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| 1 | Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk显示文摘AIM: To examine the relationships between pre-diagnostic biomarkers and colorectal cancer risk and assess their relevance in predictive models.METHODS: A nested case-control study was designed to include all first primary incident colorectal cancer cases diagnosed between inclusion in the SUpplémentation en VItamines et Minéraux AntioXydants cohort in 1994 and the end of follow-up in 2007. Cases (n = 50) were matched with two randomly selected controls (n = 100). Conditional logistic regression models were used to investigate the associations between pre-diagnostic levels of hs-CRP, adiponectin, leptin, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1, E-selectin, monocyte chemoattractant protein-1 and colorectal cancer risk. Area under the receiver operating curves (AUC) and relative integrated discrimination improvement (RIDI) statistics were used to assess the discriminatory potential of the models. RESULTS: Plasma adiponectin level was associated with decreased colorectal cancer risk (P for linear trend = 0.03). Quartiles of sVCAM-1 were associated with increased colorectal cancer risk (P for linear trend = 0.02). No association was observed with any of the other biomarkers. Compared to standard models with known risk factors, those including both adiponectin and sVCAM-1 had substantially improved performance for colorectal cancer risk prediction (P for AUC improvement = 0.01, RIDI = 26.5%). CONCLUSION: These results suggest that pre-diagnostic plasma adiponectin and sVCAM-1 levels are associated with decreased and increased colorectal cancer risk, respectively. These relationships must be confirmed in large validation studies. | Mathilde Touvier Léopold Fezeu Namanjeet Ahluwalia Chantal Julia Nathalie Charnaux Angela Sutton Caroline Méjean Paule Latino-Martel Serge Hercberg Pilar Galan Sébastien Czernichow | 2012 | World Journal of Gastroenterology2012，18，22： | 15 |
| 2 | Corticosteroid therapy for patients in septic shock:Some progress in a difficult decision显示文摘 | Charles L Sprung Mayer Brezis Serge Goodman | | 0，，03： | 1 |
| 3 | Ultrasonic degradation at 20 k Hz and 500 k Hz of atrazine and pentachlorophenol in aqueous solution:Preliminary results显示文摘 | Christian P Bernard D Serge L | 1996 | Chemosphere1996，32，9： | 1 |
| 4 | A new cold-induced alfalfa gene is associated with enhanced hardening at subzero temperature显示文摘 | MONROY A F YVES C SERGE L | 1993 | Plant Physid1993，102，： | 1 |
| 5 | Cold-adapted rhizobia for nitrogen fixation in temperate regions1显示文摘 | DANIELLE P PASCAL D SERGE L | 2003 | Canadian Journal of Botany2003，81，12： | 1 |
| 6 | Recent advances in the use of zinc borates in flame retardancy of EVA显示文摘 | SERGE B MICHEL L B ROBERT L | 1999 | Polymer Degradation and Stability1999，64，3： | 1 |
| 7 | Charring of fire retarded ethylene vinyl acetate copolymer-magnesium hydroxide/zinc borate formulations显示文摘 | FABIEN C SERGE B MICHEL L B | 2000 | Polymer Degradation and Stability2000，69，1： | 1 |
| 8 | New formulation of vasoactive intestinal peptide using liposomes in hyaluronic acid gel for uveitis显示文摘 | Laure L Serge C Florence A | 2009 | J Contr Release2009，139，1： | 1 |
| 9 | Carbonization Mechanisms Resulting from Intumescence Association with the Ammonium Polyphosphate显示文摘 | SERGE B MICHEL L B RENE D | 1993 | Pentaerythritol Fire Retardant System Carbon1993，31，： | 1 |
| 10 | What does the fulture hold for BNP in cardiology? 显示文摘 | Robertol L Aldo PM Serge M | 2001 | Heart2001，86，： | 1 |
| 11 | PA-6 clay nanocomposite hybrid as char forming agent in intumescent for formulations显示文摘 | Serge B Michel L B Franyois D | 2000 | Fire and Materials2000，24，4： | 1 |
| 12 | Structural insight into the south Ryukyu margin:effects of the subducting Gagua Ridge显示文摘 | Schnüde P Liu Char-Shine Serge E Reed D L | | 0，，： | 1 |
| 13 | Effect of low central venous pressure and phlebotomy on blood product transfusion requirements during liver transplantation 显示文摘 | LUC M SERGE L | 2006 | Liver Transplantation2006，12，1： | 1 |
| 14 | The Origin and Nature of Flame Retardance in Ethylene-vinyl Acetate Copolymers containing Hostaflam AP 750显示文摘 | Michel B Serge B Michel L B | 1999 | Polymer International1999，48，： | 1 |
| 15 | Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1显示文摘 | Cagatay G Serge L Alain P | 2000 | Cancer Res2000，60，： | 1 |
| 16 | Effects of Valsartanon circulating brain natriuretic peptide an norepingphrineinsy NptoNatic chronic heart failure显示文摘 | Robeo L Serge N Inder A | 2002 | Circulation2002，106，19： | 1 |
| 17 | State of the art of vehicular traffic flow modeling 显示文摘 | SERGE P H PIET H L B | 2001 | Proceedings of the Institution of Mechanical Engineers: Part I: Journal of Systems and Control Engineering2001，215，4： | 1 |
| 18 | Recent advances for intumescent polymers显示文摘 | Serge B Michel L B Sophie D | 2004 | Macromol Mater Eng2004，289，： | 1 |
| 19 | Toll-like receptor TLR-2 and TLR-4 regulate infammation, gliosis and myelin sparing after spinal cord injury显示文摘 | Kristina A K Wenmin L Serge R | 2007 | J Neurochem2007，102，1： | 1 |
| 20 | The translational factor elF3f; the ambivalent eIF3 subunit显示文摘 | Roberta M Serge AL Jean-Luc L | 2013 | Cell Mol Life Sei2013，70，19： | 1 |
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