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| 1 | Signaling pathways that regulate axon regeneration显示文摘Neurons in the mammalian central nervous system (CNS) cannot regenerate axons after injury. in contrast, neurons in the mammalian peripheral nervous system and in some non-mammalian models, such as C. elegans and Drosophila, are able to regrow axons. Understanding the molecular mechanisms by which these neurons support axon regeneration will help us find ways to enhance mammalian CNS axon regeneration. Here, recent studies in which signaling pathways regulating naturally-occurring axon regeneration that have been identified are reviewed, focusing on how these pathways control gene expression and growth-cone function during axon regeneration. | Saijilafu Bo-Yin Zhang Feng-Quan Zhou | 2013 | Neuroscience Bulletin2013，29，4： | 6 |
| 2 | Decoding epigenetic codes: new frontiers in exploring recovery from spinal cord injury显示文摘Spinal cord injury that results in severe neurological disability is often incurable.The poor clinical outcome of spinal cord injury is mainly caused by the failure to reconstruct the injured neural circuits.Several intrinsic and extrinsic determinants contribute to this inability to reconnect.Epigenetic regulation acts as the driving force for multiple pathological and physiological processes in the central nervous system by modulating the expression of certain critical genes.Recent studies have demonstrated that post-SCI alteration of epigenetic landmarks is strongly associated with axon regeneration,glial activation and neurogenesis.These findings not only establish a theoretical foundation for further exploration of spinal cord injury,but also provide new avenues for the clinical treatment of spinal cord injury.This review focuses on the epigenetic regulation in axon regeneration and secondary spinal cord injury.Together,these discoveries are a selection of epigenetic-based prognosis biomarkers and attractive therapeutic targets in the treatment of spinal cord injury. | Bo-Yin Zhang Peng-Yu Chang Qing-San Zhu Yu-Hang Zhu Saijilafu | 2020 | Neural Regeneration Research2020，15，9： | 3 |
| 3 | mTOR signaling pathway differently regulates central and peripheral axon regeneration显示文摘 | Ziwei Huang Weihua Wang Jinjin Ma Bin Li Jianquan Chen Huilin Yang Saijilafu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，8： | 2 |
| 4 | MicroRNA- 138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration显示文摘 | Lru C M WANG R Y SAIJILAFU | 2013 | Genes & Development2013，27，13： | 1 |
| 5 | MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration 显示文摘 | Liu CM Wang RY Saijilafu | 2013 | GenesDev2013，27，13： | 1 |
| 6 | Growing the growth cone:remodel-ing the cytoskeleton to promote axon regeneration显示文摘 | Hur EM Saijilafu Zhou FQ | | 0，，： | 1 |
| 7 | MicroRNA-138 and SIRTI form a mutual negative feedback loop to regulate mam- malian axon regeneration 显示文摘 | Liu CM Wang RY Saijilafu | 2013 | Genes Dev2013，27，13： | 1 |
| 8 | Growing the growth cone:re- modeling the cytoskeleton to promote axon regeneration 显示文摘 | Hur EM Saijilafu Zhou FQ | 2012 | Trends Neurosci2012，35，5： | 1 |
| 9 | Growing the growth cone:remodeling the cytoskeleton to promote axon regeneration显示文摘 | HUR E M SAIJILAFU ZHOU F Q | 2012 | Trends Neurosci2012，35，3： | 1 |
| 10 | Repair of peripheral nerve defect by direct gradual lengthening of the distal nerve stump in rats: cellular reaction 显示文摘 | Yamada Y Nishiura Y Saijilafu | 2009 | Scand J Plast Reconstr Surg Hand Surg2009，43，6： | 1 |
| 11 | MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration 显示文摘 | Liu CM Wang RY Saijilafu | 2013 | Genes Dev2013，27，13： | 1 |
| 12 | Glycogen synthase kinase 3: a crucial regulator of axotomy-induced axon regeneration显示文摘Following nerve injury,axonal disconnection in neurons usually results in persistent functional deficits,such as paralysis.However,axons in the adult mammalian central nervous system (CNS) have very limited regenerative ability.Understanding the molecular mechanism of controlling axon regeneration can provide idea for the design of effective therapeutic interventions for CNS injury,such as spinal cord injuries.Efficient axonal regeneration is achieved via gene expression in the neuronal soma,axonal transport of raw materials along the shaft,and membrane and cytoskeleton assembly at the nerve growth cone.Each process is delicately regulated by spatial-temporal controlled signaling pathways that target distinct effectors.Gene expression in the neuronal soma,especially of transcription factors,is often activated immediately following nerve injury.Injury signals at distal axons are interpreted and transmitted back to the soma,initiating a stream of gene expression events which positively regulate subsequent axonal regeneration.Over the past few decades,extensive