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| 1 | 非运动症状负担、情绪和步态障碍是导致帕金森病非痴呆患者生活质量下降的最重要因素显示文摘帕金森病存在多种运动和非运动症状表现,其中非运动症状对于帕金森病患者生活质量的影响更为严重。改善帕金森病非运动症状,有助于提高患者的生活质量。既往帕金森病非运动症状研究多为单中心小样本研究,所涉及的非运动症状类型较为局限,无法全面反映非运动症状对帕金森病患者生活质量的影响。为此,该研究通过分析COPPADIS-2015研究队列来关注帕金森病患者非运动症状对其生活质量的影响。该队列是西班牙全国范围内为期5年的多中心综合观察性随访队列研究。 | 张煜(编译) Santos Garcia D de Deus Fonticoba T Suarez Castro E | 2020 | 中华医学杂志2020，100，27： | 3 |
| 2 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 3 | Stability Studies of Carbonate Pesticides and Analysis by Gas Chroma- tography with Flame Ionization and Nitrogen - phosphorus Detection 显示文摘 | SANTOS M J D RUBIO B S FERNONDEZ -TOSTADO G T | 2001 | J Chromatography2001，921，： | 1 |
| 4 | Research ethics in animal models显示文摘 | Miziara I D Magalha es A T Santos M d | 2012 | Braz J Otorhinolaryngol2012，78，2： | 1 |
| 5 | The influence of refill FSSW parameters on the microstructure and shear strength of 5042 aluminium welds显示文摘 | Tier M D Rosendo T S dos Santos J F | 2013 | Journal of Materials Processing Technology2013，213，6： | 1 |
| 6 | Layer by Layer TiO2 Thin Films and Photodegradation of Congo Red显示文摘 | Sansiviero M T C Santos D S Job A E | 2011 | J Photochem Photobiol A:Chem2011，220，1： | 1 |
| 7 | Emulsion copolymerization of styrene and n-butyl acrylate in presence of acrylic and methacrylic acids 显示文摘 | Santos A M d Mckenna T F Guillot J | 1997 | J Appl Polym Sci1997，65，： | 1 |
| 8 | Human stanniocalcin-1interacts with nuclear and cytoplasmic proteins and acts as a SUMO E3ligase显示文摘 | dos Santos M T Trindade D M Goncalves Kde A | 2011 | Mol BioSyst2011，7，1： | 1 |
| 9 | Production performance and milk composition of dairy cows fed whole or ground flaxseed with or without monensin显示文摘 | Da Silva D C Santos G T Branco A F | 2007 | J Dairy Sci2007，90，： | 1 |
| 10 | Effects of supercritical carbon dioxide on waste bananapeels for heavy metal removal显示文摘 | Albarelli J Q Rabelo R B Santos D T | 2011 | Journal of Super Critical Fluids2011，58，3： | 1 |
| 11 | Genetic deletion of the angiotensin (1 7) receptor Mas leads to glomerular hyperfiltration and microalbu minuria显示文摘 | Pinheiro S V Ferreira A J Kitten G T da Silveira K D da Silva D A Santos S H | 2009 | Kidney Int2009，75，： | 1 |
| 12 | Transcription Regulation of Abiotic Stress Responses in Rice: A Combined Action of Transcription Factors and Epigenetic Mechanisms显示文摘 | Santos A P Serra T Figueiredo D D | 2011 | OMICS: A Journal of Integrative Biology2011，15，12： | 1 |
| 13 | Microstructural evolution at the initial stages of continuous annealing of cold rolled dual-phase steel显示文摘 | Rocha R O Melo T M F Pereloma E V Santos D B | 2005 | Materials Science and Engineering A2005，391，： | 1 |
| 14 | Human bocavirus species 2and 3in Brazil显示文摘 | Santos N Peret T C Humphrey C D | 2010 | J Clin Virol2010，48，2： | 1 |
| 15 | Extraction of antioxi-dant compounds from Jabutieaba(Myrciaria cauliflora) skins: yield, com- position and economical evaluation显示文摘 | SANTOS D T VEGGI P C MEIRELES M | 2010 | J Food Eng2010，101，1： | 1 |
| 16 | Mechanistic insights of CO2-coke reaction during the regeneration step of the fluid cracking catalyst 显示文摘 | SANTOS L T D SANTOS F M SILVA R S | 2008 | Applied Catalysis A: General2008，336，12： | 1 |
| 17 | Gladius and Statolith as Tools for Age and Growth Studies of the Squid Loligo plei (Teuthida Loliginidae ) off Southern Brazil 显示文摘 | PEREZ J A A AGUIAR D C DE SANTOS J A T DOS | 2006 | Brazilian Archives of Biology and Technology2006，49，5： | 1 |
| 18 | Solid state fluorescence of a 3,4,9,10-perylenetetracarboxylic diimide derivative encapsulated in the pores of mesoporous silica MCM-41 显示文摘 | CASTRO F L D SANTOS J G FEMANDES G J T | 2007 | Micropor Mesopor Mater2007，102，13： | 1 |
| 19 | Microstructural evolution at the initial stages of continuous annealing of cold rolled dual-phase steel 显示文摘 | Rocha R O Melo T M F Pereloma E V Santos D B | 2005 | Materials Science and Engineering2005，391，： | 1 |
| 20 | Genetic and population study of a Y-linked tetranucleotide repeat DNA polymorphism with a simple non-isotopic technique显示文摘 | SANTOS F R PENA S D EPPLEN J T | 1993 | Human Genetics1993，90，6： | 1 |
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