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| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | rate of adverse events of gastroduodenal snare polypectomy for non-flat polyp is low: A prospective and multicenter study显示文摘AIM To evaluate the rate of adverse events(AEs) during consecutive gastric and duodenal polypectomies in several Spanish centers. METHODS Polypectomies of protruded gastric or duodenal polyps ≥ 5 mm using hot snare were prospectively included. Prophylactic measures of hemorrhage were allowed in predefined cases. AEs were defined and graded according to the lexicon recommended by the American Society for Gastrointestinal Endoscopy. Patients were followed for 48 h, one week and 1 mo after theprocedure. RESULTS308 patients were included and a single polypectomy was performed in 205. Only 36(11.7%) were on prior anticoagulant therapy. Mean polyp size was 15 ± 8.9 mm(5-60) and in 294 cases(95.4%) were located in the stomach. Hemorrhage prophylaxis was performed in 219(71.1%) patients. Nine patients presented AEs(2.9%), and 6 of them were bleeding(n = 6, 1.9%)(in 5 out of 6 AE, different types of endoscopic treatment were performed). Other 24 hemorrhagic episodes could be managed without any change in the outcome of the endoscopy and, consequently, were considered incidents. We did not find any independent risk factor of bleeding.CONCLUSION Gastroduodenal polypectomy using prophylactic measures has a rate of AEs small enough to consider this procedure a safe and effective method for polyp resection independently of the polyp size and location. | Henry Córdova Lidia Argüello Carme Loras Antonio Naranjo Rodríguez Faust Riu Pons Joan B Gornals David Nicolás-Pérez Xavier Andújar Murcia Luis Hernández Santos Santolaria Carles Leal Carles Pons Enrique Pérez-Cuadrado-Robles Orlando García-Bosch Michel Papo Berger José Luis Ulla Rocha Cristina Sánchez-Montes Gloria Fernández-Esparrach | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 3 | Mechanical properties of HSLA bainitic steel subjected to controlled rolling with accelerated cooling显示文摘 | RODRIGUES P C M PERELOMA E V SANTOS D B | 2000 | Materials Science and Engineering: A2000，283，： | 1 |
| 4 | Catechols from abietic acid-synthesis and evaluation as bioactive compounds显示文摘 | GIGANTE B SANTOS C SILVA A M | 2003 | Bioorganic and Medicinal Chemistry2003，11，8： | 1 |
| 5 | Formation of ultra- fine ferrite mierostructure in warm rolled and annealed C-Mn steel显示文摘 | Santos D B Bruzszek R K Rodrigues P C M | 2003 | Materials Science and Engineering: A2003，346，12： | 1 |
| 6 | Simultaneous determination of zinc,cadmium and lead in environmen-tal water samples by potentiometric stripping analysis(PSA)using multiwalled carbon显示文摘 | TARLEY C R T SANTOS V S BAETA B E L | 2009 | Journal of Hazardous Materials2009，169，13： | 1 |
| 7 | Ni-P/SiC composite coatings:the effects of particles on the electrochemical behaviour显示文摘 | MALFATTI C F FERREIRA J SANTOS C B | 2005 | Corrosion Science2005，47，： | 1 |
| 8 | Chronic stress impairs rat growth and jejunal epithelial barrier function:role of mast cells 显示文摘 | SANTOS J MICHELLE B YANG P C | 2000 | Am J Physiol Gastrointest Liver Physiol2000，278，6： | 1 |
| 9 | Retrogression and re-aging of 7075 aluminium alloy: Microstructural characterization显示文摘 | VIANA F PINTO A M P SANTO H M C LOPES A B | 1999 | Materials Processing Technology1999，9293，： | 1 |
| 10 | Ther- mal and mechanical profile of cast films from waterborne polyurethanes based on polyether block copolymers 显示文摘 | SANTOS C C DELPECH M C COUTINHO F M B | 2009 | Journal of Materials Science2009，44，5： | 1 |
| 11 | Catechols from abietic acid synthesis and evaluation as bioactive compounds 显示文摘 | Gigante B Santos C Silva A M | 2003 | Bioorg Med Chem2003，11，8： | 1 |
| 12 | Oxidation of CO,ethanol and toluene over TiO2 supported noble metal catalysts显示文摘 | SANTOS V P CARABINEIRO S A C TAVARES P B PEREIRA M F R ORFAO J J M FIGUEIREDO J L | | 0，，： | 1 |
| 13 | Proteome changes in Oncidium sphacelatum ( Orchidaee- ae) at different trophic stages of symbiotic germination显示文摘 | VALADARES R B S PEROTTO S SANTOS E C | 2014 | Mycorrhiza2014，24，5： | 1 |
| 14 | Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment显示文摘 | Santos L H M L M Araújo A N Fachini A Pena A Delerue-Matos C Montenegro M C B S M | | 0，，： | 1 |
| 15 | Catechols from abietic acid:synthesis and evaluation as bioactive compounds显示文摘 | GIGANTE B SANTOS C SILVA A M | 2003 | Bioorganic&Medicinal Chemistry2003，11，8： | 1 |
| 16 | Amorphous cellulose gel as a fat substitute in fermented sausages 显示文摘 | CAMPAGNOL P C B DOS Santos B A WAGNER R | 2012 | Meat Science2012，90，1： | 1 |
| 17 | Clustering Fetal Heart Rate Tracings by Compression显示文摘 | Santos C C Bernardes J Vitanyi P M B | 2006 | CBMS2006，，7： | 1 |
| 18 | Kinetic analysis of the bisubstrate cysteine desulfurase SufS from Bacillus subtilis 显示文摘 | Selbaeh B Earles E Dos Santos P C | 2010 | Biochemistry2010，49，40： | 1 |
| 19 | Determination of the triterpenoid, betulinic acid, in doliocarpus schottianus by HPLC显示文摘 | De B H Santos C A Espindola A P | 2002 | Phytochem Anal2002，13，2： | 1 |
| 20 | Catechols from abietic acid: synthesis and evaluation as bioactive compounds显示文摘 | Gigante B Santos C SilvaAM | 2003 | Bioorganic &MedicinalChemistry2003，11，8： | 1 |
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