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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | Potential role of metabolomics in diagnosis and surveillance of gastric cancer显示文摘Gastric cancer is one of the deadliest cancers worldwide, and is especially prevalent in Asian countries. With such high morbidity and mortality, early diagnosis is essential to achieving curative intent treatment and long term survival. Metabolomics is a new field of study that analyzes metabolites from biofluids and tissue samples. While metabolomics is still in its infancy, there are numerous potential applications in oncology, specifically early diagnosis. Only a few studies in the literature have examined metabolomics' role in gastric cancer. Various fatty acid, carbohydrate, nucleic acid, and amino acid metabolites have been identified that distinguish gastric cancer from normal tissue and benign gastric disease. However, findings from these few studies are at times conflicting. Most studies demonstrate some relationship of cancer cells to the Warburg Effect, in that glycolysis predominates with conversion of pyruvate to lactate. This is one of the most consistent findings across the literature. There is less consistency in metabolomic signature with respect to nucleic acids, lipids and amino acids. In spite of this, metabolomics holds some promise for cancer surveillance but further studies are necessary to achieve consistency and validation before it can be widely employed as a clinical tool. | Angela W Chan Richdeep S Gill Daniel Schiller Michael B Sawyer | 2014 | World Journal of Gastroenterology2014，20，36： | 9 |
| 3 | 美国高等医学考试体制及借鉴显示文摘一、美国医学教育体制及相匹配的考试体制以1992年资料为准,美国医学教育分为三阶段(个别情况除外)。 1.在校医学教育(Undergraduate MedicalEducation)。美国大学生获学士学位以后,申请报名参加全美医学院校入学考试(Medical College Admis-sion Test)。考试以后,由各医学院自行决定录取。进入医学院学习,为期四年,前两年为基础医学教育,后两年为临床医学教育。 1992年,报名36800人,录取17027新生,录取率为46%,其中88%已获学士学位,7.3%已获硕士或博士学位。女生占40%。 1992年全美共126所医学院,总计在校生为65539名,当年毕业生为15466人,当年淘汰率1.3%。与之相匹配的考试制度:在校学生要参加两方面考试,一方面是各学科课程考试及实习考试。 | 孙宝志 Norcini J Sawyer W | 1993 | 中国高等医学教育1993，，6： | 7 |
| 4 | Radiation-induced meningiomas: clinical, pathological, cytokinetic, and cytogenetic characteristics(英文)显示文摘OBJECTIVE: Radiation-induced meningiomas are known to occur after high and low-dose cranial radiation therapy. The goal of this study was to discern the distinguishing findings and characteristics of radiation-induced meningiomas. METHODS: The records of 16 patients (seven men and nine women) who fulfilled the criteria for radiation-induced meningiomas were retrospectively reviewed.Clinical, histopathological, cytokinetic,and cytogenetic findings as well as the patients' outcome were analyzed. The mean age of the patients was 38.8 years and the mean tumor latency was 26. 5 years. Five patients had multiple meningiomas in the irradiated field. The recurrence rate was 100% after the initial resection; 62% of patients had a second recurrence and 17% had a third recurrence. Thirtyeight percent of patients had atypical or malignant histopathological findings. The presence of progesterone receptors and low | Al-Mefty O Topsakal C Pravdenkova S Sawyer JR Harrison MJ | 2004 | 中国神经肿瘤杂志2004，2，2： | 6 |
