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| 1 | Non-genetic contributions of the sperm nucleus to embryonic development显示文摘从几个实验室的最近的数据提供了最新使肥沃的卵母细胞从为合适的胚胎的开发被要求的精子染色质继承 epigenetic 信号的证据。为这评论的目的,术语 epigenetic 被用来描述从精子房间被传给胚胎的分子的信息的所有类型。当在哺乳动物或为为哪个有证据,它可以那么做为合适的 embryogenesis 被要求,有已经被建立了的 epigenetic 信息的至少六种不同形式。这些是(i) DNA methylation;(ii ) 精子特定的 histones,(iii ) 另外的联系染色质的蛋白质;(iv ) perinuclear 膜蛋白质;(v) 精子出生的 RNA 并且,这评论的焦点;并且(vi ) 由精子的 DNA 环领域组织原子矩阵。当为有效授精和随后的胚胎开发作为必要部件为帮助繁殖技术为精子的操作和 cryopreservation 设计协议时,这些 epigenetic 信号应该被考虑。 | Yasuhiro Yamauchi Jeffrey A Shaman W Steven Ward | 2011 | Asian Journal of Andrology2011，13，1： | 6 |
| 2 | Influence of non‐alcoholic fatty liver disease on the development of diabetes mellitus显示文摘 | Anuradhani Kasturiratne Sanjaya Weerasinghe Anuradha S Dassanayake Shaman Rajindrajith Arjuna P Silva Norihiro Kato A Rajitha Wickremasinghe H Janaka Silva | 2012 | J Gastroenterol Hepatol2012，，1： | 2 |
| 3 | The Structure and Governance of Venture-Capital Organizations显示文摘 | Shaman W A | 1999 | Journal of Financial Economics1999，，27： | 1 |
| 4 | Topoisomerase Ⅱ -mediated breaks in spermatozoa cause the specific degradation of paternal DNA in fertilized oocytes显示文摘 | YAMAUCHI Y SHAMAN J A WARD W S | 2007 | Biol Reprod2007，76，4： | 1 |
| 5 | Photochem- ical Effects of Laser Irradiation on Neuritic Outgrowth of Olfac- tory Neuroepithelial Explants 显示文摘 | MESTER A F JR SNOW J B SHAMAN P | 1991 | Otolaryngol Head Neck Stag1991，105，3： | 1 |
| 6 | Generic and disease-specific health-related quality of life in patients with Hirschsprung disease:A systematic review and meta-analysis显示文摘BACKGROUND Patients with Hirschsprung disease(HD)are at risk of persistent constipation,fecal incontinence or recurrent enterocolitis after surgical treatment,which in turn may impact physical and psychosocial functioning.Generic health-related quality of life(HRQoL)and disease-specific health-related quality of life are relevant outcome measures to assess the impact of HD on the QoL of these patients.AIM To summarize all available evidence on HRQoL of patients with HD after surgery and the impact of possible moderating factors.METHODS Pubmed,Web of Sciences,Psyc Info and Embase were searched with search terms related to’Hirschsprung disease’,’Pediatrics’and’Quality of life’.Mean and standard deviation of generic HRQoL overall and domain scores were extracted from each study,as well as data describing potential factors associated with QoL.Random effect models were used for meta-analytic aggregation of generic HRQoL scores.Meta-regression was used to assess the relationship between patient and clinical characteristics and generic HRQoL.Disease-specific HRQoL outcomes of patients with HD were systematically reviewed.RESULTS Seventeen articles were included in the systematic review(n=1137 patients)and 15 in the quantitative meta-analysis(n=1024 patients).Four studies reported disease-specific HRQoL.Patient’s age ranged between 0 and 21 years.Meta-analytic aggregation showed a nonsignificantly impaired generic HRQoL(d=-0.168[95%CI:-0.481;0.145],P=0.293,I^(2)=94.9)in patients with HD compared to healthy controls.Physical(d=-0.042[95%CI:-0.419;0.335],P=0.829,I^(2)=95.1),psychosocial(d=-0.159[95%CI:-0.458;0.141],P=0.299,I^(2)=93.6)and social HRQoL(d=-0.092[95%CI:-0.642;0.457],P=0.742,I^(2)=92.3)were also not significantly lower compared to healthy controls.There was no relation between health-related outcomes and the sex of the patients and whether generic HRQoL was measured by parental proxy or self-report.Disease-specific complaints of patients with HD impaired physical HRQoL,but not psychosocial and social HRQoL.CONCLUSION In this systematic review and meta-analysis,no evidence was found for impaired generic HRQoL in patients with HD compared to healthy controls,neither for moderating effects of sex,parental proxy or self-report. | Veerle Huizer Naveen Wijekoon Daniëlle Roorda Jaap Oosterlaan Marc A Benninga LW Ernest van Heurn Shaman Rajindrajith Joep PM Derikx | 2022 | World Journal of Gastroenterology2022，28，13： | 1 |
