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| 1 | Long-term outcomes and prognostic factors of patients with obstructive colorectal cancer: A multicenter retrospective cohort study显示文摘AIM: To investigate the long-term oncologic outcomes and prognostic factors in patients with obstructive colorectal cancer(CRC) at multiple Japanese institutions.METHODS: We identified 362 patients diagnosed with obstructive colorectal cancer from January 1, 2002 to December 31, 2012 in Yokohama Clinical Oncology Group's department of gastroenterological surgery. Among them, 234 patients with stage Ⅱ/Ⅲ disease who had undergone surgical resection of their primary lesions were analyzed, retrospectively. We report the long-term outcomes, the risk factors for recurrence, and the prognostic factors.RESULTS: The five-year disease free survival and cancer-specific survival were 50.6% and 80.3%, respectively. A multivariate analysis showed the ASAPS(HR = 2.23, P = 0.026), serum Albumin ≤ 4.0 g/d L(HR = 2.96, P = 0.007), T4 tumor(HR = 2.73, P = 0.002) and R1 resection(HR = 6.56, P = 0.02) to be independent risk factors for recurrence. Furthermore, poorly differentiated cancers(HR = 6.28, P = 0.009), a T4 tumor(HR = 3.46, P = 0.011) and R1 resection(HR = 6.16, P = 0.006) were independent prognostic factors in patients with obstructive CRC.CONCLUSION: The outcomes of patients with obstructive CRC was poor. T4 tumor and R1 resection were found to be independent prognostic factors for both recurrence and survival in patients with obstructive CRC. | Ishibe Atsushi Ota Mitsuyoshi Yamaguchi Kazuya Kaida Syuhei Kamiya Noriyuki Momiyama Masashi Watanabe Akira Sekizawa Kentaro Kamimukai Nobuyuki Sugimasa Natsuko Watanabe Jun Ichikawa Yasushi Kunisaki Chikara Endo Itaru | 2016 | World Journal of Gastroenterology2016，22，22： | 9 |
| 2 | Malignant transformation of endometriosis and genetic alterations of K- ras and microsatellite instability显示文摘 | Amemiya S Sekizawa A Otsuka J | 2004 | Int J Gynaecol Obstet2004，86，3： | 1 |
| 3 | Malignant transfor-mation of endometriosis:application of laser microdissection for analysis ofgenetic alterations according to pathological changes显示文摘 | Sekizawa A Amemiya S Otsuka J | 2004 | Med ElectronMicrosc2004，37，2： | 1 |
| 4 | Silent cerebral infarction: a potentiential risk for pneumonia in the elderly显示文摘 | Nakagawa T Sekizawa K Nakajoh K | 2000 | J Intern Med2000，247，2： | 1 |
| 5 | Prenatal diagnosis of duchenne muscular dystrophy using a single fetal nucleated erythrocyte in maternal blood显示文摘 | SEKIZAWA A KIMURA T SASAKI M | 1996 | Neurology1996，46，5： | 1 |
| 6 | Effects of inhaled beclomethasone dipropionate on serum IgE levels and clinical symptoms in atopic asthma显示文摘 | Ohrui T Funayama T Sekizawa K | 1999 | Clin Exp Allergy1999，29，3： | 1 |
| 7 | Relation between incidence of pneumonia and protective reflexes in post- stroke patients with oral or tube feeding显示文摘 | Nakajoh K Nakagawa T Sekizawa | 2000 | J Intern Med2000，247，1： | 1 |
| 8 | Prenatal DNA diagnosis of a single gene disorders from maternal plasma 显示文摘 | Sekizawa A Morimoto T | 2000 | Lancet2000，356，9236： | 1 |
| 9 | Increased carbon monoxide in exhaled air of asthmatic patients显示文摘 | Zayazu K Sekizawa K Okinaga S | 1997 | Am J Respir Crit Care Med1997，156，： | 1 |
| 10 | Apoptosis in fetal nucleated erythrocytes circulating in maternal blood显示文摘 | Sekizawa A Samura O Zhen DK | 2000 | Prenat Diagn2000，20，11： | 1 |
| 11 | Relation between incidence of pneumonia and protective reflexes in post-stroke patients with oral or tube feeding 显示文摘 | Nakajoh K Nakagawa T Sekizawa K | 2000 | J Intern Med2000，247，1： | 1 |
| 12 | Performance of messenger RNAs circulating in maternal blood in the prediction of preecIampsia at 10-14 weeks 显示文摘 | Farina A Zucchini C Sekizawa A | 2010 | Am J Obstet Gynecol2010，203，6： | 1 |
| 13 | Interstitial pneumonia developed in a worker dealing with particles containing indium-tin oxide显示文摘 | HOMMA T UENO T SEKIZAWA K | | 0，，03： | 1 |
| 14 | MMP14 gene polymorphisms in chronic obstructive pulmonary disease显示文摘 | Saitoh W Sakamoto T Hegab A E Nomura A Ishii Y Morishima Y Kai S Iizuka T Kiwamoto T Matsuno Y Massoud H H Massoud H M Hassanein K M Sekizawa K | 2006 | Int J Mol Med2006，17，6： | 1 |
| 15 | Prenatal diagnosis of Dunchenne muscular dystrophy using a single fetal nucleated erythrocyte in maternal blood显示文摘 | Sekizawa A Kimura T Sasaki M | 1996 | Neurology1996，46，5： | 1 |
| 16 | Relation between in cidence of pneumonia and protective reflexes in post - stroke pa tients with oral or tube feeding显示文摘 | Nakajoh K Nakagawa T Sekizawa K | 2000 | J Intern Meal2000，247，1： | 1 |
| 17 | Cabergoline and silent as- piration in elderly patients with stroke 显示文摘 | Arai T Sekizawa K Yashimi N | 2003 | J Am Genatr Soc2003，51，12： | 1 |
| 18 | Apoptosis in fetal nucleated erythrocytes circulating in maternal blood显示文摘 | Sekizawa A Samura 0 Zhen D K | 2000 | Prenat Diagn2000，20，11： | 1 |
| 19 | Low-dose effects of bisphenol A: a serious threat to human health?显示文摘 | Sekizawa J | 2008 | J Toxieol Sei2008，33，4： | 1 |
| 20 | Increased cell -free fetal DNA in plasma of two women with invasive placenta显示文摘 | SEKIZAWA A JIMBO M SAITO H | 2002 | Clin Chem2002，48，： | 1 |
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