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| 1 | Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine显示文摘With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies.Despite numerous setbacks,efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases.It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies.There has been a long-lasting interest in using viral vectors,especially adenoviral vectors,to deliver therapeutic genes for the past two decades.Among all currently available viral vectors,adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types.The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development.In fact,among over 2000 gene therapy clinical trials approved worldwide since 1989,a significant portion of the trials have utilized adenoviral vectors.This review aims to provide a comprehensive overview on the characteristics of adenoviral vectors,including adenoviral biology,approaches to engineering adenoviral vectors,and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment,vaccination and regenerative medicine.Current challenges and future directions regarding the use of adenoviral vectors are also discussed.It is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine. | Cody S.Lee Elliot S.Bishop Ruyi Zhang Xinyi Yu Evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu Sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He | 2017 | Genes & Diseases2017，4，2： | 19 |
| 2 | 3-D bioprinting technologies in tissue engineering and regenerative medicine:Current and future trends显示文摘Advances in three-dimensional(3D)printing have increased feasibility towards the synthesis of living tissues.Known as 3D bioprinting,this technology involves the precise layering of cells,biologic scaffolds,and growth factors with the goal of creating bioidentical tissue for a variety of uses.Early successes have demonstrated distinct advantages over conventional tissue engineering strategies.Not surprisingly,there are current challenges to address before 3D bioprinting becomes clinically relevant.Here we provide an overview of 3D bioprinting technology and discuss key advances,clinical applications,and current limitations.While 3D bioprinting is a relatively novel tissue engineering strategy,it holds great potential to play a key role in personalized medicine. | Elliot S.Bishop Sami Mostafa Mikhail Pakvasa Hue H.Luu Michael J.Lee Jennifer Moriatis Wolf Guillermo A.Ameer Tong-Chuan He Russell R.Reid | 2017 | Genes & Diseases2017，4，4： | 10 |
| 3 | The McMaster Approach to Families: theory, assessment, treatment and research显示文摘 | Ivan W.Miller Christine E.Ryan Gabor I.Keitner Duane S.Bishop Nathan B.Epstein | 2008 | Journal of Family Therapy2008，，2： | 2 |
| 4 | The McMaster Approach to Families: theory, assessment, treatment and research显示文摘 | Ivan W.Miller Christine E.Ryan Gabor I.Keitner Duane S.Bishop Nathan B.Epstein | 2008 | Journal of Family Therapy2008，，2： | 1 |
| 5 | 钯涂(镀)层的分析显示文摘采用化学镀钯得到的纯钯(Pd)适用于软接触开关、电镀通孔的波峰焊和精细与超精细节距表面安装等领域上。钯表面涂(镀)层对于印制电路板(PCB)上单一镀层厚度于所有的应用领域中都可得到令人满意成本要求。 | P.Seto J.Evans S.Bishop 丁志廉 | 1999 | 印制电路信息1999，0，9： | 0 |
| 6 | Neutron and Alpha Structure in Neutron Deficient Nuclei in Astrophysics显示文摘The paper includes discussions on the important role of neutron and alpha configurations in proton-rich nuclei in nuclear astrophysics in terms of nucleosynthesis under extremely high-temperature hydrogenburning conditions. The νp-process, which is supposed to take place at the very early epoch of type II supernovae, has considerable neutrons and alphas together with protons. The alpha-induced reactions on proton-rich unstable nuclei in the light mass regions is expected to play a crucial role, but very few of them were investigated well yet because of the experimental difficulties. Specifically, I report our recent experimental effort for the breakout process from the pp-chain region,~7Be(α, γ)^(11)C(α,p)^(14)N under the νp-process. The neutron-induced reactions on proton-rich nuclei, which is even more a challenging subject, were investigated previously for very few nuclei. One possible experimental method is the Trojan Horse Method(THM). We successfully have applied THM to the ^(18)F(n,α)^(14)N reaction study with an unstable beam of ^(18)F. | S.Kubono 何建军 H.Yamaguchi D.M.Kahl S.Hayakawa T.Teranishi S.Cheribini M.Gulino Y.K.Kwon T.Hashimoto Y.Wakabayashi N.Iwasa S.Kato T.Komatsubara D.N.Binh L.H.Khiem N.N.Duy T.Kawabata C.Spitaleri G.G.Rapisarda M.La Cognata L.Lamia R.G.Pizzone S.Romano A.Coc N.de Sereville F.Hammache G.Kiss S.Bishop | 2016 | 原子核物理评论2016，33，2： | 0 |
| 7 | 用于软接触开关和高密度SMT组装的钯表面涂覆层显示文摘1 概述本文论述了采用化学镀工艺形成的纯钯表面涂覆层,预期可用于软接触开关。镀通孔的波峰焊接、表面安装波峰焊接和用于精细节距与甚精细节距的表面安装焊膏再流焊等。这种钯镀层具有明显的成本效应。相同的 PWB 上仅以单一钯层厚度就可满足上述所有应用领域的要求。对于 PWB 组装业务来说,化学镀钯的表面涂覆层还是相当新的技术。但是。 | P.Seto J.Evans S.Bishop 丁志廉 | 1999 | 印制电路信息1999，0，7： | 0 |
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