma Reeta P Maheshwari Ritwik S Heda Sakshi P Maheshwari | 2015 | World Journal of Clinical Cases2015，3，3： | 5 |
| 3 | Electric polarization reversal and memory in a multiferroic material induced by magnetic fields显示文摘 | Hur N Park S Sharma P A | 2004 | Nature2004，429，： | 1 |
| 4 | Endometrial hormone receptors in women with dysfunctional uterine bleeding显示文摘 | CHAKRABORTY S KHURANA N SHARMA J B | 2005 | Arch Gynecol Obstet2005，272，1： | 1 |
| 5 | Structure of isocitrate lyase, a persistence factor of Mycobacterium tubercu losis显示文摘 | Sharma V Sharma S Hoener zu Bentrup N | 2000 | Nat Struct Biol2000，7，8： | 1 |
| 6 | Human Toll-like receptor 4 polymorphisms TLR4 Asp299Gly and Thr399Ile influence suscepti- bility and severity of puhnonary tuberculosis in the Asian Indian population 显示文摘 | Najmi N Kaur G Sharma S K | 2010 | Tissue Antigens2010，76，2： | 1 |
| 7 | Surgical con- siderations in pediatric necrotizing fasciitis 显示文摘 | Pandey A Gangopadhyay A N Sharma S P | 2009 | Indian Assoc Pediatr Surg2009，14，1： | 1 |
| 8 | Synthesis of self- assembled monodisperse 3 nm FePd nanoparticles: phase transition, magnetic study, and surface effect 显示文摘 | Gajbhiye N S Sharma S Ningthoujam R S | 2008 | Journal of Applied Physics2008，104，12： | 1 |
| 9 | Recurrent nested stromal epithelial tumor of the liver with extrahepatic metastasis:Case report and review of literature显示文摘 | Brodsky S V Sandoval C Sharma N | 2008 | Pediat Develop Pathol2008，11，： | 1 |
| 10 | Influence of long term fertilization on potassium adsorption kinetics parameters显示文摘 | SHARMA K N HARJIT S BHANDARI A L | 1994 | Journal of Potassium Research1994，10，4： | 1 |
| 11 | Drug-eluting balloon: new tool in the box显示文摘 | Sharma S Kukreja N Christopoulos C | 2010 | Expert Rev Med Devices2010，7，3： | 1 |
| 12 | Role of anthocyanidin reductase,encoded by BANYULS in plant flavonoid biosynthesis显示文摘 | Xie D Y Sharma S B Paiva N L | 2003 | Science2003，299，5605： | 1 |
| 13 | Evaluation of Natural Essential Oils as Antifeedants against Spodoptera litura显示文摘 | SHARMA R N DESHPANDE S G JOSEPH M | 1990 | Indian Perfumer1990，34，3： | 1 |
| 14 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 15 | Dendritc cell - based vaccine research against cancer 显示文摘 | Mody N Dubey S Sharma R | 2015 | Exper Rev Clin Immunol2015，11，2： | 1 |
| 16 | 显示文摘 | DEEPA M VARSHNEY P AGNIHOTRY S A | 2001 | Thin Solid Films2001，，401： | 1 |
| 17 | Proteome-level changes in two Brassica napus lines exhi-biting differential responses to fungal pathogen Alternaria brassicae 显示文摘 | Sharma N Rahman M H Strelkov S | 2007 | Plant Science2007，172，： | 1 |
| 18 | Quantum confinement effects of CdTe nanocrystals sequestered in TiO2 matrix: effect of oxygen incorporation 显示文摘 | Sharma S N Kohli S Rastogi A C | 2005 | Physica E2005，25，： | 1 |
| 19 | Triggering the interferon antiviral response through an IKK-related pathway显示文摘 | Sharma S Ten Oever BR Grandvaux N | 2003 | Science2003，300，5622： | 1 |
| 20 | Cerebrospinal fluid analysis in fatal thallium poisoning: evidence for de- layed distribution into the central nervous system显示文摘 | Sharma A N Nelson L S Hoffman R S | 2004 | Am J Forensic Med Pathol2004，25，2： | 1 |
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