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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Simulation of the performance of electrical capacitance tomography for muasurement of dense phase pneumatic conveying显示文摘 | K L Ostrowski S P Luke R A Williams | 1997 | Chemical Engineering Journal1997，，6： | 1 |
| 3 | Industrial applications of electrical tomography to solid conveying显示文摘 | LUKE S P WILLIAMS R A | 1997 | Measurement & Control1997，，30： | 1 |
| 4 | Biasing coevolutionary search for optimal multiagent behaviors显示文摘 | PANAIT L LUKE S WIEGAND R P | 2007 | IEEE Transactions on Evolutionary Computation2007，10，6： | 1 |
| 5 | Economic analysis in the MRO in- dustry: an options approach 显示文摘 | LUKE T M CHAN S P | 2004 | The Engineering Econo- mist2004，49，5： | 1 |
| 6 | Simulation of the performance of electrical capacitance tomography for measurement of dense phase pneumatic conveying显示文摘 | OSTROWSKI K L LUKE S P WILLIAMS R A | 1997 | Chemical Engineering Journal1997，68，23： | 1 |
| 7 | Iron overload and heart fibrosis in mice deficient for both β2- microglobulin and Ragl 显示文摘 | MANUELA M S MARIA D S LUKE H P | 2000 | Am J Pathol2000，157，6： | 1 |
| 8 | Real time visualisation and analysis of dense phase powder conveying显示文摘 | Ostrowski K Luke S P Bennett M A | 1999 | Power Technology1999，102，1： | 1 |
| 9 | Real time visualisation and analysis of dense phase powder bonveying显示文摘 | Ostrowski K Luke S P Bennett M A | 1999 | Powder Technology1999，，102： | 1 |
| 10 | Application of capacitance electrical tomography for on-line and off-line analysis of flow pattern in horizontal pipeline of pneumatic conveyer 显示文摘 | Ostrowski K L Luke S P Bennett M A | 2000 | Chemical Engineering Journal2000，，77： | 1 |
| 11 | Learning symbolic models of stochastic domains 显示文摘 | Hanna M P Luke S Z Leslie P K | 2007 | Journal of Artificial Intelligence Re- search2007，29，1： | 1 |
| 12 | Application of conjugate harmonics to electrical process tomography 显示文摘 | Ostrowski K L Luke S P Williams R A | 1996 | Meas Sci Technol1996，7，： | 1 |
| 13 | Simulation of the performance of electrical capacitance tomography for measurement of dense phase pneumatic conveying 显示文摘 | OSTROWSKI K L LUKE S P WILLIAMS R A | 1997 | Chemical Engineering Journal1997，6，： | 1 |
| 14 | Real time visualization and analysis of dense phase powder conveying 显示文摘 | Ostrowski K L Luke S P Bennet M A Wilhams R A | 1999 | Powder Technology1999，102，1： | 1 |
| 15 | Simulation of the performance of electrical capacitance topography for measurement of dense phase pneumatic conveying显示文摘 | OSTROWSKI K L LUKE S P WILLIAMS R A | 1997 | Chemical Engineering Journal1997，68，23： | 1 |
| 16 | Economic analysis in the MRO industry: An options approach 显示文摘 | Luke T M Chan S P | 2004 | The Engineering Economist2004，49，1： | 1 |
| 17 | Denosine kinase deficiency in associated with developmental abnormalities and reduced transmethylation显示文摘 | Barbara A M Yvonne Y S Mike S A Jamie D S,Luiz A P,Margarita I T,Peter S S,Elizabeth A W,Luke M M,Conrad W A | | 0，，： | 1 |
| 18 | Estimation of Specific Salivary Enzymatic Biomarkers inIndividuals with Gingivitis and Chronic Periodontitis:A Clinical and Biochemical Study显示文摘 | Roji Luke S Nubesh Khan P Safar Iqbal et al | 2015 | Journal of International Oral Health2015，7，9： | 1 |
| 19 | Application of capacitance tomogaphy to gas-solid flows显示文摘 | DYAKOWSKI T LUKE S P OSTROWSKI K L | 1997 | Chem Eng Sci1997，，52： | 1 |
| 20 | Real time visualisation and analysis of dense phase powder convey- ing显示文摘 | Ostrowski K Luke S P Bennett M A | 1999 | PowderTechnology1999，102，1： | 1 |
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