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| 1 | Evaluation of quantitative contrast harmonic imaging to assess malignancy of liver tumors:A prospective controlled two-center study显示文摘AIM: To establish the extent to which contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics facilitates the detection of hepatic tumors. METHODS: One hundred patients with histologically confirmed malignant or benign hepatic tumor (maximum size 5 cm) were analyzed. Contrast-enhanced ultrasound (bolus injection 2.5 mL SonoVue) was carried out with intermittent breath-holding technique using a multifrequency transducer (2.5-4 MHz). Native vascularization was analyzed with power Doppler. The contrast-enhanced dynamic ultrasound investigation was carried out with contrast harmonic imaging in true detection mode during the arterial,portal venous and late phases. Mechanical index was set at 0.15. Perfusion analysis was performed by post-processing of the raw data time intensity curve (TIC) analysis. The cut-off of the gray value differences between tumor and normal liver tissue was established using Receiver Operating Characteristic (ROC) analysis 64-line multi-slice computed tomography served as reference method in all cases. Magnetic resonance tomography was used additionally in 19 cases. RESULTS: One hundred patients with 59 malignant (43 colon,5 breast,2 endocrine metastases,7 hepatocellular carcinomas and 2 kidney cancers) and 41 benign (15 hemangiomas,7 focal nodular hyperplasias,5 complicated cysts,2 abscesses and 12 circumscribed fatty changes) tumors were included. The late venous phase proved to be the most sensitive for classification of the tumor type. Fifty-eight of the 59 malignant tumors were classified as true positive,and one as false negative. This resulted in a sensitivity of 98.3%. Of the 41 benign tumors,37 were classified as true negative and 4 as false negative,which corresponds to a specificity of 90.2%. Altogether,95.0% of the diagnoses were classified as correct on the basis of the histological classification. No investigator-dependency (P = 0.23) was noted. CONCLUSION: The results show the possibility of accurate prediction of malignancy of hepatic tumors with a positive prognostic value of 93.5% using advanced contrast-enhanced ultrasound. Contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics is a valuable tool to discriminate hepatic tumors. | EM Jung DA Clevert AG Schreyer S Schmitt J Rennert R Kubale S Feuerbach F Jung | 2007 | World Journal of Gastroenterology2007，13，47： | 15 |
| 2 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 3 | 轿车和载货车用发动机的两级可调增压系统显示文摘当前的技术现状是,带有可变涡轮几何截面的涡轮增压器装在轿车和部分载货车用柴油机上后,一级增压技术的极限就显而易见了。提高标定功率大多会使起动扭矩恶化,为了解决这个难题,介绍一种由Borg-Warner公司研发的两级可调增压系统(R2S)。 | Chiristmann R | 2006 | 国外内燃机2006，38，1： | 3 |
| 4 | Influence of the layer charge and clay particle size on the interactions between the cationic dye methylene blue and clays in an aqueous suspension显示文摘 | NEUMANN M G GESSNER F SCHMITT C C | 2002 | J Colloid Interface Sci2002，255，： | 2 |
| 5 | Identification of molecular phenotypes in canine mammary carcinomas with clinical irnplications: application of the human classification 显示文摘 | Gama A Alves A Schmitt F | 2008 | Virchows Arch2008，453，： | 1 |
| 6 | Renal effects of angiotensin Ⅱ-receptor blocka-ed and angiotensin convertase inhibition in man 显示文摘 | Schmitt F Natov S Martinez F | 1996 | Clin Sci1996，90，3： | 1 |
| 7 | Multifractal analysis of the dollar-yuan and euro-yuan exchange rate before and after the reform of the peg显示文摘 | Schmitt F G Ma Li Angounou T | 2011 | Quantitative Finance2011，11，4： | 1 |
| 8 | Effect of a dominant-negative form of ADAM10 in a mouse model of Alzheimer's disease显示文摘 | Schroeder A Fahrenholz F Schmitt U | 2009 | Alzheimers Dis2009，16，2： | 1 |
| 9 | Urokinase-type plasminogen activator (uPA) and its receptor (CD87):A new target in tumor invasion and metastasis显示文摘 | Schmitt M Wilhelm O Janicke F | 1995 | Obstet Gynaecol1995，21，2： | 1 |
| 10 | The viral killer system in yeast:from molecular biology to application显示文摘 | SCHMITT M J BREINIG F | 2002 | FEMS Microbiol Rav2002，，26： | 1 |
| 11 | Lactoferrin and cancer disease prevention显示文摘 | RODRIGUES L TEIXEIRA J SCHMITT F | 2009 | Crit Rev Food Sci Nutr2009，49，3： | 1 |
| 12 | The effects of plant extracts of Reynoutria sachalinensis on powdery mildew development and leaf physiology of long English cucumber显示文摘 | Daayf F Schmitt A Belanger R | 1995 | Plant Disease1995，79，： | 1 |
| 13 | Surface reconstruction from unstructured 3D data显示文摘 | Algorri M E Schmitt F | 1996 | Computer Graphics Forum1996，15，1： | 1 |
| 14 | Islet 1 (Isll) expression is a reliable marker for pancreatic endocrine :urnors and their metastases 显示文摘 | Schmitt A M Riniker F Anlauf M st al | 2008 | Am J Surg Pathol2008，32，3： | 1 |
| 15 | Genetic and diet effects on Ppar-α and Ppar-γ signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesity显示文摘 | Waqener A Goessling H F Schmitt A O | | 0，，99： | 1 |
| 16 | Multistatic and multiple frequency imaging resolution analysis-application to GPS-based multistatic radar显示文摘 | Daout F Schmitt F Ginolhac G | | 0，，4： | 1 |
| 17 | EGFR/HER2 in breast cancer:a biological approach for molecular diagnosis and therapy显示文摘 | Milanezi F Carvalho S Schmitt FC | | 0，，： | 1 |
| 18 | Mechanisms of hypothermia- induced cell protection in the brain显示文摘 | Schmitt KR Tong G Berger F | 2014 | Mol Cell Pediatr2014，1，1： | 1 |
| 19 | PIV5 M protein interaction with host protein angiomotin-like 1 显示文摘 | Pei Z F Bai Y T Schmitt A P | 2010 | Virology2010，39，1： | 1 |
| 20 | Mesh Simplification显示文摘 | Algorri ME Schmitt F | 1996 | Computer Graphics Forum1996，15，3： | 1 |
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