| 1 | Correlation analysis between characteristics under gastroscope and image information of tongue in patients with chronic gastritis显示文摘OBJECTIVE:To explore the correlation between diagnostic information of tongue and gastroscopy results of patients with chronic gastritis.METHODS:Frequent pattern growth(FP-Growth),SPSS Modeler was used to analyze the correlation rules between the image information of tongue parameters and the characteristics of the stomach and duodenum seen under gastroscopy.RESULTS:Ranking in order of confidence:cyanotic tongue,slippery fur,yellow fur and spotted tongue were sequently associated with both gastric antrum mucosal hyperemia or edema and gastric antrum mucosal erythema/macula.L,one value of tongue coating color,which counted among(30,60),tooth-marked tongue and b,one value of tongue coating color,which counted in the range of(5,20)were sequently associated with gastric antrum mucosal erythema/macula.A,one value of tongue body color,which counted in the range of(0,20),was related to both gastric antrum mucosal hyperemia or edema and gastric antrum mucosal erythema/macula.a,one value of tongue coating color,which counted in the range of(15,35),was associated with gastric antrum mucosal erythema/macula.There are a total of 9 strong correlation rules.CONCLUSIONS:Cyanotic tongue,slippery fur,yellow fur,the CIE Lab value of tongue coating,a,the value of tongue body color,spotted tongue,and tooth-marked tongue are all related to the gastric antrum mucosal hyperemia or edema and gastric antrum mucosal erythema/macula.The conditions of gastric mucosa could be predicted by the examination of the above related image information of tongue. | SHANG Zimeng DU Zhengguang GUAN Bei JI Xingyu CHEN Longchang WANG Yongji MA Yun | 2022 | Journal of Traditional Chinese Medicine2022，42，1： | 2 |
| 2 | Effect of Dangfei Liganning capsule(当飞利肝宁胶囊) on liver X receptor α/steroid regulatory element binding protein-1/fatty acid synthase signal pathway in rats with metabolic-associated fatty liver disease显示文摘OBJECTIVE: To study the mechanism of Dangfei Liganning capsule(当飞利肝宁胶囊) in the treatment of rats with metabolic associated fatty liver disease(MAFLD). METHODS: Totally 48 specific pathogen free SpragueDawley male rats were randomly divided into normal Group, model group, Dangfei Liganning high, moderate, and low-dose groups and Essentiale group which were fed with high fat diet for 8 weeks, and gavage and molding were carried out simultaneously. Dangfei Liganning high, middle and low-dose group were given 0.27, 0.135 and 0.0675 g·kg-1·d-1 respectively by gavage, Essentiale group was given 0.123 g·kg-1·d-1 by gavage, the same amount of distilled water was given by gavage in the normal group and the model group. The rats were weighed at the 0th week, 2nd week, 4th week, 6th week and 8th weekend respectively. The rats were sacrificed at the end of the 8th week. Serum levels of alanine aminotransferase(ALT), alanine aminotransferase(AST),triglyceride(TG), total cholesterol(CHO), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein (LDL-C), total protein(TP), albumin(Alb), globulin(GLB), total bilirubin(TBIL), direct bilirubin(DBIL), tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) were measured. The levels of liver tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) and liver pathology [hematoxylin and eosin(HE) staining, oil red O staining] were detected. The expression levels of liver X receptor α(LXRα), steroid regulatory element binding protein-1(SREBP-1) and fatty acid synthase(FAS) were detected by immunohistochemistry, Western blot and reverse transcription-polymerase chain reaction reverse transcription-polymerase chain reaction. RESULTS: From the beginning to the 8th week, the growth rate of body weight in the Dangfei Liganning highdose group was slower than all other groups. There was no significant difference in ALB level in all groups(P > 0.05). Compared with the model group, the levels of ALT, AST, LDL-C, TG, CHO, TP, GLB, TBIL, DBIL, IL-6, TNF-α were significantly decreased and HDL-C were significantly increased in Dangfei Liganning high-dose group(P < 0.01, < 0.05). HE and oil red O staining showed that the fatty lesions in rat liver were alleviated, while the expressions of LXRα, SREBP-1, FAS m RNA and protein were significantly decreased(P < 0.01). CONCLUSIONS: Dangfei Liganning capsule can slow down the increase of body weight of MAFLD rats, reduce the levels of transaminase, Lipid and inflammatory factors in MAFLD rats, promote the synthesis of liver protein and bile metabolism, and improve the liver fatty lesion of MAFLD rats, among which the Dangfei Liganning highdose group is more effective. The mechanism of action may be through blocking LXR-SREBP-1-FAS signal pathway. | LI Xiaoling SUN Fengxia SHANG Zimeng ZHANG Yingxue LI Jie ZHANG Qiuxiang | 2022 | Journal of Traditional Chinese Medicine2022，42，6： | 2 |
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