studies have identified many regeneration-associated genes,including CREB,nuclear factor of activated T-cells,protein 53,Sprr1a,c-Jun,Smad1,activating transcription factor 3,signal transducer and activator of transcription 3,SRF,Sox11,and Kruppel-like factors.However,we know far less about how the coordinated expression of these regeneration-associated genes is regulated during axonal regeneration.Indeed,it is possible that they are regulated by a single common upstream regulator.If so,identification of this upstream regulator will provide us with an invaluable target for the development of more effective treatments for traumatic nerve injuries.Adult dorsal root ganglion (DRG) neurons represent a favorable medium in which to study the molecular mechanisms controlling intrinsic neuronal axon growth ability.Axotomy of the peripheral branch of a DRG neuron,known as a “conditioning lesion”,has been well-documented to greatly accelerate axonal growth both in vivo and in vitro,by enhancing the neuronal intrinsic growth potential.Enhancement of the growth state is thought to be mediated by a transcription-dependent axonal growth system that controls the expression of a number of regeneration-associated genes. | Jinlian Liu Qing Zhou Chaoqun Liu Chunfeng Liu Saijilafu | 2020 | Neural Regeneration Research2020，15，5： | 1 |
| 13 | Repair of peripheral nerve defect by direct gradual lengthening of the distal nerve stump in rats: cellular reaction 显示文摘 | Yamada Y Nishiura Y Saijilafu | 2009 | Scand J Plast Reconstr Surg Hand Surg2009，43，6： | 1 |
| 14 | Growing the growth cone : remode- ling the cytoskeleton to promote axon regeneration 显示文摘 | Hur EM Saijilafu Zhou FQ | 2012 | Trends Neurosci2012，35，3： | 1 |
| 15 | PI3K-GSK3 signalling regulates mammalian axon regeneration by inducing the ex- pression of Smadl 显示文摘 | Saijilafu Hur EM Liu CM | 2013 | Nat Commun2013，4，： | 1 |
| 16 | Gradual stretching of the proximal nerve stump induces the growth of regenerating sprouts in rats显示文摘 | Saijilafu Nishiura Y Hara Y | 2008 | J Orthop Res2008，26，7： | 1 |
| 17 | The intrinsic axon regenerative properties of mature neurons after injury显示文摘Thousands of nerve injuries occur in the world each year.Axon regeneration is a very critical process for the restoration of the injured nervous system’s function.However,the precise molecular mechanism or signaling cascades that control axon regeneration are not clearly understood,especially in mammals.Therefore,there is almost no ideal treatment method to repair the nervous system’s injury until now.Mammalian axonal regeneration requires multiple signaling pathways to coordinately regulate gene expression in soma and assembly of the cytoskeleton protein in the growth cone.A better understanding of their molecular mechanisms,such as axon regeneration regulatory signaling cascades,will be helpful in developing new treatment strategies for promoting axon regeneration.In this review,we mainly focus on describing these regeneration-associated signaling cascades,which regulate axon regeneration. | Chunfeng Liu Jinlian Liu Chaoqun Liu Qing Zhou Yaodong Zhou Boyin Zhang Saijilafu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，1： | 1 |
| 18 | MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration 显示文摘 | Liu CM Wang RY Saijilafu | 2013 | Genes Dev2013，27，13： | 1 |
| 19 | Growing thegrowth cone: remodeling the cytoskeleton to promoteaxon regeneration 显示文摘 | HUR E M SAIJILAFU ZHOU F Q | 2012 | Trends Neurosci2012，35，3： | 1 |
| 20 | Heel pain caused by os subcalcis:A case report显示文摘BACKGROUND The accessory bones are common bone variations around the feet and ankles,which usually originate from nonunion of the secondary ossification center adjacent to the main bone mass,and most of them remain asymptomatic.Os subcalcis is an accessory bone at the plantar aspect of the calcaneus,which is located just posterior to the insertion of the plantar fascia.Focal bone formation at the calcaneal plantar pole with heel pain has rarely been reported.CASE SUMMARY A 55-year-old man presented to our clinic with left plantar heel pain and a progressive swelling for 8 years.X-ray,computer tomography and magnetic resonance imaging showed a large os subcalcison the plantar side of the calcaneus,located at the insertion of the plantar fascia.He underwent surgical excision of the lesion.Microscopically the bony trabeculae were intermingled with fat and covered with cartilage.CONCLUSION This is a rare case with accessory os subcalcis leading to heel pain.It highlights the awareness of os subcalcis and helps avoid future misdiagnosis of heel pain. | Saijilafu Suo-Yuan Li Xiao Yu Zhi-Qiang Li Guang Yang Jing-Huan Lv Guang-Xiang Chen Ren-Jie Xu | 2022 | World Journal of Clinical Cases2022，10，16： | 0 |
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