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    题名 作者 年代 出处 被引量
1High-frequency magnetic stimulation attenuates beta-amyloid protein 1-42 neurotoxicity in organotypic hippocampal slices显示文摘Repetitive transcranial magnetic stimulation (rTMS) has been utilized as a therapeutic tool for neurodegenerative disorders including Alzheimer’s disease.However,the precise mechanisms of its clinical effects remain unknown.β-amyloid (Aβ) exhibits direct neurotoxic effects and is closely related to neuronal degeneration in Alzheimer’s disease.Therefore,it has been hypothesized that the neuroprotective effects of rTMS are related to the mechanisms of protection against Aβ neurotoxicity.Organotypic hippocampal slices were prepared from 8-day old,Sprague Dawley rats.The tissue slices were exposed to 100 μmol/L Aβ1-42 since day 12 in vitro with and without high-frequency (20 Hz) magnetic stimulation.Magnetic stimulation efficacy was evaluated by measuring neuronal nuclei (NeuN) protein expression and by observing cultures following propidium iodide fluorescence staining and bromodeoxyuridine (BrdU) immunohistochemistry.Lactate dehydrogenase activity was detected in the culture media to evaluate hippocampal neuronal damage.Our results demonstrated that high-frequency magnetic stimulation significantly reversed the reduction of NeuN protein expression because of Aβ1-42 exposure (P < 0.05) and significantly reduced the number of damaged cells in the hippocampal slices (P < 0.05).However,lactate dehydrogenase levels and anti-BrdU staining results did not reveal any statistical differences.These findings indicate that high-frequency magnetic stimulation might have protective effect on hippocampal neurons from Aβ1-42 neurotoxicity.Don-Kyu Kim Young Chul Yoon Soo Ahn Chae Kyung Mook Seo Tai Ryoon Han Si-Hyun Kang 2010Neural Regeneration Research2010,5,18:2
2Movement of the hyoid bone and the epiglottis during swallowing in patients with dysphagia from different etiologies显示文摘Nam-Jong Paik Sang Jun Kim Ho Jun Lee Jae Yong Jeon Jae-Young Lim Tai Ryoon Han 2006Journal of Electromyography and Kinesiology2006,,2:1
3Quantifying swallowing function after stroke: A functional dysphagia scale based on videofluoroscopic studies显示文摘Tai Ryoon Han Nam-Jong Paik Jin Woo Park 2001Archives of Physical Medicine and Rehabilitation2001,,5:1
4Fecal calprotectin concentration in neonatal necrotizing enterocolitis显示文摘RYOON J M PARK J Y KO K O 2014Korean J Pedi-atr2014,57,8:1
5Quantifying swallowing function after stroke: A functional dysphagia scale based on videofluoroscopic studies 显示文摘Tai Ryoon Han Nam Jong Paik Jin Woo Park 2001Arch Phys Med Rehabil2001,,82:1
6Software certification of safety-critical avionic systems: DO-178C and its impacts 显示文摘Youn Won Keun Hong Seung Bum Oh Kyung Ryoon 2015Aerospace and Electronic Systems Magazine IEEE (S0885-8985)2015,30,4:1
7Effect of reverse curve of mushroom archwire on lower incisors in adult patients: A prospectivestudy 显示文摘Ryoon - ki H I-long HP Koh HS 2001AngleOrthod2001,71,:1
8Quantifying swallowing function after stroke: A functional dysphagia scale based on videofluoroscopic studies显示文摘Tai Ryoon Han Nam-Jong Paik Jin Woo Park 2001Archives of Physical Medicine and Rehabilitation2001,,5:1
9Quantifying swallowing function after stroke: A functional dysphagia scale based on videofluoroscopic studies显示文摘Tai Ryoon Han Nam-Jong Paik Jin Woo Park 2001Archives of Physical Medicine and Rehabilitation2001,,5:1
10Qusnfifying Swallowing Function After Strock:A Funtional Dysphagia Scale Based on Videofluoroscopic Studies显示文摘Tai Ryoon Han Nam-Jong Paik Jin Woo Park 2001Arck Phys Med Rehabil2001,82,:1
11Quantifying swallowing function after stroke: A functional dysphagia scale based on videofluoroscopic studies显示文摘Tai Ryoon Han Nam-Jong Paik Jin Woo Park 2001Archives of Physical Medicine and Rehabilitation2001,,5:1
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