| 5 | Muscle Wasting Is Associated With Mortality in Patients With Cirrhosis显示文摘 | Aldo J. Montano–Loza Judith Meza–Junco Carla M.M. Prado Jessica R. Lieffers Vickie E. Baracos Vincent G. Bain Michael B. Sawyer | 2012 | Clinical Gastroenterology and Hepatology2012，，2： | 5 |
| 6 | 亚致死浓度噻虫嗪对西方蜜蜂免疫相关基因表达的影响显示文摘【目的】新烟碱类农药是目前全球应用最广泛的一类农药,大量研究表明亚致死量新烟碱类农药能够影响蜜蜂的采集、学习和记忆等行为。本文主要探究亚致死浓度新烟碱类农药噻虫嗪对西方蜜蜂5种免疫相关基因:Abaecin类抗菌肽(ABA)、Hymenoptaecin类抗菌肽(HYM)、防御素(Defensin,DEF)、葡萄糖脱氢酶(Glucose dehydrogenase,GLD)和溶解酵素(Lysozyme,LYS)表达及蜜蜂个体生存的影响。【方法】(1)通过饲喂管法确定噻虫嗪对蜜蜂的经口性急性毒性;(2)对蜜蜂长期(10 d)饲喂亚致死浓度(100、10、2.2μg·kg^(-1)噻虫嗪,然后运用荧光定量PCR技术检测了蜜蜂免疫相关基因的表达变化,并统计各组蜜蜂的存活率。【结果】(1)噻虫嗪对蜜蜂经口性半数致死浓度LC_(50)=692μg·kg^(-1);(2)亚致死浓度噻虫嗪对ABA、DEF和LYS表达没有显著影响;但能够极显著的降低HYM表达水平(P<0.01);100μg·kg^(-1)噻虫嗉处理能显著增加蜜蜂GLD表达(P<0.05)。【结论】研究表明亚致死浓度噻虫嗪能够抑制蜜蜂免疫相关基因HYM表达,这对于从分子水平上探究新烟碱类农药对蜜蜂健康和生存的影响具有一定的生物学意义。 | 施腾飞 王宇飞 Sawyer Burton 齐磊 余林生 | 2017 | 应用昆虫学报2017，54，4： | 4 |
| 7 | Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair显示文摘There are intense interests in discovering pro regenerative medicine leads that can promote cardiac differentiation and regeneration,as well as repair damaged heart tissues.We have combined zebrafish embryo-based screens with cardiomyogenesis assays to discover selective small molecules that modulate heart development and regeneration with minimal adverse effects.Two related compounds with novel structures,named as Cardiomogen 1 and 2(CDMG1 and CDMG2),were identified for their capacity to promote myocardial hyperplasia through expansion of the cardiac progenitor cell population.We find that Cardiomogen acts as a Wnt inhibitor by targeting p-catenin and reducing Tcf/Lef-mediated transcription in cultured cells.CDMG treatment of amputated zebrafish hearts reduces nuclear p-catenin in injured heart tissue,increases cardiomyocyte(CM)proliferation,and expedites wound healing,thus accelerating cardiac muscle regeneration.Importantly,Cardiomogen can alleviate the functional deterioration of mammalian hearts after myocardial infarction.Injured hearts exposed to CDMG1 display increased newly formed CMs and reduced fibrotic scar tissue,which are in part attributable to the^-catenin reduction.Our findings indicate Cardiomogen as a Wnt inhibitor in enhancing injury-induced CM proliferation and heart regeneration,highlighting the values of embryo-based small molecule screens in discovery of effective and safe medicine leads. | Shuying Xie Wenbin Fu Guangju Yu Xueli Hu Kaa Seng Lai Xiangwen Peng Yating Zhou Xuejiao Zhu Ptamen Christov Leah Sawyer Terri T.Ni Gary A.Sulikowski Zhongzhou Yang Ethan Lee Chunyu Zeng Wei E.Wang Tao P.Zhong | 2020 | Journal of Molecular Cell Biology2020，12，1： | 4 |
| 8 | A long‐term nitrogen fertilizer gradient has little effect on soil organic matter in a high‐intensity maize production system显示文摘 | Kimberly H. Brown Elizabeth M. Bach Rhae A. Drijber Kirsten S. Hofmockel Elizabeth S. Jeske John E. Sawyer Michael J. Castellano | 2014 | Glob Change Biol2014，，4： | 2 |
