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| 1 | 5-Azacytidine induces changes in electrophysiological properties of human mesenchymal stem cells显示文摘以前,导出髓的干细胞(MSC ) 与不确定的脱氧核糖核酸甲基转移酶禁止者 5-azacytidine 对待的老鼠骨头被报导区分 intocardiomyocytes。现在的学习的目的是在从健康骨髓施主获得的人的单音的原子房间调查类似的区别策略的效率。After1-3 段落,文化为 24 h 暴露于到 6 星期进一步的文化跟随的 5-azacytidine (3 mciroM ) 。药处理没导致 myogenic 标记 MyoD 或心脏的 markersNkx2.5 和 GATA-4 的表示并且没在后续期间产出跳动的房间。在补丁夹钳实验,近似 10-15% 对待,未经治疗的房间展出了 L 类型 Ca (2+) 水流。几乎所有房间表面地出现了修正快速或慢的激活动力学的 K (+) 水流。在与匹配时间的控制相比在 6 星期处理以后加倍的 +60 mV 意味着当前的振幅。对待的房间的 Membranecapacitance 比在在处理以后的 controls2 星期内显著地大并且在 6 个星期以后仍然保持高。为 K (+) 隧道 Kv1.1, Kv1.5, Kv2.1, Kv4.3 和 KCNMA1 并且为 Ca (2+) 隧道 Ca (v) 的 mRNAs 的表示层次 1.2 没被 5-azacytidine 影响。在以前显示出禁止 hMSC 的快速或慢慢地激活的 K (+) 水流的集中的 Treatmentwith 钾隧道块 ers tetraethylammonium 和 clofilium 禁止了这些房间的增长。我们的结果建议尽管有进 cardiomyocytes 的 hMSC 的区别的缺席,有 5-azacytidine 的处理在当前的密度引起了深刻变化。 | Bartosz Balanal Cecilia Nicoletti Ihor Zahanich Eva M Graf Torsten Christ Sabine Boxberger Ursula Ravens | 2006 | Cell Research2006，16，12： | 20 |
| 2 | Global kinematics of tectonic plates and subduction zones since the late Paleozoic Era显示文摘Detailed global plate motion models that provide a continuous description of plate boundaries through time are an effective tool for exploring processes both at and below the Earth's surface. A new generation of numerical models of mantle dynamics pre-and post-Pangea timeframes requires global kinematic descriptions with full plate reconstructions extending into the Paleozoic(410 Ma). Current plate models that cover Paleozoic times are characterised by large plate speeds and trench migration rates because they assume that lowermost mantle structures are rigid and fixed through time. When used as a surface boundary constraint in geodynamic models, these plate reconstructions do not accurately reproduce the present-day structure of the lowermost mantle. Building upon previous work, we present a global plate motion model with continuously closing plate boundaries ranging from the early Devonian at 410 Ma to present day.We analyse the model in terms of surface kinematics and predicted lower mantle structure. The magnitude of global plate speeds has been greatly reduced in our reconstruction by modifying the evolution of the synthetic Panthalassa oceanic plates, implementing a Paleozoic reference frame independent of any geodynamic assumptions, and implementing revised models for the Paleozoic evolution of North and South China and the closure of the Rheic Ocean. Paleozoic(410-250 Ma) RMS plate speeds are on average ~8 cm/yr, which is comparable to Mesozoic-Cenozoic rates of ~6 cm/yr on average.Paleozoic global median values of trench migration trend from higher speeds(~2.5 cm/yr) in the late Devonian to rates closer to 0 cm/yr at the end of the Permian(~250 Ma), and during the Mesozoic-Cenozoic(250-0 Ma) generally cluster tightly around ~1.1 cm/yr. Plate motions are best constrained over the past 130 Myr and calculations of global trench convergence rates over this period indicate median rates range between 3.2 cm/yr and 12.4 cm/yr with a present day median rate estimated at~5 cm/yr. For Paleozoic times(410-251 Ma) our model results in median convergence rates largely~5 cm/yr. Globally,~90% of subduction zones modelled in our reconstruction are determined to be in a convergent regime for the period of 120-0 Ma. Over the full span of the model, from 410 Ma to 0 Ma,~93% of subduction zones are calculated to be convergent, and at least 85% of subduction zones are converging for 97% of modelled times. Our changes improve global plate and trench kinematics since the late Paleozoic and our reconstructions of the lowermost mantle structure challenge the proposed fixity of lower mantle structures, suggesting that the eastern margin of the African LLSVP margin has moved by as much as ~1450 km since late Permian times(260 Ma). The model of the plate-mantle system we present suggests that during the Permian Period, South China was proximal to the eastern margin of the African LLSVP and not the western margin of the Pacific LLSVP as previous thought. | Alexander Young Nicolas Flament Kayla Maloney Simon Williams Kara Matthews Sabin Zahirovic R.Dietmar Müller | 2019 | Geoscience Frontiers2019，10，3： | 10 |
| 3 | 儿童期肥胖、成年期肥胖和心血管风险因子显示文摘过去30年,儿童超重或肥胖的发生率明显增加[1]。儿童期肥胖是死亡率增加的预测因子,这主要是由于儿童期肥胖可导致心血管疾病发生率增加。相关的预测研究提示"肥胖流行症"可能改变目前心血管疾病死亡率下降的趋势,使现今儿童的寿命缩短。 | Juonala M Magnussen CG Berenson GS Venn A Burns TL Sabin MA Srinivasan SR Daniels SR Davis PH Chen W Sun C Cheung M Viikari JS Dwyer T Raitakari OT 叶鹏 | 2012 | 中华高血压杂志2012，20，1： | 6 |
