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| 1 | Fatty liver in hepatitis C patients post-sustained virological response with direct-acting antivirals显示文摘AIM To determine steatosis and fibrosis prevalence in hepatitis C patients after a sustained virological response achieved with direct-acting antivirals.METHODS Transient elastography with controlled attenuation parameter(CAP) was used to assess hepatic steatosis post-sustained virological response(SVR);the CAP technology was not available in the United States at study initiation.Liver stiffness/fibrosis was measured before and 47 wk after treatment completion.Patients with genotype 3 and patients with cirrhosis were excluded.RESULTS One hundred and one patients were included in the study.Post-SVR there were decreases from baseline in alanine aminotransferase(ALT)(63.1 to 17.8 U/L),aspartate aminotransferase(51.8 to 21.5 U/L) and fibrosis score(7.4 to 6.1 k Pa)(P < 0.05).Post-SVR,48 patients(47.5%) had steatosis on CAP;of these,6.25% had advanced fibrosis.Patients with steatosis had higher body mass index(29.0 vs 26.1 kg/m2),glucose(107.8 vs 96.6 mg/d L),ALT(20.4 vs 15.3 mg/d L),CAP score(296.3 vs 212.4 d B/m) and fibrosis score(7.0 vs 5.3 k Pa);P < 0.05.Interestingly,compared to baseline,both patients with and without steatosis had change in fibrosis score post-SVR(7.7 k Pa vs 7.0 k Pa and 7.0 k Pa vs 5.3 k Pa);alternatively,(P < 0.05) and therefore patients with steatosis continued to have clinically significant stiffness(≥ 7 k Pa).CONCLUSION Fatty liver is very common in hepatitis C virus(HCV) patients post-SVR.These patients continue to have elevated mean fibrosis score(≥ 7 k Pa) compared to those without fatty liver;some have advanced fibrosis.Long term follow up is needed to assess steatosis and fibrosis in HCV patients post-SVR. | Mazen Noureddin Micaela M Wong Tsuyoshi Todo Shelly C Lu Arun J Sanyal Edward A Mena | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 2 | A technical review on nonalcoholic fatty liver disease显示文摘 | ARUN J SANYAL A G | 2002 | Gastroenterology2002，123，： | 1 |
| 3 | Mechanisms of Disease:pathogenesis of nonalcoholic fatty liver disease显示文摘 | Sanyal A J | 2005 | Nat Clin Pract Gastroenterol Hepatol2005，2，1： | 1 |
| 4 | Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities显示文摘 | SANYAL A J CAMPBELL SARGENT C MIRSHAHI F | 2001 | Gastroenterology2001，120，5： | 1 |
| 5 | Mechanisms of Diseas: pathogenesis of nonalcoholic fatty liver disease显示文摘 | SANYAL A J | 2005 | Nat Clin Pract Gas- troenterol Hepatol2005，2，： | 1 |
| 6 | Role of RANK ligand in mediating increased bone resorption in early postmenopausal women显示文摘 | Eghbali-Fatourechi G Khosla S Sanyal A Boyle WJ Lacey DL Riggs BL | | 0，，： | 1 |
| 7 | Nonalcoholic steatohepatitis显示文摘 | Sanyal A | 2001 | Indian J Gas- troenterol2001，20，： | 1 |
| 8 | Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial显示文摘 | NEUSCHWANDER-TETRI B A LOOMBA R SANYAL A J | 2015 | Lancet2015，385，9972： | 1 |
| 9 | Endoplasmie reticulum stress and the un-folded protein response 显示文摘 | Kapoor A Sanyal AJ | 2009 | Clin Liver Dis2009，13，4： | 1 |
| 10 | End points and clini- cal trial design for nonalcoholic steatohepatitis显示文摘 | Sanyal A J Brunt EM Kleiner DE | 2011 | Hepatolo- gy2011，54，1： | 1 |
| 11 | The long-range interaction landscape of gene promoters显示文摘 | Sanyal A Lajoie B R Jain G | | 0，，7414： | 1 |
| 12 | Se- quenceanalysia of the nucleoprotein gene of Asian lineage peste des petits ruminants vaccine virus 显示文摘 | MUTHUCHELVAN D SANYAL A BALAMURUGAN V | 2006 | Vet Res Commun2006，30，8： | 1 |
| 13 | Combined effects ofinsulin-like growth factor-1 and transforming growth factor-betalon periosteal mesenchymal cells during chondrogenesis in vitro显示文摘 | Fukumoto T Sperling JW Sanyal A | 2003 | Osteoarthr Cartil2003，11，： | 1 |
| 14 | Prevention and management of gastroesopbageal varices and variceal hemorrhage in cirrhosis 显示文摘 | Garcia- Tsao G Sanyal A Grace ND | 2007 | Hepatology2007，46，3： | 1 |
| 15 | Rifaximin treatment in hepatic eneephalopathy显示文摘 | Bass NM Mullen KD Sanyal A | 2010 | N Engl J Med2010，362，12： | 1 |
| 16 | AGA technical review onnonalcohalic fatty liver dis- ease 显示文摘 | Sanyal A J | 2002 | Gastroenterology2002，，1： | 1 |
| 17 | Recent advances in non- alcholic fatty liver disease 显示文摘 | Greenfield V Cheung O Sanyal A J | 2008 | Curt Opin Gastroenterol2008，24，3： | 1 |
| 18 | Stability and stabilization of relative equilibria of dumbbell bodies in centralgravity显示文摘 | SANYAL A K SHEN J L MCCLAMROCH N H | 2005 | Journal of Guidance Control and Dynamics2005，28，5： | 1 |
| 19 | Development and degeneration of retina in rds mutant mice∶ light microscopy显示文摘 | De Ruiter A Hawkins RK | 1980 | J Comp Neurol1980，194，： | 1 |
| 20 | A randomized, prospec- tive, double blind, placebo-controlled trial of terlipressin for type 1 hepatorenal syndrome显示文摘 | Sanyal A J Boyer T Garcial-Tsao G | 2008 | Gastroenterology2008，134，5： | 1 |
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