| 9 | The spray forming of superalloys显示文摘 | Fielder H C Sawyer T S | 1987 | JOM1987，8，： | 2 |
| 10 | 噻虫啉对西方蜜蜂王浆主蛋白、免疫和记忆相关基因表达的影响显示文摘【目的】噻虫啉Thiacloprid是当今应用较为广泛的新烟碱类杀虫剂之一。研究表明亚致死剂量的噻虫啉不仅能够影响蜜蜂的采集和飞行能力,而且还能损害蜜蜂的免疫系统。本文主要探究了亚致死浓度的噻虫啉对西方蜜蜂5种王浆主蛋白基因Mrjp1,Mrjp2,Mrjp3,Mrjp4和Mrjp5 4种免疫相关抗菌肽基因Abaecin,Hymenoptaecin,Defensin1和Apidaecin以及3种记忆相关基因Pka,Creb和Nmdar1表达的影响。【方法】对蜜蜂长期饲喂含有0.2 mg/L和2 mg/L噻虫啉的糖水10 d,然后运用荧光定量PCR技术分别检测了蜜蜂王浆腺中王浆主蛋白基因以及脑部免疫和记忆相关基因的表达变化。【结果】0.2 mg/L和2 mg/L噻虫啉均能显著的抑制5种王浆主蛋白基因Mrjp1,Mrjp2,Mrjp3,Mrjp4,Mrjp5和Apidaecin的表达水平(P<0.05),而仅有2 mg/L噻虫啉处理能够能显著抑制Abaecin,Hymenoptaecin,Defensin1和Nmdar1表达(P<0.05)。不过,0.2 mg/L和2 mg/L噻虫啉处理对另外两种记忆相关基因Pka和Creb表达没有显著影响。【结论】亚致死浓度噻虫啉可能通过抑制王浆主蛋白基因的表达影响蜜蜂王浆腺的发育,而Nmdar1,Abaecin,Hymenoptaecin,Defensin1和Apidaecin的下调表达则可能预示着噻虫啉对蜜蜂记忆能力生成和免疫系统的损害。我们的研究为深入探究噻虫啉对西方蜜蜂健康影响的分子机制提供了基础。 | 施腾飞 王宇飞 Sawyer Burton 许圣云 邓全艺 章文信 余林生 | 2018 | 应用昆虫学报2018，55，4： | 2 |
| 11 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 12 | A study on the friction and wear behavior of PTFE filled with alumina nanoparticles显示文摘 | W.Gregory Sawyer Kevin D. Freudenberg Praveen Bhimaraj Linda S. Schadler | 2003 | Wear2003，，5： | 2 |
| 13 | Patterns and determinants of intra-industry trade in Asia显示文摘 | William C. Sawyer Richard L. Sprinkle Kiril Tochkov | 2010 | Journal of Asian Economics2010，，5： | 2 |
| 14 | REGULARITY ESTIMATES FOR THE OBLIQUE DERIVATIVE PROBLEM ON NON-SMOOTH DOMAINS(I)显示文摘REGULARITYESTIMATESFORTHEOBLIQUEDERIVATIVEPROBLEMONNON-SMOOTHDOMAINS(I)￥GUANPENGFEI;E.SAWYERAbstract:Theauthorsconsidertheexi... | GUAN PENGFEI E. SAWYER(Department of Mathematics and Statistics McMaster Universityt Hamilton, Olltario LSS 4KI, Canada.) | 1995 | Chinese Annals of Mathematics,Series B1995，16，3： | 2 |
| 15 | The adequacy of laboratory moniloring in patients treated with spironolactone for congestive heart failure显示文摘 | Shah KB Rao K Sawyer R | 2005 | J Am Coll Cardiol2005，46，5： | 1 |
| 16 | Decision Performance and Diversity Structure: Comparing Faultlines in Convergent, Crosscut, and Racially Homogeneous Groups 显示文摘 | SAWYER J E HOULETTE M A YEAGLEY E L | 2006 | Organizational Behavior and Human Decision Processes2006，99，1： | 1 |
| 17 | Virtu-alness and Knowledge in Teams:Managing the Love Triangle of Organizations,Individuals,And Information Technology 显示文摘 | GRIFFITH T L SAWYER J E NEALE M A | 2003 | MIS Quarterly2003，，2： | 1 |
| 18 | Chronic myeloid leukemia显示文摘 | | 1999 | N Engl J Med1999，340，17： | 1 |
| 19 | Lecithin : cholesterol acyltransferase deficiency increases atherceclerosis in the low density lipoprotein receptor and apolipoprotein E knockout mice 显示文摘 | Furbee JW Jr Sawyer JK Parks JS | 2002 | J Biol Chem2002，277，5： | 1 |
| 20 | Improved wear resistance in aluminaPTFE nanocomposites with irregular shaped nanoparticles显示文摘 | Burris D L Sawyer W G | 2006 | Wear2006，260，91： | 1 |
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