| 7 | The effect of normalization norms in multiple attribute decision making models: A case study in gear material selection 显示文摘 | MILANI A S SHAMAN A MADOLIAT R | 2005 | Structural and Multidisciplinary Optimization2005，4，： | 1 |
| 8 | Constipation-associated and Nonretentive Fecal Incontinence in Children and Adolescents: An Epidemiological Survey in Sri Lanka显示文摘 | Shaman Rajindrajith Niranga Manjuri Devanarayana Marc A Benninga | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，4： | 1 |
| 9 | The bias of autoregressive coefficients es- timators显示文摘 | Shaman P Stine R A | 1988 | Journal of American Statistical Association1988，83，403： | 1 |
| 10 | A fixed point characterization for bias of autoregressive estimators 显示文摘 | Shaman P Stine R A | 1989 | Annals of Statistics1989，17，3： | 1 |
| 11 | Forecasting seasonal outbreaks ofinfluenza 显示文摘 | Shaman J Karspeck A | 2012 | PNAS2012，109，20： | 1 |
| 12 | A Material Selection Model Based on the Concept of Multiple Attribute Decision Making显示文摘 | ShaMan A Savadogo O | 2006 | Materials and Design2006，27，4： | 1 |
| 13 | Topoisomerase ⅡB and an extracellular nuclease interact to digest sperm DNA in an apoptotic-like manner显示文摘 | Shaman J A Prisztoka R Ward W S | 2006 | Biol Reprod2006，75，5： | 1 |
| 14 | Blockage of heregulin expression inhibits tumorigenicity and metastaaia of breast cancer 显示文摘 | Tsai M S Shaman - Taylor L A Mehmi I el al | 2003 | Oncogene2003，22，5： | 1 |
| 15 | Childhood constipation:Current status,challenges,and future perspectives显示文摘Constipation in children is a major health issue around the world,with a global prevalence of 9.5%.They present to clinicians with a myriad of clinical signs.The Rome IV symptom-based criteria are used to diagnose functional constipation.Functional constipation is also a huge financial burden for healthcare system and has a detrimental impact on health-related quality of life of children.There are various risk factors identified globally,including centrally connected factors such as child abuse,emotional and behavioral issues,and psychological stress.Constipation is also precipitated by a low-fiber diet,physical inactivity,and an altered intestinal microbiome.The main pathophysiological mechanism is stool withholding,while altered rectal function,anal sphincter,pelvic floor,and colonic dysfunction also play important roles.Clinical evaluation is critical in making a diagnosis,and most investigations are only required in refractory patients.In the treatment of childhood constipation,both nonpharmacological(education and demystification,dietary changes,toilet training,behavioral interventions,biofeedback,and pelvic floor physiotherapy),and pharmacological(osmotic and stimulant laxatives and novel drugs like prucalopride and lubiprostone)interventions are used.For children with refractory constipation,transanal irrigation,botulinum toxin,neuromodulation,and surgical treatments are reserved.While frequent use of probiotics is still in the experimental stage,healthy dietary habits,living a healthy lifestyle and limiting exposure to stressful events,are all beneficial preventive measures. | Shaman Rajindrajith Niranga Manjuri Devanarayana Marc A Benninga | 2022 | World Journal of Clinical Pediatrics2022，11，5： | 0 |
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