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52篇 您的检索式：作者名="SCHLEIF"

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	题名	作者	年代	出处	被引量
1	星形胶质细胞转录组分析指导的脑卒中靶标鉴定显示文摘星形胶质细胞支持正常的脑功能,但在卒中等病理条件下,星形胶质细胞反应性激活,其也可能参与神经退行性改变。反应性星形胶质细胞增生对机体有益或有害,与环境背景有关,但其分子基础仍未得到充分解释。借助RiboTag技术,我们在特异性地短暂性大脑中动脉闭塞(tMCAO)72h后的小鼠星形胶质细胞中,纯化翻译mRNA,构建卒中特异性星形胶质细胞翻译组数据库。我们发现,与对照组脑组织相比,tMCAO后的反应性星形胶质细胞显示与A2表型相关的转录物的富集,这与神经保护相关。星形胶质细胞也会上调大量潜在的神经毒性基因。我们共鉴定了1003个基因和38个转录因子的差异表达,其中Stat3,Sp1和Spi1变化最明显。为了进一步探索Stat3介导的通路对卒中发病机制的影响,我们选择星形胶质细胞特异性条件性缺失Stat3的小鼠制造tMCAO模型,发现这些小鼠的局灶性缺血卒中体积减少,且梗死72h后小鼠的运动结果改善。综上所述,本研究扩展了新兴的星形胶质细胞特异性靶向卒中治疗数据库,并肯定了星形胶质细胞是脑功能的关键保障细胞。	Rakers C Schleif M Blank N Matu?ková H Ulas T H?ndler K Torres SV Schumacher T Tai K Schultze JL Jackson WS Petzold GC 聂昊	2019	神经损伤与功能重建2019，14，6：	2
2	Anxiety,depression,and quality of life in German ambulatory breast cancer patients显示文摘	Schleife H Sachtleben C Barboza C F	2014	Breast Cancer2014，21，8：	1
3	L-arabinose transport systems in Escherichia coil K-I 2 显示文摘	Kolodrubetz D Schleif R	1981	Journal of Bacteriology1981，148，2：	1
4	Developments in computational intelligence and machine learning显示文摘	BIEHL M GHIO A SCHLEIF F M	2015	Neurocomputing2015，，169：	1
5	Prevention of HIV-1 in-fection in chimpanzees by gp120 V3 domain-specific monoclonal anti-body显示文摘	Emini E A Schleif W A Nunberg J H	1992	Nature1992，355，6362：	1
6	Differentiation between probiotic and wild-type Bacillus cereus isolates by antibiotic susceptibility test and Fourier transform infrared spectroscopy (FT-IR) 显示文摘	Mietke H Beer W Schleif 3	2010	International Journal of Food Microbiology2010，140，1：	1
7	Antigenic conserva- tion and divergence between the viral-specific proteins of poliovir- us type 1 and various picornaviruses显示文摘	Emini EA Schleif WA Colonno RJ	1985	Virology1985，140，1：	1
8	DNA loop 显示文摘	Schleif R	1992	Annual Review of Biochemistry1992，6，1：	1
9	Regulation of the L-arabinose operonof Escherichia coli显示文摘	SCHLEIF ROBERT	2000	Trends in Genetics2000，16，12：	1
10	Optical and erengy-loss spectra of MgO,ZnO,and CdO from ad initio many-boby calculations显示文摘	Schleife A Rdl C Fuchs F	2009	Phys Rev B2009，80，03：	1
11	Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain beta-amyloid production 显示文摘	Arendash GW Schleif W Rezai-Zadeh K	2006	Neuroscience2006，142，4：	1
12	Damping for the Northwest- Southwest tie line oseillationsz an analog study显示文摘	SCHLEIF F R WHITE J H	1966	IEEE Trans on Power Apparatus and Systems1966，85，12：	1
13	Advances in artificial neural net- works,machine learning,and computational intelligence显示文摘	LEE J A SCHLEIF F M THOMAS M	2011	Kybernetes2011，74，9：	1
14	Prevention of HIV-1 infection in chimpanzees by gp120 V3 domain-specific monoclonal antibody显示文摘	Emini EA Schleif WA Nunberg JH	1992	Nature1992，355，6362：	1
15	In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors显示文摘	Schleif WA Blahy OM Gabryelski LJ Graham DJ Quintero JC Rhodes A Robbins HL Roth E Shiv-aprakash M Titus D Yang T Teppler H Squires KE Deutsch PJ Emini EA	1995	Nature1995，374，：	1
16	Caffeine protects Alzheimer' s mice against cognitive impairment and reduces brainl3- amyloidproduction 显示文摘	Arendash GW Schleif W Rezai-Zadeh K	2006	Neuroscience2006，142，：	1
17	Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain beta-amyloid production显示文摘	Arendash GW Schleif W Rezai-Zadeh K	2006	Neuroscience2006，142，：	1
18	Arac/XylS family of transcriptional regulators显示文摘	GALLEGOS M T SCHLEIF R BAIROCH A	1997	Microbiol Mol Biol1997，61，：	1
19	Damping for the Northwest- Southwest Tie Line Oscillations an Analog Study显示文摘	SCHLEIF F P WHITE J H	1966	IEEE Transactions on Power Apparatus and Systems1966，85，12：	1
20	Comparison of relevance learning vector quantization with other metric adaptive classification methods显示文摘	Villmann T Schleif F Hammer B	2006	Neural Networks2006，19，5：	1

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