| 4 | Spontaneous elimination of hepatitis C virus infection: A retrospective study on demographic, clinical, and serological correlates显示文摘AIM: To fi nd correlates to spontaneous clearance of hepatitis C virus (HCV) infection, this study compared individuals with self-limited and chronic infection with regard to clinical, demographic, and serological pa-rameters. METHODS: Sixty-seven anti-HCV positive and repeatedly HCV RNA negative individuals were considered to have resolved HCV infection spontaneously. To determine the viral genotype these patients had been infected with HCV serotyping was performed. For comparison reasons, 62 consecutive patients with chronic hepatitis C were enrolled. Cases and controls were compared stratifi ed for age and sex. RESULTS: Retrospective analysis showed (1) a lower humoral reactivity to HCV in patients with self-limited compared to chronic HCV-infection and (2) that younger age, history of iv drug use, and acute/post-acute hepatitis A or B co-infections, but not viral genotypes, are independent correlates for spontaneous HCV clearance. CONCLUSION: The stronger humoral reactivity to HCV in patients with persistent infections and in those with a history of iv drug use is supposed to be due to continuous or repeated contact(s) to the antigen. Metachronous hepatitis A or hepatitis B infections might favor HCV clearance. | Perdita Wietzke-Braun Larissa Bettina Mnhardt Albert Rosenberger Angela Uy Giuliano Ramadori Sabine Mihm | 2007 | World Journal of Gastroenterology2007，13，31： | 2 |
| 5 | The accuracy of volumetric bone density measurements in dual X-ray absorptiometry 显示文摘 | SABIN M A BLAKE G M MACLAUGHLIN BLACK S M | 1995 | Calcif Tissue Int1995，56，3： | 1 |
| 6 | Paralytic syndromes associated with non-inflammatory cytoplasmic or nuclear neuropathology: acute paralytic disease in Mexican children, neuropathologically distinguish- able from Landry-Guillain-Barre'syndrome显示文摘 | Ramos-Alvarez M Bessudo L Sabin A B | 1969 | JAMA1969，207，： | 1 |
| 7 | Behavior of recursive division suriace near extraordinary points 显示文摘 | Doo D Sabin M | 1978 | Computer-Aided Design1978，10，6： | 1 |
| 8 | Preclinical efficacy and safety of rVIII-SingleChain (CSL627), a novel recombinant single-chain factor VIII显示文摘 | Sabine B. Zollner Elmar Raquet Jochen Müller-Cohrs Hubert J. Metzner Thomas Weimer Ingo Pragst Gerhard Dickneite Stefan Schulte | 2013 | Thrombosis Research2013，，： | 1 |
| 9 | 控制技术的自我超越——Namur大会报道:实现高效的过程管理显示文摘尽管在开会之前,由于全球性经济危机传来了一些令人吃惊的回绝消息,但是本年度的德国测量与控制标准委员会Namur大会的与会者仍然达到了450人之多。本次Namur大会,主要针对如何提高流程工业企业的过程管理问题进行了讨论。 | Sabine Mühlenkamp | 2009 | 流程工业2009，，4： | 1 |
| 10 | Acombined system of lagoon and constructed wetland for an effective wastewater treatment显示文摘 | Christian R S Sabine W and Arnutf M | 2003 | Water Research2003，37，9： | 1 |
| 11 | Long-term urban particulate air pollution,traffic noise,and arterial blood pressure 显示文摘 | Kateryna F Susanne M Sabine H | 2011 | Environ Health Perspect2011，119，： | 1 |
| 12 | Convergence theory for fuzzy C-means:counter-examples and repairs显示文摘 | BEZEDEK J C HATHAWAY R J SABIN M J | 1987 | IEEE Trans on System Man and Cybernetics-Parts B:Cybernetics1987，17，5： | 1 |
| 13 | Behavior of recursive division surfaces near extraordinary points显示文摘 | DOO D SABIN M | 1978 | Computer-Aided Design1978，10，6： | 1 |
| 14 | Particle-mediated gene therapy of wounds显示文摘 | Jeffrey M D Thomas K Sabine A E | 2002 | Wound Rep and Reg2002，8，6： | 1 |
| 15 | Effect of discontinuation of long-term growth hormone treatment on carbohydrate metab- olism and risk factors for cardiovascular disease in girls with turner syndrome 显示文摘 | Yvonne KP Sabine M Theo S | 2002 | J Clin Endocrinol Metab2002，87，12： | 1 |
| 16 | Prognosis of HIV-l-infected patients up to 5 years after initiation of HAART: collaborative a- nalysis of prospective studies显示文摘 | May M Sterne JA Sabin C | 2007 | AIDS2007，21，9： | 1 |
| 17 | Supported gold nanoparticles:In-depth catalyst characterization and application in hydrogenation and oxidation reactions显示文摘 | SABINE S MARTIN L CHRISTIAN M | 2002 | Catal Today2002，72，： | 1 |
| 18 | Saturated fatty acids induce insulin resistance in human podocytes : implications for dia- betic nephropathy显示文摘 | LENNON R PONS D SABIN M A | 2009 | Nephrol Dial Transplant2009，24，11： | 1 |
| 19 | Dieleman, Antipsychotics and the Risk of Sudden Cardiac Death 显示文摘 | Sabine M Straus JM Gyse'le S | 2004 | Arch Intern Med2004，164，12： | 1 |
| 20 | Usefulness of measurement of fibrinogen, D-di- mer,D-dimer/fibrinogen ratio,C reactive protein and erythrocyte sedimentation rate to assess the patho- physiology and mechanism of ischaemic stroke显示文摘 | Alvarez Perez FJ Castelo Branco M Alvarez Sabin J | 2011 | J Neurol Neurosurg Psychiatry2011，82，9： | 1 |
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