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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Terrestrial biosphere carbon fluxes quantification of sinks and sources of CO2显示文摘 | Sampson R N Apps M Brown S | 1993 | Water Air and Soil Pollution1993，70，： | 1 |
| 3 | Terrestrial biosphere carbon fluxes quantification of sinks and sources of CO2 显示文摘 | Sampson R N Apps M Brown S | 1993 | Water Air and Soil Pollution1993，70，14： | 1 |
| 4 | Do US emergency medicine residency programs provide adequate training for bioterrorism 显示文摘 | Pesik N Keim M Sampson TR | 1999 | Ann Emerg Med1999，34，2： | 1 |
| 5 | Safety and tolerability of an antiasthma herbal formula (ASHMI) in adult subjects with asthma:a randomized,double-blinded,placebo-controlled,dose-escalation phase Ⅰ study显示文摘 | Kelly-Pieper K Patil SP Busse P Yang N Sampson H Li XM Wisnivesky JP Kattan M | | 0，，07： | 1 |
| 6 | Workshop summary statement-terrestrial biospheric carbon fluxes-quantification ofsinks and sources of C02 显示文摘 | Sampson R N Apps M Brown S | 1993 | Water Air and Soil Pollution1993，70，14： | 1 |
| 7 | Linking organic matter deposition and iron mineral transformations to ground- water arsenic levels in the Mekong delta, Cambodia显示文摘 | Quicksall A N Bostick B C Sampson M L | 2008 | Ap- plied Geochemistry2008，23，： | 1 |
| 8 | Do us emergency medicine residency programs provide adequate training far biotemorism? 显示文摘 | Pesik N Keim M Sampson TR | 1999 | Ann Emerg Med1999，34，2： | 1 |
| 9 | Plasma F2 isoprostanes:direct evidence of increased free radical damage during acute hyperglycemia in type 2 diabetes 显示文摘 | SAMPSON M J GOPAUL N DAVIES I R | 2002 | Diabetes Care2002，25，： | 1 |
| 10 | Elevated matrix metallopmteinase-2 and -3 production from human diabetic dermal fibroblasts 显示文摘 | Wall S J Sampson M J Levell N | 2003 | Br J Dermatol2003，149，1： | 1 |
| 11 | Elevated matrix met-alloproteinase-2 and -3 production from human diabetic dermal fibroblasts 显示文摘 | Wall SJ Sampson M J Levell N | 2003 | Br J Dermatol2003，149，1： | 1 |
| 12 | “Stockholm syndrome” : psychiatric diagnosis or urban myth?显示文摘 | Namnyak M Tufton N Szekely R Toal M Worboys S ’Sampson EL | 2008 | Acta Psychiatrica Scandinavica2008，117，1： | 1 |
| 13 | Terrestrial biospheric carbon fluxes quantification of sinks and sources of CO2显示文摘 | SAMPSON R N APPS M | 1993 | Water Air & Soil Pollution1993，70，： | 1 |
| 14 | Involvement of chitinases of Bacillus thudngiensis during pathogenesis in insects显示文摘 | SAMPSON M N GOODAY G W | 1998 | Microbiology1998，144，8： | 1 |
| 15 | Exploring retinal and functional markers of diabetic neuropathy显示文摘 | M Shahidi A Sampson GP Pritchard N | 2010 | Clin Exp Optom2010，93，5： | 1 |
| 16 | Terrestrial biosphere carbon fluxes quantification of sinks and sources of CO2显示文摘 | Apps M Brown S | 1993 | Water Air and Soil Pollution1993，70，： | 1 |
| 17 | Mental disorders,comorbidity and suicidal behavior : Results from the National ComorbiditySurvey Replication显示文摘 | Nock M K Hwang I Sampson N A | 2010 | Molecular psychiatry2010，15，8： | 1 |
| 18 | Terrestrial biosphere carbon fluxes quantification of sinks and sources of CO2显示文摘 | Sampson R N Apps M Brown S | 1993 | Water Air and Soil Pollution1993，70，： | 1 |
| 19 | Involvement of chitinases of Bacillus thuringiensis during pathogenesis in insects显示文摘 | SAMPSON M N GOODAY G W | 1998 | Microbiology1998，144，8： | 1 |
| 20 | Elevatedmatrix metalloproteinase-2 and-3 production from humandiabetic dermal fibroblasts 显示文摘 | WALL S J SAMPSON M J LEVELL N | 2003 | Br J Dermatol2003，149，1： | 1 |
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