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| 1 | Percutaneous transluminal angioplasty balloons for endoscopic ultrasound-guided pancreatic duct interventions显示文摘BACKGROUND Endoscopic ultrasound(EUS)-guided main pancreatic duct(PD)access may be used when conventional endoscopic retrograde cholangiopancreatography(ERCP)techniques fail.The use of a percutaneous transluminal angioplasty balloon(PTAB),originally developed for vascular interventions,can be used to facilitate transmural(e.g.,transgastric)PD access and to dilate high-grade pancreatic strictures.AIM To describe the technique,efficacy,and safety of PTABs for EUS-guided PD interventions.METHODS Patients who underwent EUS with use of a PTAB from March 2011 to August 2021 were retrospectively identified from a tertiary care medical center supply database.PTABs included 3-4 French angioplasty catheters with 3-4 mm balloons designed to use over a 0.018-inch guidewire.The primary outcome was technical success.Secondary outcomes included incidence of adverse events(AEs)and need for early reintervention.RESULTS A total of 23 patients were identified(48%female,mean age 55.8 years).Chronic pancreatitis was the underlying etiology in 13(56.5%)patients,surgically altered anatomy(SAA)with stricture in 7(30.4%),and SAA with post-operative leak in 3(13.0%).Technical success was achieved in 20(87%)cases.Overall AE rate was 26%(n=6).All AEs were mild and included 1 pancreatic duct leak,2 cases of post-procedure pancreatitis,and 3 admissions for post-procedural pain.No patients required early re-intervention.CONCLUSION EUS-guided use of PTABs for PD access and/or stricture management is feasible with an acceptable safety profile and can be considered in patients when conventional ERCP cannulation fails. | Jad P AbiMansour Barham K Abu Dayyeh Michael J Levy Andrew C Storm John A Martin Bret T Petersen Ryan J Law Mark D Topazian Vinay Chandrasekhara | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，8： | 2 |
| 2 | Implantation potential and fetal viability of mouse embryos cultured in media supplemented with platelet activating factor 显示文摘 | Ryan J P Spinks N R O'Neill C | 1990 | J Reprod Fertil1990，89，： | 2 |
| 3 | Hypoxia-inducible factor-1a restricts the anabolic actions of parathyroid hormone显示文摘The hypoxia inducible factors(Hifs) are evolutionarily conserved transcriptional factors that control homeostatic responses to low oxygen. In developing bone, Hif-1 generated signals induce angiogenesis necessary for osteoblast specification, but in mature bone, loss of Hif-1 in osteoblasts resulted in a more rapid accumulation of bone. These findings suggested that Hif-1 exerts distinct developmental functions and acts as a negative regulator of bone formation. To investigate the function of Hif-1a in osteoanabolic signaling, we assessed the effect of Hif-1a loss-of-function on bone formation in response to intermittent parathyroid hormone(PTH). Mice lacking Hif-1a in osteoblasts and osteocytes form more bone in response to PTH, likely through a larger increase in osteoblast activity and increased sensitivity to the hormone. Consistent with this effect, exposure of primary mouse osteoblasts to PTH resulted in the rapid induction of Hif-1a protein levels via a post-transcriptional mechanism. The enhanced anabolic response appears to result from the removal of Hif-1a-mediated suppression of b-catenin transcriptional activity. Together, these data indicate that Hif-1a functions in the mature skeleton to restrict osteoanabolic signaling. The availability of pharmacological agents that reduce Hif-1a function suggests the value in further exploration of this pathway to optimize the therapeutic benefits of PTH. | Julie L Frey David P Stonko Marie-Claude Faugere Ryan C Riddle | 2014 | Bone Research2014，2，1： | 2 |
| 4 | Evidence that decomposition rates of organic carbon in mineral soil do not vary with temperature显示文摘 | Ryan M G | 2000 | Nature2000，404，： | 1 |
| 5 | Characterization of pseudorabies virus glycoprotein C attachment to heparan sulfate proteoglycans显示文摘 | Rue C A Ryan P | 2002 | J Gen Virol2002，83，2： | 1 |
| 6 | Effects of Nb and Zr alloying additions on the activation behavior of Ti in hydrochloric acid显示文摘 | YU S Y BRODRICK C W RYAN M P | | 0，，12： | 1 |
| 7 | Trace elements in sulfide inclusions from Yakutian diamonds显示文摘 | Bulanova G P Griffin W L Ryan C G | 1996 | Contributions to Mineralogy and Petrology1996，124，2： | 1 |
| 8 | Pseudorabies virus glycoprotein C attachment-proficient revertants isolated hrough a simple,targeted mutagenesis scheme显示文摘 | Rue C A Ryan P | 2008 | J Virol Methods2008，151，1： | 1 |
| 9 | Pseudorabies virus glycoprotein C attachment proficient revertants isolated through a simple, targeted mutagenesis scheme显示文摘 | Rue C A Ryan P | 2008 | Journal of Virological Methods2008，151，1： | 1 |
| 10 | Formation of pyromorphite in an- glesite hydroxyapatite suspensions under varying pH condi- tions 显示文摘 | ZHANG P C RYAN J A | 1998 | Environ Sci Technol1998，32，21： | 1 |
| 11 | Temperature prediction in stratified reservoirs 显示文摘 | Huber W C Harleman D R F Ryan P J | 1972 | Journal of the Hydraulics Division1972，98，4： | 1 |
| 12 | Segregation of ore metals betweenmagmatic brine and vapor: a fluid inclusion study using PIXE microanalysis显示文摘 | HEINRICH C A RYAN C G MERNAGH T P | 1992 | EconomicGeology1992，87，： | 1 |
| 13 | A survey of wound-and methyl jasmonate-induced leaf polyphenol oxidase in crop plants显示文摘 | Constabel C P Ryan C A | 1998 | Phytochemistry1998，47，4： | 1 |
| 14 | Potentially inappropriate medications defined by STOPP criteria and the risk of adverse drug events in elder hospitalized patients显示文摘 | Hamilton H Gallagher P Ryan C | 2011 | Arch Intem Med2011，171，11： | 1 |
| 15 | Cbl and human myeloid neoplasms:the Cbl oncogeoe comes of age显示文摘 | Kales S C Ryan P E Nau M M Lipkowitz S | | 0，，12： | 1 |
| 16 | Stability of the total antioxidant capacity and total polyphenol content of 23 commercially available vegetable juices before and after in vitro digestion measured by FRAP,DPPH,ABTS and FolinCiocalteu methods显示文摘 | Wootton B P C Moran A Ryan L | | 0，，01： | 1 |
| 17 | The effects of acute and chronic JJ stent placement on upper uri- nary tract motility and calculus placement显示文摘 | Ryan P C Lennon G M Fitzpatrick J M | 1994 | Br J Urol1994，74，4： | 1 |
| 18 | The effects of acute and chronic JJ stent placement on upper urinary tract motility and calculus transit显示文摘 | RYAN P C LENNON G M MCLEAN P A | 1994 | Urology1994，74，： | 1 |
| 19 | Barley 13-glucan extracts as rich sources o显示文摘 | Thondre P S Ryan L Henry C J K | 2011 | Food Chemis- try2011，126，1： | 1 |
| 20 | fMRI of neuronal activation with symptom provocation in unmedicated patients with obsdessive - compulsive disorder 显示文摘 | ADLER C M MCDONOUGH RYAN P SAX K W | 2000 | J Psychiatr Res2000，34，4： | 1 |
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